Genomics: The Science and Technology Behind the Human Genome Project / Edition 1

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1999 Hard cover New. Sewn binding. Cloth over boards. 624 p. Contains: Illustrations. Baker Lecture Series.

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In Genomics, Charles R. Cantor, former director of the Human Genome Pr oject, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the fi eld of molecular genetics and biotechnology. Written with a range of r eaders in mindyfrom chemists and biologists to computer scientists and engineersythe book begins with a review of the basic properties of DN A and the chromosomes that package it in cells. The authors describe t he three main techniques used in DNA analysisyhybridization, polymeras e chain reaction, and electrophoresisyand present a complete explorati on of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular g enetics to a wide audience, the book brings the scientific community c loser to the ultimate goal of understanding the biological function of DNA.

"...written by a leading researcher in this evolving field who is also a co-inventor of some of the technology... covers methods in researching the genome and explains how to look at, map out, and splice DNA."

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Editorial Reviews

From the Publisher
"this book is to be highly recommended..."(Human Genetics, May 2000)
Human Genetics
this book is to be highly recommended...
Overviews the theoretical principles and practical methods underlying the DOE Human Genome Project and modern molecular genetics and biotechnology. The book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. Cantor and Smith (biomedical engineering, Boston University) then describe the three main techniques used in DNA analysis<-->hybridization, polymerase chain reaction, and electrophoresis<-->and explore DNA mapping in its many different forms. For chemists, biologists, computer scientists, engineers, and physicians. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780471599081
  • Publisher: Wiley
  • Publication date: 2/28/1999
  • Series: Baker Lecture Series , #6
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 632
  • Product dimensions: 7.24 (w) x 10.16 (h) x 1.36 (d)

Meet the Author

CHARLES R. CANTOR, formerly principal scientist of the DOE HumanGenome Project, is the Chief Scientific Officer of Sequenom, Inc.,in San Diego. Dr. Cantor is on leave from Boston University, wherehe is Professor of Biomedical Engineering and Director of theCenter for Advanced Biotechnology.
CASSANDRA L. SMITH is Deputy Director of the Center for AdvancedBiotechnology and Professor of Biomedical Engineering, Biology, andPharmacology at Boston University.

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Table of Contents

DNA Chemistry and Biology.

A Genome Overview at the Level of Chromosomes.

Analysis of DNA Sequences by Hybridization.

Polymerase Chain Reaction and Other Methods for In Vitro DNAAmplification.

Principles of DNA Electrophoresis.

Genetic Analysis.

Cytogenetics and Pseudogenetics.

Physical Mapping.

Enhanced Methods for Physical Mapping.

DNA Sequencing: Current Tactics.

Strategies for Large-Scale DNA Sequencing.

Future DNA Sequencing Without Length Fractionation.

Finding Genes and Mutations.

Sequence-Specific Manipulation of DNA.

Results and Implications of Large-Scale DNA Sequencing.



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  • Anonymous

    Posted February 12, 2001

    Killer science, editing could be better

    The material in this book represents a coverage of genomics technology that appears to be both wide and deep. With the latter I refer to the authors' welcome practice of delving into the physical chemistry and probability associated with their subjects, without avoiding mathematical expressions yet still without forcing them upon a molecular biologist reader. If it were not for the poor quality of the editing I wouldn't grumble much about the book's high price. I count at least 70 errors in spelling, punctuation, grammar, and matches between citations and references. Particularly painful are errors like 'Edmond' for Edman degradation, and repeatedly 'Geimsa' for Giemsa staining -- one's left wondering what errors were not so obvious.

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