Genetics Primer for Exercise Science and Health / Edition 1

Genetics Primer for Exercise Science and Health / Edition 1

by Stephen Roth
     
 

The text maintains a practical focus while providing updates on current research findings and exploring how genetics may affect clinical practice and sport performance training.

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Overview

The text maintains a practical focus while providing updates on current research findings and exploring how genetics may affect clinical practice and sport performance training.

Product Details

ISBN-13:
9780736063432
Publisher:
Human Kinetics Publishers
Publication date:
05/02/2007
Series:
Primers for Exercise Science Series
Edition description:
New Edition
Pages:
192
Product dimensions:
8.50(w) x 10.90(h) x 0.50(d)
Age Range:
18 Years

Table of Contents

Preface
Acknowledgments

Part I. Basics of Genetics

Chapter 1. Individual Differences: The Role of Genetics in Exercise Science and Health

-Hidden Aspect of Average Values

-Why Do We See Variation in a Physical Trait?

-Summary

-Learning Aids
Chapter 2. DNA, RNA, and Protein

-Basic Cell Biology

-DNA

-Our Genetic Material as Chromosomes

-Special Focus: The Human Genome Project

-RNA

-Amino Acids and Proteins

-Structure of Genes

-Summary

-Learning Aids
Chapter 3. Transcription, Translation, and the Genetic Code

-Moving From DNA to RNA: Transcription

-Posttranscriptional Modifications of RNA

-Moving From RNA to Protein: Translation

-Posttranslational Modifications of Proteins

-Genetic Code

-Summary

-Learning Aids
Chapter 4. Moving Genetic Material to the Next Generation

-Basic Reproduction

-Sex Cell Production and Meiosis

-Special Focus: Mitosis Versus Meiosis

-Chromosomal Recombination

-Mendelian Inheritance Patterns

-Summary

-Learning Aids
Chapter 5. Heritability and the Basics of Genetic Variation

-Familial Resemblance: Genes and Environment

-Heritability as a Measure of Genetic Contribution

-Special Focus: Twin and Family Studies

-Genetic Variation

-Types of Genetic Variation

-Special Focus: Labeling Polymorphisms

-How Genetic Variation Can Influence Physical Traits

-How Do Polymorphisms Arise? Genetic Variation and Evolution

-Summary

-Learning Aids
Chapter 6. Genetic Variation and Disease

-Mendelian Disease Genetics

-Special Focus: Muscular Dystrophy

-Complex Disease

-Special Focus: Obesity as a Complex Trait

-Gene x Environment Interactions

-Gene x Gene Interactions

-Summary

-Learning Aids
Chapter 7. Linkage Disequilibrium, Haplotype, and Environmental Interaction

-Recombination Revisited

-Linkage Disequilibrium

-Linkage Analysis in Families

-Haplotype: Combinations of Neighboring Alleles

-Special Focus: The International HapMap Project

-Diplotype: Combinations of Haplotypes

-Gene x Environment Interaction Revisited

-An Introduction to Epigenetics

-Summary

-Learning Aids
Part II. Research Design and Methods

Chapter 8. Getting Started: Basic Skills for Genetics Research

-Is Genetic Variation Important for My Trait of Interest?

-Using PubMed

-Interpreting Existing Literature

-Identifying and Selecting Candidate Genes and Polymorphisms

-Using Genome Databases

-Summary

-Learning Aids
Chapter 9. Issues in Study Design and Analysis

-How Genetics Necessarily Alters Study Design

-Typical Study Designs

-Subject Recruitment

-Geographical Ancestry

-Special Focus: Race in Genetics

-Prospective Versus Retrospective

-Statistical Approaches

-Interpretation of Results: Association versus Cause and Effect

-Summary

-Learning Aids
Chapter 10. Basic Laboratory Methods in Genetics

-DNA from Blood or Cheek Cells

-Polymerase Chain Reaction (PCR)

-Genotyping with Restriction Enzymes

-Genotyping with Fluorescent Tags

-Special Focus: DNA Microarrays

-DNA Sequencing

-Summary

-Learning Aids
Part III. Current Findings and Extensions of Genetics Research

Chapter 11. Current Research Findings in the Genetics of Exercise Science and Health

-Overview of Current Findings

-Special Focus: The Human Gene Map for Performance and Health-Related Fitness Phenotypes

-ACTN3 and Muscular Performance

-ApoE and Cognitive Impairment

-ACE and Sport Performance

-Myostatin and Muscle Mass

-Summary

-Learning Aids
Chapter 12. Personalized Medicine

-Genetics and Complex Disease Revisited

-Promise and Limitations of Personalized Medicine

-Special Focus: Pharmacogenomics

-Genetics in Nutrition and Exercise Prescription

-Genetics in Disease Prevention

-Summary

-Learning Aids
Chapter 13. Ethical Challenges in Genetics and Society

-Ethical, Legal, and Social Implications of Genomics Gene Therapy for Disease Treatment

-Special Focus: Stem Cells

-Genetics in Sport: Genetic Testing and Gene Doping for Performance

-Summary

-Learning Aids
Appendix A: Answers to Review Questions
Appendix B: Evolution and Hardy-Weinberg Equilibrium
Glossary
Bibliography
Index
About the Author

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