Genetics of Mental Retardation [NOOK Book]

Overview

Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and ...

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Genetics of Mental Retardation

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Overview

Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential to neurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of both the environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.

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Meet the Author

University of California, Irvine (Emeritus)
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Table of Contents

1 Science, society, and mental retardation : a history 3
2 Neurogenesis, neuronal migration, maturation, and function : insights into learning and memory 26
3 Structural brain anomalies and neural tube defects 57
4 Mental retardation associated with dysmorphology, growth retardation, or overgrowth 75
5 Mental retardation associated with other neurological defects 112
6 Mental retardation that develops after a period of normal cognition 145
7 Nonsyndromic mental retardation, autism, and language deficits 181
8 Genomics, functional genomics, and epigenetics : relevance to mental retardation 198
9 Establishing a diagnosis and determining etiology in developmental delay and mental retardation 220
10 Epilogue : the value of genetic diagnosis - applying knowledge about etiology at prevention and treatment 231
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Sort by: Showing 1 Customer Reviews
  • Anonymous

    Posted November 11, 2012

    Duh

    Nyurp-e-durp!!

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