Genetics in Endocrinology

Overview

An extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the Modern Endocrinology Series, this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine ...

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Overview

An extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the Modern Endocrinology Series, this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine diseases.

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Editorial Reviews

From The Critics
This text is one in a three-volume set devoted to major pathophysiological mechanisms underlying many known endocrine diseases: hormone hyperresponsiveness/hyporesponsiveness, gene mutations, and autoimmunity. Seventy-eight international specialists contribute 33 chapters on genetics as it applies to endocrinology in general and the diagnosis and treatment of disorders of the endocrine system. Background information on genetics in endocrinology is followed by chapters on the classical diseases facing endocrinologists, and more recent diseases of importance, such as obesity, those causing abnormalities in lipoproteins, and those of the skeletal system. Other topics include the role of hormones in cancer, insulin-dependent diabetes, autoimmune thyroid disease, and resistance syndromes. For the clinician, researcher, and student of endocrinology. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780781714969
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 4/28/2002
  • Series: Modern Endocrinology Series
  • Pages: 784

Table of Contents

Contributing Authors
Series Preface
Preface
1 Principles of Endocrine Genetics 1
2 Transgenic Animal Models of Pituitary Function 27
3 Genetics of Type I Diabetes Mellitus 37
4 Ectopic Pituitary Hormone Production 73
5 Molecular Genetics of Human Growth Disorders Related to the Growth Hormone-Insulin-Like Growth Factor-I 87
6 Molecular Pathogenesis of Pituitary Failure 107
7 Sexual Differentiation 117
8 The Genetics of the Autoimmune Thyroid Diseases 137
9 Disorders Affecting Parathyroid Hormone 153
10 Familial Endocrine Cancer, MEN-I and MEN-II 167
11 Laboratory Evaluation and Screening of Genetic Endocrine Disease 189
12 G-Protein Abnormalities in Endocrine Diseases 221
13 Type 2 Diabetes Mellitus 237
14 Polycystic Ovary Syndrome: Candidate Genes for Hyperandrogenism and Hyperinsulinemia 267
15 The Genetics of Obesity 275
16 Pituitary Tumor Pathogenesis 305
17 Diabetes Insipidus 313
18 Genetics of Adrenal Steroid Disorders 331
19 Genetics of Sex Determination 365
20 Genetic Disorders of the Thyroid Hormone System 375
21 Disorders Affecting the [beta]-Subunits of Pituitary Glycoprotein Hormones 403
22 Genetic Disorders of Parathyroid Hormone Action 423
23 The Vitamin D Endocrine System: Metabolism, Mode of Action, and Genetic Evaluation 445
24 Genetic Disorders of Skeletal Mineral Metabolism 473
25 Principles of Gene Therapy 491
26 Knockout and Transgenic Mouse Models of Endocrine Disorders 521
27 Genetic Disorders of Lipid Transport 537
28 Pituitary Hormone Gene Regulation 565
29 Hypothalamic Releasing Hormone Receptors: Structure and Function 585
30 Endocrine-Sensitive Cancers of the Prostate and Breast 607
31 Resistance to Glucocorticoid and Mineralocorticoid Hormones 663
32 Androgen Resistance and Disorders of Androgenic Metabolism 709
33 The Impact of Sequencing of the Human Genome on Endocrinology 739
Subject Index 747
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