Genetics of Common Diseases: Future Therapeutic and Diagnostic Possibilities / Edition 1

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Overview

Genetics of Common Diseases : Future Therapeutic and Diagnostic Possibilities is a unique collection of articles by leading authorities in disease genetics research. It presents the principles of analysis of genetic diseases and a range of potential approaches to their management, ranging from conventional drugs to gene therapy, which might utilize the knowledge of genotype-specific risks. The value to the general population of the ability to diagnose and predict the risk of various diseases is assessed.
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Product Details

  • ISBN-13: 9781859960417
  • Publisher: Taylor & Francis
  • Publication date: 6/15/1997
  • Series: Ucl Molecular Pathology Series
  • Edition number: 1
  • Pages: 344
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.88 (d)

Table of Contents

Contributors
Abbreviations
Preface
1 Perspectives in human linkage studies 1
2 Twin research: nature versus nurture in common diseases 19
3 The molecular basis of genetic variation: mutation detection methodologies and limitations 33
4 Finding susceptibility genes for schizophrenia 75
5 Approaches to determining the genetic basis of non-insulin-dependent diabetes mellitus 91
6 Population-scale genotype assays: APOE gene in Alzheimer's dementia and coronary risk 129
7 Genetic tests for coronary artery disease risk: the fibrinogen and stromelysin genes as examples 151
8 HLA genes and rheumatoid arthritis susceptibility 171
9 Practical benefits from understanding the genetics of chronic diseases 185
10 Specific approaches to pulmonary emphysema and its therapy 203
11 Gene therapy for neurological diseases: quo vadis? Achievements and expectations of, and challenges for, the brave new technology 219
12 Impact of genomics on the discovery and development of modern medicines 241
13 Oligonucleotides and their future potential as therapeutic agents 263
14 Protein engineering of therapeutic antibodies: use of antibodies for immunosuppression and treatment of leukaemias 285
15 Getting to know your genes privately 307
Index 323
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