Genetics: From Genes to Genomes / Edition 4

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Overview

The authors have developed a text that reflects the directions Genetics is taking as it heads into the 21st century. This perspective embraces five major themes: 1. the central importance of the genome,as opposed to the action of individual genes; 2. the application of genetics to the improvement of human health; 3. the growing appreciation for the relationships among organisms arising from genetic research; 4. the impact of biotechnology on the accelerating growth of genetic knowledge; and 5. the importance of emerging social and ethical issues related to our use of biotechnology.
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Product Details

  • ISBN-13: 9780073525266
  • Publisher: McGraw-Hill Higher Education
  • Publication date: 9/14/2010
  • Edition description: New Edition
  • Edition number: 4
  • Pages: 816
  • Sales rank: 70,075
  • Product dimensions: 8.70 (w) x 11.00 (h) x 1.30 (d)

Meet the Author

Dr. Leland Hartwell is President and Director of Seattle’s Fred Hutchinson Cancer

Research Center and Professor of Genome Sciences at the University of Washington.

Dr. Hartwell’s primary research contributions were in identifying genes that control

cell division in yeast, including those necessary for the division process as well as

those necessary for the fi delity of genome reproduction. Subsequently, many of these

same genes have been found to control cell division in humans and oft en to be the

site of alteration in cancer cells.

Dr. Hartwell is a member of the National Academy of Sciences and has received

the Albert Lasker Basic Medical Research Award, the Gairdner Foundation

International Award, the Genetics Society Medal, and the 2001 Nobel Prize in

Physiology or Medicine.

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Table of Contents

1 Genetics: The Study of Biological Information

2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity

3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype

4 The Chromosome Theory of Inheritance

5 Linkage, Recombination, and the Mapping of Genes on Chromosomes

6 DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information

7 Anatomy and Function of a Gene: Dissection Through Mutation

8 Gene Expression: The Flow of Genetic Information from DNA to RNA to Protein

9 Deconstructing the Genome: DNA at High Resolution

10 Reconstructing the Genome Through Genetic and Molecular Analysis

11 The Direct Detection of Genotype Distinguishes Individual Genomes

12 Systems Biology and Proteomics

13 The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA

14 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes

15 The Prokaryotic Chromosome: Genetic Analysis in Bacteria

16 The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of Inheritance

17 Gene Regulation in Prokaryotes

18 Gene Regulation in Eukaryotes

19 Cell-Cycle Regulation and the Genetics of Cancer

20 Using Genetics to Study Development

21 The Genetic Analysis of Populations and How They Evolve

22 Evolution at the Molecular Level
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