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A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers
In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features:
"...written by a leading researcher in this evolving field who is also a co-inventor of some of the technology... covers methods in researching the genome and explains how to look at, map out, and splice DNA."
DNA Chemistry and Biology.
A Genome Overview at the Level of Chromosomes.
Analysis of DNA Sequences by Hybridization.
Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification.
Principles of DNA Electrophoresis.
Cytogenetics and Pseudogenetics.
Enhanced Methods for Physical Mapping.
DNA Sequencing: Current Tactics.
Strategies for Large-Scale DNA Sequencing.
Future DNA Sequencing Without Length Fractionation.
Finding Genes and Mutations.
Sequence-Specific Manipulation of DNA.
Results and Implications of Large-Scale DNA Sequencing.
Posted February 12, 2001
The material in this book represents a coverage of genomics technology that appears to be both wide and deep. With the latter I refer to the authors' welcome practice of delving into the physical chemistry and probability associated with their subjects, without avoiding mathematical expressions yet still without forcing them upon a molecular biologist reader. If it were not for the poor quality of the editing I wouldn't grumble much about the book's high price. I count at least 70 errors in spelling, punctuation, grammar, and matches between citations and references. Particularly painful are errors like 'Edmond' for Edman degradation, and repeatedly 'Geimsa' for Giemsa staining -- one's left wondering what errors were not so obvious.Was this review helpful? Yes NoThank you for your feedback. Report this reviewThank you, this review has been flagged.