Genetics of Obesity Syndromes

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Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients.
The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.

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Editorial Reviews

Doody's Review Service
Reviewer: Ronald N. Cohen, MD (University of Chicago Medical Center)
Description: The first of this book's three sections is a general discussion of obesity. Monogenic forms of obesity are covered in the second section and, finally, syndromes that include obesity are reviewed. This field is rapidly advancing, yet this book explores all major genetic forms of obesity in detail.
Purpose: The purpose is to review the major genetic causes of diabetes, and to serve as a reference for people studying obesity or taking care of patients with obesity. Much has been learned in recent years about the genetic basis of obesity, and this book does an excellent job of reviewing and discussing these issues.
Audience: Although written for medical students, clinicians, nutritionists, molecular biologists, and geneticists, this book would most likely be particularly useful for geneticists and/or clinical specialists (such as endocrinologists) caring for patients with obesity. It will also serve as an outstanding reference for researchers with an interest in obesity. The authors are leaders in this field.
Features: In-depth discussions cover the important genetic causes of obesity, including leptin and leptin receptor mutations, POMC deficiency, PC1 mutations, and MC4R deficiency. In addition, the book reviews a variety of multiorgan syndromes that include obesity, among them GNAS-associated syndromes, Bardet-Biedl syndrome, and Prader-Willi syndrome. There are a number of excellent illustrations, including photographs of patients with these disorders.
Assessment: This is a great reference for both monogenic and multisystem genetic syndromes associated with obesity. This is the first book that I've seen that covers this increasingly important topic in such detail. It is an important book for anyone interested in obesity and its causes.
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Product Details

  • ISBN-13: 9780195300161
  • Publisher: Oxford University Press, USA
  • Publication date: 8/29/2008
  • Series: Oxford Monographs on Medical Genetics Series
  • Pages: 304
  • Sales rank: 1,471,025
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.00 (d)

Table of Contents

Pt. I Introduction

1 Introduction Philip L. Beales Beales, Philip L. I. Sadaf Farooqi Farooqi, I. Sadaf 3

2 A Practical Guide to the Clinical Assessment and Investigation of Obesity I. Sadaf Farooqi Farooqi, I. Sadaf 25

Pt. II Nonsyndromic Obesity

3 Human Leptin and Leptin Receptor Deficiency I. Sadaf Farooqi Farooqi, I. Sadaf Stephen O'Rahilly O'Rahilly, Stephen 37

4 Pro-opiomelanocortin Deficiency Heiko Krude Krude, Heiko Annette Gruters Gruters, Annette 49

5 Prohormone Convertase 1 Robert S. Jackson Jackson, Robert S. 63

6 Human Melanocortin 4 Receptor Deficiency I. Sadaf Farooqi Farooqi, I. Sadaf Stephen O'Rahilly O'Rahilly, Stephen 81

Pt. III Syndromlc Obesity

7 Albright Hereditary Osteodystrophy, Pseudohypoparathyroidism, and Other GNAS-Associated Syndromes Louise C. Wilson Wilson, Louise C. 91

8 The Clinical and Molecular Genetics of Alstrom Syndrome Gayle B. Collin Collin, Gayle B. Jan D. Marshall Marshall, Jan D. Jurgen K. Naggert Naggert, Jurgen K. Patsy M. Nishina Nishina, Patsy M. 133

9 The Clinical, Molecular, and Functional Genetics of Bardet-Biedl Syndrome Alison Ross Ross, Alison Philip L. Beales Beales, Philip L. Josephine Hill Hill, Josephine 147

10 Borjeson-Forssman-Lehmann Syndrome Joanna Crawford Crawford, Joanna Michael Partington Partington, Michael Mark Corbett Corbett, Mark Karen Lower Lower, Karen Jozef Geez Geez, Jozef 187

11 Cohen Syndrome Kate E. Chandler Chandler, Kate E. Forbes D. C. Manson Manson, Forbes D. C. 201

12 Prader-Willi Syndrome Rachel Wevrick Wevrick, Rachel 223

13 Syndromes with Obesity Philip L. Beales Beales, Philip L. Raoul Hennekam Hennekam, Raoul 251

Index 279

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