Genomic Medicine: Articles from the New England Journal of Medicine / Edition 1

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"Fifteen years ago, many questioned the wisdom of sequencing the human genome. There were concerns not only about the technical feasibility of such an effort, but also that its scientific worth would prove too modest to warrant the investment of human and financial capital that the project would require. This collection of essays stands as eloquent testimony to those who overcame such doubts to create, nurture, and finish the sequencing of the human genome in April 2003, a date that will forever stand out in human history. The wide and public availability of the human genome sequence and the other tools spawned by the Human Genome Project have helped to create an unparalleled era of biomedical discovery. It has opened up new avenues for the understanding of the biology of human health and disease. Many of these avenues remain to be fully explored, but this volume already demonstrates that information about genetics and genomics is increasingly permeating our clinical approach to patients."—from the Foreword by Dr. Elias Zerhouni

For more than a century, knowledge about the role of genes has been gradually reshaping perceptions of our health and of ourselves. From Mendel's work with plants and Watson and Crick's model of DNA's double-helix structure to the recent decoding of the human genome, the tremendous advances in our ability to analyze and interpret gene sequences are revolutionizing many aspects of medicine. Genomic Medicine collects and updates an acclaimed series of articles published in the pages of the New England Journal of Medicine since November 2002 that together provide an authoritative and comprehensive overview of the latest developments in the field of medical genetics and an exploration of where these advances might take medicine over the next decade.

Beginning with a fundamental primer and a useful glossary of terms, the book offers the latest information on the use of genetics to screen, diagnose, and treat a wide variety of diseases, including breast and ovarian cancer and cardiovascular, Alzheimer, and Parkinson disease. Also included are discussions of population screening, pharmacogenetics, and the ethical, legal, and social dimensions of genomic medicine. Edited by leaders in the field, written by experts from around the globe, and brimming with full-color illustrations, Genomic Medicine is an indispensable guide to the full potential of the DNA-based transformation of medicine.

Johns Hopkins University Press

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Editorial Reviews

Human Reproduction and Genetic Ethics

An indispensable guide to the full potential of the DNA-based transformation of medicine.

Human Genetics - Andrew P. Read

The editors have assembled a fine set of short, readable and highly authoritative articles by eminent authors. The book is beautifully produced and will give an accessible entry into genetic medicine to its target audience of non-specialist clinicians. Readers of this journal will need no persuading of the fascination and ever growing importance of genetic medicine and these themes are well communicated.

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Product Details

  • ISBN-13: 9780801879791
  • Publisher: Johns Hopkins University Press
  • Publication date: 1/28/2004
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 208
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.49 (d)

Meet the Author

Francis S. Collins, M.D., Ph.D., is director of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health. He shepherded the Human Genome Project to completion in 2003. Alan E. Guttmacher, M.D., is deputy director of the NHGRI and director of its Office of Policy, Communication, and Education. Jeffrey M. Drazen, M.D., is Editor-in-Chief of the New England Journal of Medicine.

Johns Hopkins University Press

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Table of Contents

List of Contributors
1 Getting Ready for Gene-Based Medicine 1
2 Genomic Medicine - A Primer 3
3 Genetic Testing 14
4 Population Screening in the Age of Genomic Medicine 28
5 Inheritance and Drug Response 41
6 Pharmacogenomics - Drug Disposition, Drug Targets, and Side Effects 54
7 Pharmacogenetics in the Laboratory and the Clinic 70
8 Hereditary Colorectal Cancer 74
9 Alzheimer's Disease and Parkinson's Disease 93
10 Molecular Diagnosis of the Hematologic Cancers 106
11 Breast and Ovarian Cancer 118
12 Cardiovascular Disease 131
13 Ethical, Legal, and Social Implications of Genomic Medicine 148
14 Genomics as a Probe for Disease Biology 158
15 Welcome to the Genomic Era 166
Index 171
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