Genomics: The Science and Technology Behind the Human Genome Project / Edition 1

Genomics: The Science and Technology Behind the Human Genome Project / Edition 1

by Charles R. Cantor, Cassandra L. Smith
     
 

ISBN-10: 0471599085

ISBN-13: 9780471599081

Pub. Date: 03/28/1999

Publisher: Wiley

In Genomics, Charles R. Cantor, former director of the Human Genome Pr oject, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the fi eld of molecular genetics and biotechnology. Written with a range of r eaders in mindyfrom chemists and biologists to computer scientists and engineersythe

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Overview

In Genomics, Charles R. Cantor, former director of the Human Genome Pr oject, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the fi eld of molecular genetics and biotechnology. Written with a range of r eaders in mindyfrom chemists and biologists to computer scientists and engineersythe book begins with a review of the basic properties of DN A and the chromosomes that package it in cells. The authors describe t he three main techniques used in DNA analysisyhybridization, polymeras e chain reaction, and electrophoresisyand present a complete explorati on of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular g enetics to a wide audience, the book brings the scientific community c loser to the ultimate goal of understanding the biological function of DNA.

Product Details

ISBN-13:
9780471599081
Publisher:
Wiley
Publication date:
03/28/1999
Series:
Baker Lecture Series, #6
Edition description:
New Edition
Pages:
632
Product dimensions:
7.24(w) x 10.16(h) x 1.36(d)

Table of Contents

DNA Chemistry and Biology.

A Genome Overview at the Level of Chromosomes.

Analysis of DNA Sequences by Hybridization.

Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification.

Principles of DNA Electrophoresis.

Genetic Analysis.

Cytogenetics and Pseudogenetics.

Physical Mapping.

Enhanced Methods for Physical Mapping.

DNA Sequencing: Current Tactics.

Strategies for Large-Scale DNA Sequencing.

Future DNA Sequencing Without Length Fractionation.

Finding Genes and Mutations.

Sequence-Specific Manipulation of DNA.

Results and Implications of Large-Scale DNA Sequencing.

Appendix.

Index.

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