Genetics of Obesity Syndromes

Genetics of Obesity Syndromes

by Philip R. Beales
     
 

Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of

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Overview

Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients.
The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.

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Product Details

ISBN-13:
9780195300161
Publisher:
Oxford University Press, USA
Publication date:
08/29/2008
Series:
Oxford Monographs on Medical Genetics Series
Pages:
304
Product dimensions:
6.40(w) x 9.30(h) x 1.00(d)

Table of Contents

Pt. I Introduction

1 Introduction Philip L. Beales Beales, Philip L. I. Sadaf Farooqi Farooqi, I. Sadaf 3

2 A Practical Guide to the Clinical Assessment and Investigation of Obesity I. Sadaf Farooqi Farooqi, I. Sadaf 25

Pt. II Nonsyndromic Obesity

3 Human Leptin and Leptin Receptor Deficiency I. Sadaf Farooqi Farooqi, I. Sadaf Stephen O'Rahilly O'Rahilly, Stephen 37

4 Pro-opiomelanocortin Deficiency Heiko Krude Krude, Heiko Annette Gruters Gruters, Annette 49

5 Prohormone Convertase 1 Robert S. Jackson Jackson, Robert S. 63

6 Human Melanocortin 4 Receptor Deficiency I. Sadaf Farooqi Farooqi, I. Sadaf Stephen O'Rahilly O'Rahilly, Stephen 81

Pt. III Syndromlc Obesity

7 Albright Hereditary Osteodystrophy, Pseudohypoparathyroidism, and Other GNAS-Associated Syndromes Louise C. Wilson Wilson, Louise C. 91

8 The Clinical and Molecular Genetics of Alstrom Syndrome Gayle B. Collin Collin, Gayle B. Jan D. Marshall Marshall, Jan D. Jurgen K. Naggert Naggert, Jurgen K. Patsy M. Nishina Nishina, Patsy M. 133

9 The Clinical, Molecular, and Functional Genetics of Bardet-Biedl Syndrome Alison Ross Ross, Alison Philip L. Beales Beales, Philip L. Josephine Hill Hill, Josephine 147

10 Borjeson-Forssman-Lehmann Syndrome Joanna Crawford Crawford, Joanna Michael Partington Partington, Michael Mark Corbett Corbett, Mark Karen Lower Lower, Karen Jozef Geez Geez, Jozef 187

11 Cohen Syndrome Kate E. Chandler Chandler, Kate E. Forbes D. C. Manson Manson, Forbes D. C. 201

12 Prader-Willi Syndrome Rachel Wevrick Wevrick, Rachel 223

13 Syndromes with Obesity Philip L. Beales Beales, Philip L. Raoul Hennekam Hennekam, Raoul 251

Index 279

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