Genetics of Mental Disorders: What Practitioners and Students Need to Know by Stephen V. Faraone, Ming T. Tsuang, Debby W. Tsuang |, Paperback | Barnes & Noble
Genetics of Mental Disorders: What Practitioners and Students Need to Know

Genetics of Mental Disorders: What Practitioners and Students Need to Know

by Stephen V. Faraone, Ming T. Tsuang, Debby W. Tsuang
     
 

This book provides a comprehensive and readable primer on the complex interplay of genetic and environmental factors in mental disorders. Re ndering technical concepts accessible, and laying to rest common myths and oversimplifications, the book describes what (and how) scientists have learned about the causation and expression of such frequently en countered

Overview

This book provides a comprehensive and readable primer on the complex interplay of genetic and environmental factors in mental disorders. Re ndering technical concepts accessible, and laying to rest common myths and oversimplifications, the book describes what (and how) scientists have learned about the causation and expression of such frequently en countered disorders as schizophrenia, bipolar disorder, depression, an d Alzheimer disease. Clinicians and students gain the basic knowledge they need to evaluate the literature in this rapidly developing field, understand implications for treatment, and communicate genetic inform ation to clients and families. Throughout, special attention is given to the critical ethical and professional concerns raised by emerging t echnologies.

Editorial Reviews

From the Publisher
"Genetics of Mental Disorders, a primer on psychiatric genetics whose authors have long experience in genetic research and teaching, is a strong candidate for becoming a basic text for those embarking on careers in research, teaching, or clinical practice. With its admirable blend of fundamental facts and clinical applications, the book will be helpful to professionals in various disciplines. Particularly useful are the highlighted summary statements labeled 'key points' and the nuggets called 'clinical tips.' These help the reader fixate the more detailed and complex material from preceding sections."—Psychiatric Services

"This volume offers an important introductory resource for those interested in understanding genetic influences on mental disorders. Although geared primarily toward practicing clinicians, the book lives up to its title in that it covers topics that would also be of interest to residents and students in the fields of psychiatry, molecular genetics, psychiatric genetics, and genetic epidemiology, as well as to other social science researchers who want to learn the basics of psychiatric genetics. The clarity with which the authors deal with complicated issues and scientific terminology also indicates that it might be of use to the advanced layman or upper-level undergraduate with interests in understanding the role that genetics plays in mental illness....the book is well written....the authors make a conscientious effort to define the terminologies and often use examples to help clarify the concepts. The book contains over 50 figures and 19 tables, which also aid the reader in understanding sometimes difficult concepts. The book is also well organized....offers a comprehensive look at the present and future of psychiatric genetics that is of use to researchers, students, and clinicians alike."—The Journal of Nervous and Mental Disease

"...an easily read primer, leading the reader from very basic principles through a catalog of modern genetics theory and technique, using frequent clinical examples....the role of environmental influences is consistently pointed out. Perhaps most importantly, this is done with a free-flowing, enthusiastic style that is a pleasure to read....Readers who would benefits from this book include practitioners interested in understanding the genetics literature and those beginning in research. It would make an excellent supplement to the genetics component of psychiatry residency didactics. A substantial glossary aids the nonmedical reader....The authors have succeeded in creating a paradox; an easily read book that explains modern psychiatric genetics in less than 300 pages."—Archives of Neurology

"Students, clinicians and researchers who study the genetic roots of mental disease will find this an involving overview which provides a comprehensive introduction to psychiatric genetics....can be absorbed by lay readers."—The Midwest Bookwatch

"This book is a concise and original summary of methods and guidelines in the field of psychiatric genetics. It will be useful to many individuals without previous genetic training: undergraduate and graduate students, psychologists, social workers, psychiatric residents, and practicing psychiatrists."—Psychiatric Times

"This primer on psychiatric genetic methodology will be a valued reference for those who remain mystified by quantitative and molecular genetics. The text is ideally suited for upper-level undergraduates, clinical psychology graduate students, psychiatric residents, mental health practitioners, and scientists with limited expertise in behavioral genetics."—William G. Iacono, PhD, Distinguished McKnight University Professor Director, Clinical Science and Psychopathology Research Training Program, Department of Psychology, University of Minnesota

"Genetics of Mental Disorders is exquisitely written for psychiatrists-in-training or those who are unfamiliar with genetic principles and their applications to research and patient care. This text will begin to prepare clinicians for the employment of genetic understandings and new technologies with their patients. This lucid and precise summary succeeds in making a complex topic accessible. It is a pleasure to read and should be on the bookshelf of every psychiatrist-in-training."—Barbara Biesecker, MS, Genetic Counselor, Co-Director of the Section of Genetic Counseling Research and Training, National Human Genome Research Institute, National Institute of Health

Psychiatric Services
"[This book] is a strong candidate for becoming a basic text for those embarking on careers in research, teaching, or clinical practice. With its admirable blend of fundamental facts and clinical applications, the book will be helpful to professionals in various disciplines."—Psychiatric Services
Journal of Nervous and Mental Disease
"An important introductory resource....The authors make a conscientious effort to define the terminologies and often use examples to help clarify the concepts. The book contains over 50 figures and 19 tables, which also aid the reader in understanding sometimes difficult concepts. The book is also well organized....Offers a comprehensive look at the present and future of psychiatric genetics."—Journal of Nervous and Mental Disease
Archives of Neurology
"An easily read primer, leading the reader from very basic principles through a catalog of modern genetics theory and technique, using frequent clinical examples....The role of environmental influences is consistently pointed out. Perhaps most importantly, this is done with a free-flowing, enthusiastic style that is a pleasure to read....The authors have succeeded in creating a paradox; an easily read book that explains modern psychiatric genetics in less than 300 pages."—Archives of Neurology
Psychiatric Times
"Concise and original....Will be useful to many individuals without previous genetic training: undergraduate and graduate students, psychologists, social workers, psychiatric residents, and practicing psychiatrists."—Psychiatric Times
William Scheftner
This book is an attempt to introduce the investigative methods of human genetics as applied to mental disorders, their clinical applications, and some of the biological, ethical, and legal implications of the investigative processes and conclusions. The purpose is to offer "...the facts you will need to make informed clinical and ethical decisions when information about genetic risk will be available ... show you the tools of psychiatric genetics ... (and) address some misconceptions about the profession." These objectives are worthy. Since the authors have concentrated on conceptual issues and generally avoided technical (mathematical and biochemical) ones, this book fills a clear need in the literature. I believe they have succeeded in providing a solid conceptual introduction to all of those facts and topics as they now exist. The book is written for beginners in psychiatric genetics who have a rudimentary knowledge of genetics regardless of discipline or clinical expertise. It is targeted solely at the mental health professions — psychiatrists and other clinicians. The authors and editors are internationally renowned experts in psychiatric genetics. The book is logically organized with a discussion of the aims and content of genetic epidemiology, the progression of clinical work from family history studies, case controlled studies to epidemiologic studies, and what each can contribute to understanding the transmission of mental disorders. There is also discussion of clinical and causal heterogeneity followed by a major section on the various modes of genetic transmission and how those modes are determined mathematically. A brief outline of DNA transmission of genesfollowed by the concept of DNA markers and the various statistical analyses of the relationship between those markers and the presence of a psychiatric disorder is included. The connection between a specific gene(s) and the disorder is discussed. Thereafter, the focus shifts to practical clinical aspects of genetic counseling, the broader uses of genetic diagnoses, and the ethical safeguards needed. The chapters on epidemiologic foundations of psychiatric genetics and clinical and causal heterogeneity are extraordinarily well done and should be a part of every psychiatric resident's curriculum. There are no real shortcomings of this book. Given the difficulty of the topic, more space and illustrations might have been devoted to the sections on mathematical models of inheritance and molecular genetics, since the book is a summary introduction to the field. The authors have produced a first-rate introduction to the subject of genetic investigation of psychiatric disorders. Because of the complexity of the field, material is presented on epidemiology, genetics, molecular genetics, and clinical implications in one volume. This provides a level of familiarity for the reader who wants to pursue advanced texts as well as for the reader who wishes to read general psychiatric journals with reasonable but not perfect comprehension. I am unaware of any book which would permit comparison.
Reviewer: William Scheftner, MD (Rush-Presbyterian-St. Luke's Medical Center)
Description: This book is an attempt to introduce the investigative methods of human genetics as applied to mental disorders, their clinical applications, and some of the biological, ethical, and legal implications of the investigative processes and conclusions.
Purpose: The purpose is to offer "...the facts you will need to make informed clinical and ethical decisions when information about genetic risk will be available ... show you the tools of psychiatric genetics ... (and) address some misconceptions about the profession." These objectives are worthy. Since the authors have concentrated on conceptual issues and generally avoided technical (mathematical and biochemical) ones, this book fills a clear need in the literature. I believe they have succeeded in providing a solid conceptual introduction to all of those facts and topics as they now exist.
Audience: The book is written for beginners in psychiatric genetics who have a rudimentary knowledge of genetics regardless of discipline or clinical expertise. It is targeted solely at the mental health professions:psychiatrists and other clinicians. The authors and editors are internationally renowned experts in psychiatric genetics.
Features: The book is logically organized with a discussion of the aims and content of genetic epidemiology, the progression of clinical work from family history studies, case controlled studies to epidemiologic studies, and what each can contribute to understanding the transmission of mental disorders. There is also discussion of clinical and causalheterogeneity followed by a major section on the various modes of genetic transmission and how those modes are determined mathematically. A brief outline of DNA transmission of genes followed by the concept of DNA markers and the various statistical analyses of the relationship between those markers and the presence of a psychiatric disorder is included. The connection between a specific gene (s) and the disorder is discussed. Thereafter, the focus shifts to practical clinical aspects of genetic counseling, the broader uses of genetic diagnoses, and the ethical safeguards needed. The chapters on epidemiologic foundations of psychiatric genetics and clinical and causal heterogeneity are extraordinarily well done and should be a part of every psychiatric resident's curriculum. There are no real shortcomings of this book. Given the difficulty of the topic, more space and illustrations might have been devoted to the sections on mathematical models of inheritance and molecular genetics, since the book is a summary introduction to the field.
Assessment: The authors have produced a first-rate introduction to the subject of genetic investigation of psychiatric disorders. Because of the complexity of the field, material is presented on epidemiology, genetics, molecular genetics, and clinical implications in one volume. This provides a level of familiarity for the reader who wants to pursue advanced texts as well as for the reader who wishes to read general psychiatric journals with reasonable but not perfect comprehension. I am unaware of any book which would permit comparison.
Booknews
A readable introduction to the science and practice of psychiatric genetics, covering the interplay of genes and environmental factors involved in the causation and expression of frequently encountered disorders including schizophrenia and Alzheimer's disease. Reviews principles of psychiatric genetics and shows how to understand and conduct family, twin, adoption, and other studies. The role of the genetic counselor is described in detail, and approaches to incorporating genetic data in diagnosis and treatment of the mentally ill are also discussed. Gives special attention to ethical and professional concerns raised by new and emerging technologies. The authors are MDs and professors associated with Harvard Medical School and the University of Washington. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Internet Bookwatch
Students, clinicians and researchers who study the genetic roots of mental disease will find this an involving overview which provides a comprehensive introduction to psychiatric genetics. From the contributions of genes and environment to mental health to genetic predispositions and transmission links, Genetics of Mental Disorders offers chapters which sound detailed and involved, but which can be absorbed by lay readers.

Product Details

ISBN-13:
9781572307391
Publisher:
Guilford Publications, Inc.
Publication date:
12/28/2001
Edition description:
New Edition
Pages:
272
Product dimensions:
6.00(w) x 9.00(h) x (d)

What People are saying about this

William G. Iacono
... The text is ideally suited for upper level undergraduates, clinical psychology graduate students, psychiatric residents, mental health practitioners, and scientists with limited expertise in behavioral genetics.
— William G. Iacono, Ph.D., Distinguished McKnight University Professor and Director, Clinical Science and Psychopathology Research Training Program, Department of Psychology, University of Minnesota

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