Genetics: From Genes to Genomes / Edition 3

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Overview

The authors have developed a text that reflects the directions Genetics is taking as it heads into the 21st century. This perspective embraces five major themes: 1. the central importance of the genome,as opposed to the action of individual genes; 2. the application of genetics to the improvement of human health; 3. the growing appreciation for the relationships among organisms arising from genetic research; 4. the impact of biotechnology on the accelerating growth of genetic knowledge; and 5. the importance of emerging social and ethical issues related to our use of biotechnology.
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Product Details

  • ISBN-13: 9780072848465
  • Publisher: McGraw-Hill Companies, The
  • Publication date: 8/28/2006
  • Edition description: Third Edition
  • Edition number: 3
  • Pages: 960

Meet the Author

Dr. Hartwell received his Ph.D from MIT. He has held Assistant and Associate Professorships at the University of California before joining the faculty of the University of Washington, where he continues as a Full Professor. In 1996, Dr. Hartwell joined the Fred Hutchinson Cancer Research Center as a Full Member and Senior Advisor for Scientific Affairs, and was named President and Director of the Center in July, 1997.

Dr. Hartwell has received numerous awards and honors in the course of his career. Among them he received the Brandeis university Rosenteil Award in 1993, and the sloan-kettering Cancer Center Katherine Berkan Judd Award as well as the Genetics Society of America Medal in 1994. In 1995 he was awarded the MGH Warren Triennial Price and in 1996 was awarded the Columbia University Horwitz Award and the Passano Award. Dr. Hartwell received the Albert Lasker Award for medical research in 1998.

Dr. Hood received an MD from the Johns Hopkins Medical Schooland a PhD in Biochemistry from the California Institute of Technology. His research interests include immunology, development and the development of biological instrumentation (e.g. the protein sequenator and the automated fluorescent DNA sequencer). His research played a key role in unraveling the mysteries of anitbody diversity. Dr. Hood has taught molecular evolution, immunology, molecular biology and biochemistry. he is currently the Chairman (and founder) of the cross-disciplinary Department of Molecular Biotechnology at the University of Washington. Dr. Hood has received a variety of awards including the Albert Lasker Award for Medical Research (1987), Dickson Price (1987), Cefas Award for Biochemistry (1989), and the Distinguished Service Award from the national Association of Teachers (1998). He is deeply involved in K-12 science educatiohn. His hobbies include running, mountain climbing, and reading.

Dr. Goldberg is a professor at Cornell University where he teaches introductory Genetics. He was an undergraduate at Yale University, and received his PhD in Biochemistry from Stanford University. Dr. Goldberg performed postdoctoral research at the Biozentrum of the University of Basel (Switzerland), posdoctoral research at the Biozentrum of the University of Basel and at Harvard University, and received an NIH Fogarty Senior International Fellowship for study at Imperial College (England) and at the University fo Rome (Italy). His current research utilizes the tools of Drosophila genetics to investigate the mechansims that ensure proper chromosome segregation during mitosis and meiosis.

Dr. Reynolds is an educator and author who has been teaching genetics and biology since 1990. An affiliate faculty member of the Genetics Department at the University of Washington, her research has included studies of gene regulation in E. coli, chromosome structure and DNA replication in yeast, and chloroplast gene expression in marien algae. She is a graduate of Mount Holyoke College and received her PhD from Tufts University. Dr. Reynolds was a post doctoral research fellow witht he Harvard University Department of Molecular Biology. Dr. Reynolds was also an author and producer of the laserdisc and CD-ROM Genetics: Fundamentals to Frontiers.

Dr. Silver is a Professor at Princeton University in the Departments of Molecualr Biology, Ecology and Evolutionary Biology, and the program in Neuroscience. Dr. silver graduated from the University of Pennsylvania with BA and MS degrees in physics, and from Harvard University with a PhD in biophysics. He was a research fellow at the Sloan-Kettering Institute for Cancer Research and a seniro scientist at Cold Harbor Lab before coming to Princeton. He is the author of "Remaking Eden: Cloning and Beyond in a Brave New World." He is also the co-editor-in-chief of a new international journal entitled "Clining: Science and Policy," and co-editor-in-chief of "Mammalian Genome," the official journal of the International Mammalian Genome society. In 1993, Dr. Silver was elected a Fellow fo the AAAS.

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Table of Contents

1 Genetics: The Study of Biological Information

2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity

3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype

4 The Chromosome Theory of Inheritance

5 Linkage, Recombination, and the Mapping of Genes on Chromosomes

6 DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information

7 Anatomy and Function of a Gene: Dissection Through Mutation

8 Gene Expression: The Flow of Genetic Information from DNA to RNA to Protein

9 Deconstructing the Genome: DNA at High Resolution

10 Reconstructing the Genome Through Genetic and Molecular Analysis

11 The Direct Detection of Genotype Distinguishes Individual Genomes

12 Systems Biology and Proteomics

13 The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA

14 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes

15 The Prokaryotic Chromosome: Genetic Analysis in Bacteria

16 The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of Inheritance

17 Gene Regulation in Prokaryotes

18 Gene Regulation in Eukaryotes

19 Cell-Cycle Regulation and the Genetics of Cancer

20 Using Genetics to Study Development

21 The Genetic Analysis of Populations and How They Evolve

22 Evolution at the Molecular Level
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