Genetics: From Genes to Genomes / Edition 2

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The authors have developed a text that reflects the directions Genetics is taking as it heads into the 21st century. This perspective embraces five major themes: 1. the central importance of the genome,as opposed to the action of individual genes; 2. the application of genetics to the improvement of human health; 3. the growing appreciation for the relationships among organisms arising from genetic research; 4. the impact of biotechnology on the accelerating growth of genetic knowledge; and 5. the importance of emerging social and ethical issues related to our use of biotechnology.
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Product Details

  • ISBN-13: 9780072462487
  • Publisher: McGraw-Hill Companies, The
  • Publication date: 3/4/2003
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 944
  • Product dimensions: 8.60 (w) x 11.10 (h) x 1.30 (d)

Meet the Author

Dr. Leland Hartwell is President and Director of Seattle’s Fred Hutchinson Cancer

Research Center and Professor of Genome Sciences at the University of Washington.

Dr. Hartwell’s primary research contributions were in identifying genes that control

cell division in yeast, including those necessary for the division process as well as

those necessary for the fi delity of genome reproduction. Subsequently, many of these

same genes have been found to control cell division in humans and oft en to be the

site of alteration in cancer cells.

Dr. Hartwell is a member of the National Academy of Sciences and has received

the Albert Lasker Basic Medical Research Award, the Gairdner Foundation

International Award, the Genetics Society Medal, and the 2001 Nobel Prize in

Physiology or Medicine.

Dr. Michael Goldberg is a professor at Cornell University, where he teaches introductory

genetics and human genetics. He was an undergraduate at Yale University

and received his Ph.D. in biochemistry from Stanford University. Dr. Goldberg performed

postdoctoral research at the Biozentrum of the University of Basel (Switzerland)

and at Harvard University, and he received an NIH Fogarty Senior International

Fellowship for study at Imperial College (England) and fellowships from the

Fondazione Cenci Bolognetti for sabbatical work at the University of Rome (Italy).

His current research uses the tools of Drosophila genetics and the biochemical analysis

of frog egg cell extracts to investigate the mechanisms that ensure proper cell

cycle progression and chromosome segregation during mitosis and meiosis.

Dr. Janice Fischer is a Professor at The University of Texas at Austin, where she is

an award-winning teacher of genetics and Director of the Biology Instructional Office.

She received her Ph.D. in biochemistry and molecular biology from Harvard

University, and did postdoctoral research at The University of California at Berkeley

and The Whitehead Institute at MIT. In her current research, Dr. Fischer uses

Drosophila to examine the roles of ubiquitin and endocytosis in cell signaling during


Dr. Hood received an MD from the Johns Hopkins Medical Schooland a PhD in Biochemistry from the California Institute of Technology. His research interests include immunology, development and the development of biological instrumentation (e.g. the protein sequenator and the automated fluorescent DNA sequencer). His research played a key role in unraveling the mysteries of anitbody diversity. Dr. Hood has taught molecular evolution, immunology, molecular biology and biochemistry. he is currently the Chairman (and founder) of the cross-disciplinary Department of Molecular Biotechnology at the University of Washington. Dr. Hood has received a variety of awards including the Albert Lasker Award for Medical Research (1987), Dickson Price (1987), Cefas Award for Biochemistry (1989), and the Distinguished Service Award from the national Association of Teachers (1998). He is deeply involved in K-12 science educatiohn. His hobbies include running, mountain climbing, and reading.

Dr. Charles Aquadro (Chip) is Professor of Population Genetics, the Charles A.

Alexander Professor of Biological Sciences, and Director of the Center for

Comparative and Population Genomics at Cornell University. He obtained his

Ph.D. in genetics from the University of Georgia, was a postdoc at the National

Institute for Environmental Health Sciences/NIH, and joined the faculty at Cornell

University in 1985 where he is now a professor. He has served as President of the

Society of Molecular Biology and Evolution, is an elected Fellow of the AAAS, is a

member of the Scientific Advisory Board for National Geographic Society’s

Genographic Project, was a member of the Scientific Advisory Board for the

WGBH/NOVA TV series “Evolution,” and has been a visiting scholar at Cambridge

University (England, 1993) and Harvard University (2007). His research and teaching

focuses on molecular population genetics, molecular evolution, and comparative

genomics. While Drosophila is his primary research system, recent work has also

involved yeast, humans, and plants. At Cornell, he teaches a university-wide course

to nonmajors on personal genomics and medicine, and a major’s course in population


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Table of Contents

1. Genetics: The Study of Biological Information
2. Mendel’s Principles of Heredity
3. Extensions to Mendel’s Laws
4. The Chromosome Theory of Inheritance
5. Linkage, Recombination, and the Mapping of Genes on Chromosomes
6. DNA Structure, Replication, and Recombination
7. Anatomy and Function of a Gene: Dissection Through Mutation
8. Gene Expression: The Flow of Information from DNA to RNA to Protein
9. Digital Analysis of Genomes
10. Analyzing Genomic Variation
11. The Eukaryotic Chromosome
12. Chromosomal Rearrangements and Changes in Chromosome Number
13. Bacterial Genetics
14. Organellar Inheritance
15. Gene Regulation in Prokaryotes
16. Gene Regulation in Eukaryotes
17. Manipulating the Genomes of Eukaryotes
18. The Genetic Analysis of Development
19. The Genetics of Cancer
20. Variation and Selection in Populations
21. Genetics of Complex Traits
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