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Doody's Review ServiceReviewer: Ronald N. Cohen, MD (University of Chicago Medical Center)
Description: The first of this book's three sections is a general discussion of obesity. Monogenic forms of obesity are covered in the second section and, finally, syndromes that include obesity are reviewed. This field is rapidly advancing, yet this book explores all major genetic forms of obesity in detail.
Purpose: The purpose is to review the major genetic causes of diabetes, and to serve as a reference for people studying obesity or taking care of patients with obesity. Much has been learned in recent years about the genetic basis of obesity, and this book does an excellent job of reviewing and discussing these issues.
Audience: Although written for medical students, clinicians, nutritionists, molecular biologists, and geneticists, this book would most likely be particularly useful for geneticists and/or clinical specialists (such as endocrinologists) caring for patients with obesity. It will also serve as an outstanding reference for researchers with an interest in obesity. The authors are leaders in this field.
Features: In-depth discussions cover the important genetic causes of obesity, including leptin and leptin receptor mutations, POMC deficiency, PC1 mutations, and MC4R deficiency. In addition, the book reviews a variety of multiorgan syndromes that include obesity, among them GNAS-associated syndromes, Bardet-Biedl syndrome, and Prader-Willi syndrome. There are a number of excellent illustrations, including photographs of patients with these disorders.
Assessment: This is a great reference for both monogenic and multisystem genetic syndromes associated with obesity. This is the first book that I've seen that covers this increasingly important topic in such detail. It is an important book for anyone interested in obesity and its causes.