Geographical and Environmental Epidemiology: Methods for Small-Area Studies / Edition 1

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Overview


This book is the first to address both the theoretical and practical issues which arise when describing the geographical distribution of disease and investigating apparent disease clusters. Requirements in terms of population data, disease incidence and mortality are considered and related to the scale at which a study is being carried out. Statistical methods are reviewed for large scale correlation studies, intermediate scale smoothing exercises, and small scale clustering investigations, and the problems of interpretation are discussed. Problems of measuring environmental exposures at different scales are also reviewed. These issues are then related to current practice via a comprehensive set of case studies which include a large correlation study in China, clustering of asthma attacks, the Sellafield-leukemia cluster, environmental clusters of mesothelioma in Turkey, the investigation of disease following the industrial accident at Sevesco, and a multi-source study of cancer incidence around incinerators.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Product Details

  • ISBN-13: 9780192622358
  • Publisher: Oxford University Press
  • Publication date: 9/12/1996
  • Edition description: REPRINT
  • Edition number: 1
  • Pages: 404
  • Product dimensions: 6.13 (w) x 9.19 (h) x 0.84 (d)

Table of Contents

List of contributors
Pt. I Introduction 1
1 Geographical epidemiology and ecological studies 3
2 Small-area studies: purpose and methods 14
3 Health and the environment: the significance of chemicals and radiation 22
Pt. II Data, computational methods, and mapping 35
4 Mortality data 37
5 Cancer incidence data for adults 51
6 Cancer incidence data for children 63
7 Congenital anomalies 72
8 Specialized registers 89
9 Population counts in small areas 96
10 Use of routine data in studies of point sources of environmental pollution 106
11 Socio-economic confounding 115
12 Use of record linkage in small-area studies 125
13 Confidentiality 132
14 Practical approaches to disease mapping 141
15 Estimating environmental exposure 151
16 Mapping environmental exposure 158
Pt. III Statistical methods 177
Introduction 179
17 Statistical methods for geographical correlation studies 181
18 Bayesian methods for mapping disease risk 205
19 Statistical methods for analysing point-source exposures 221
20 Some comments on methods for investigating disease risk around a point source 231
21 Methods for the assessment of disease clusters 238
Pt. IV Studies of health and the environment 251
22 Environmental epidemiology: a historical perspective 253
23 Guidelines for the investigation of clusters of adverse health events 264
24 Studies of disease clustering: problems of interpretation 278
Pt. V Case studies 287
Introduction 288
25 Childhood leukaemia around the Sellafield nuclear plant 291
26 The epidemic of respiratory cancer associated with erionite fibres in the Cappadocian region of Turkey 310
27 Soya bean as a risk factor for epidemic asthma 323
28 The Seveso accident 342
29 Cancer of the larynx and lung near incinerators of waste solvents and oils in Britain 359
30 A study of geographical correlations in China 368
Index 373
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