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THE EXPRESS ROUTE TO USMLE EXCELLENCE IN GENETICS
High-Yield * Illustrated * USMLE Shortcuts
You'll never find an easier, more efficient, and more focused way to ace genetics and genetics-related questions on the USMLE and course examinations than the USMLE Road Map. Designed to provide maximum learning in minimum time, this fully updated USMLE Road Map offers a concise, creative, and well-illustrated approach to mastering genetics.
The right way--the right questions--the right results
Using the Road Map Series for Successful Review ix
Preface xi
1 Principles 1
I Proteins 1
II Nucleic Acids 1
III Tools of Molecular Genetics 7
IV Variations 11
V Pedigree Analysis 14
VI Genetic Testing 15
Clinical Problems 21
Answers 22
2 Chromosomes and Chromosomal Disorders 23
I Chromosome Biology 23
II Chromosome Analysis 23
III Mitosis 25
IV Meiosis 27
V Linkage 31
VI Chromosomal Disorders 33
Clinical Problems 43
Answers 44
3 Autosomal Dominant Inheritance 46
I General Principles 46
II Recurrence Risks 50
Clinical Problems 50
Answers 51
4 Autosomal Recessive Inheritance 53
I General Principles 53
II Implications of the Carrier State 59
Clinical Problems 59
Answers 60
5 X-Linked Inheritance 62
I General Principles 62
II The Female Carrier 64
III X-Linked Dominant Inheritance 65
Clinical Problems 66
Answers 67
6 Mitochondrial Dysfunction 68
I General Principles 68
II Mitochondrial Physiology 68
Clinical Problems 70
Answers 71
7 Congenital Changes 73
I Spectrum of Changes 73
II Approach 73
Clinical Problems 78
Answers 79
8 Genetics and Immune Function 80
I Self versus Nonself 80
II Major Histocompatibility Complex (MHC) 80
III HLA-Disease Associations 83
IV Immunoglobulins 84
V T-Cell Receptors 86
VI Ig Gene Superfamily 86
VII Features of Inherited Changes in Immune Function 87
Clinical Problems 87
Answers 90
9 Genetics and Cancer 91
I Gene Changes 91
II Chromosome Changes 91
III Gatekeeper Genes 94
IV Caretaker Genes 95
V Gene Analysis in Cancer 95
Clinical Problems 96
Answers 97
10 Genetics and Common Diseases 99
I Genetic Variations Underlying Disease99
II Epidemiologic Findings 99
III Threshold Model of Disease 101
IV Implications for Screening and Patient Care 103
Clinical Problems 106
Answers 107
11 Pharmacogenetics 109
I Overview 109
II Current Limitations and Recent Advances 109
III Treatment-related Issues 109
Clinical Problems 111
Answers 112
12 Genetics and Medical Practice 113
I Diagnosis 113
II Resources for Genetic Information 113
III Genetic Screening 116
IV Treatment 117
V Prognosis 123
VI Issues in Treatment of Genetic Diseases 123
Clinical Problems 124
Answers 125
Appendix: Indications for Genetic Consultation Referral 127
Index 135
Overview
THE EXPRESS ROUTE TO USMLE EXCELLENCE IN GENETICS
High-Yield * Illustrated * USMLE Shortcuts
You'll never find an easier, more efficient, and more focused way to ace genetics and genetics-related questions on the USMLE and course examinations than the USMLE Road Map. Designed to provide maximum learning in minimum time, this fully updated ...