Genomic Regulatory Systems: In Development and Evolution / Edition 1

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Overview

Genomic Regulatory Systems is about the gene regulatory programs built into the DNA of every animal. Such programs control the process of development, and changes in their organization are the underlying cause of animal evolution.
The book takes a "genome's eye" view of the mechanism of spatial gene regulation and of developmental processes ranging from simple forms of embryogenesis to elegant mechanisms of pattern formation. Throughout, discussions of development and evolution are intertwined. The text takes an in-depth look at how the hardwired control systems of the genome work and offers an explanation for evolutionary change in animal body plans.
Eric H. Davidson is a major contributor to the field of developmental biology and has long been interested in the relationship between development and evolution. Genomic Regulatory Systems is authoritative but easy-to-read and will appeal to professionals and readers from a wide variety of scientific backgrounds.
Contents Include
*Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

Audience: Students and professionals in biology, cell biology, and molecular biology. Also, any person with a general interest in evolution.

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Editorial Reviews

Andre Adoutte
This is a fantastic book!...No one better than Eric Davidson was able to synthesize the whole field of transcriptional regulation as it relates to development...Two points are specially striking in this book, the strength of the intellectual thread running through the book and the scholarly treatment of the most recent and pertinent data...To add to the pleasure, the book is loaded with beautiful documents, illustrating both primary experimental results and remarkable synthetic diagrams.
David J. Galas
The book is a serious scientific exposition, crafted with care, beautifully illustrated and very timely. Researchers and students alike will find the book a rich and challenging source of ideas, questions and linkages to the literature. It is the integrated genomic view of the subject, however, that makes the book so valuable. We should never think of evolution and embryogenesis in the same way again.
Science
Eric Davidson has made seminal contributions to our understanding of transcriptional regulation and, over 30 years ago, was among the first to comment on the importance of studying the evolution of gene networks.
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Product Details

  • ISBN-13: 9780122053511
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 1/28/2001
  • Edition number: 1
  • Pages: 261
  • Product dimensions: 7.76 (w) x 9.53 (h) x 0.87 (d)

Meet the Author

Eric H. Davidson is the Norman Chandler Professor of Cell Biology at the California Institute of Technology and a Member of the National Academy of Sciences.

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Table of Contents

Preface ix
1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution
The Regulatory Apparatus Encoded in the DNA
The Genes and Gene Regulatory Components of Animal Genomes 2
Overview of Regulatory Architecture 7
Gene Regulatory Functions in Development 11
The Regulatory Demands of Development 11
Pattern Formation 13
Terminal Differentiation 16
Genomic Regulatory Sequence and the Evolution of Morphological Features 18
Regulatory Evolution, and Evolution in General 19
Bilaterian Phylogeny 20
2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression
Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events 26
Spatial Repression in cis-Regulatory specification 28
Two Very Different Examples of Similar Import 28
cis-Regulatory Design for Autonomous Modular Function 35
The Generality of Repression 41
Downstream of Specification 44
Some Examples 45
At the Beginning of Embryogenesis 46
Polyfunctional Downstream Modules 48
The "Power" of the cis-Regulatory Module 49
Diverse cis-Regulatory Outputs from a Simple Input 50
Direct Integration of Noncoincident Spatial Inputs 52
A cis-Regulatory Logic Device 54
3. Regulation of Direct Cell-Type Specification in Early Development
The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes 64
Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo 66
The Definitive Territories of the Embryo 66
Early Transcriptional Activation of Cell Type-specific Genes 71
Initial Regulatory Processes 74
Multiple Inputs for Endomesoderm Specification 75
Regulatory Mechanisms Controlling Specification in Ascidian Embryos 81
Territorial Specification 81
Mechanisms and Pathways in Mesoderm Specification 85
Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification 92
Endoderm Specification 93
The Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification 96
Short Summary: Quality of Type 1 Regulatory Networks 101
4. The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
The Evolutionary Significance of "Pattern Formation" 103
The First Step: Transcriptional Definition of the Domain of the Body Part 105
Morphological Pieces and Regulatory Subpatterns 110
Heart Parts 110
Forelimb and Hindlimb Buds 111
Transcriptional Domains in the Gut Endoderm 115
Patterns in the Developing Hindbrain 117
Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs 121
Glimpses of How It Works 122
Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs 123
Patterning the Heart Progenitor Field in Drosophila 129
Encoding Hindbrain Regulatory Patterns 131
The Role of Signaling 140
The Last Routines: Calling in Differentiation Programs 146
Specification of Peripheral Nervous System Elements in the Drosophila Wing 147
Installation of Cell Type-specific Differentiation Programs in the Pituitary 152
Concluding Remark 153
5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions 158
hox Gene Functions and Cooptions of the hox Cluster Patterning System 164
A Specific Case of A/P Patterning: How a hox Gene Does Its Job 166
Evolutionary Changes in hox Gene Expression in the Arthropods 167
Off the A/P Axis 174
Colinear Expression of hox Genes in the Somatocoels of Sea Urchin Larvae 178
Small Changes 183
Evolutionary Origins of Body Parts 188
Polarity in Body Part Evolution 188
The Case of pax6 and Some Other Amazing Examples 191
Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks 201
References 203
Index 245
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