Ghrelin

Overview

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volumecovers ghrelin, andhas chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice.

  • Contains quality chapters authored by leaders in the field
  • Has ...
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Ghrelin

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Overview

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volumecovers ghrelin, andhas chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice.

  • Contains quality chapters authored by leaders in the field
  • Has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice
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Product Details

  • ISBN-13: 9780123812728
  • Publisher: Elsevier Science
  • Publication date: 10/9/2012
  • Pages: 512
  • Product dimensions: 6.20 (w) x 9.10 (h) x 1.00 (d)

Meet the Author

Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.

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Table of Contents

  1. History of GHS and ghrelin
    1. History To The Discovery Of Ghrelin
    2. Orphan Gpcrs And Methods For Identifying Their Ligands
    3. Purification Of Rat And Human Ghrelins
    4. Variety of Acyl Modifications in Mammalian Ghrelins
    5. Determination Of Non-Mammalian Ghrelin
    6. Molecular forms of ghrelin and Measuring of the concentrations

    7. Morphological Analysis Of Ghrelin Neurons In The Hypothalamus
    8. High-Performance Liquid Chromatography Analysis Of Hypothalamic Ghrelin
    9. Standard Sample Collections For Blood Ghrelin Measurements
    10. Enzymes for processing of ghrelin

    11. From Ghrelin to Ghrelin’s O Acyl Transferase
    12. Enzymatic Characterization Of Goat, Ghrelin O-Acyltransferase
    13. The Study Of Ghrelin Deacylation Enzymes
    14. Synthesis of ghrelin agonists and antagonists

    15. Synthesis? Of Ghrelin:Chemical Synthesis And Semi-Synthesis For Large-Scale Preparation Of Modified Peptides
    16. Ghrelin O-Acyltransferase Assays And Inhibition
    17. Action of ghrelin

    18. Model-Based Evaluation Of Growth Hormone Secretion
    19. Ghrelin In The Control Of Energy, Lipid And Glucose Metabolism
    20. Ghrelin And The Vagus Nerve
    21. Measurement of amp-activated protein kinase (ampk) activity and expression In response to ghrelin
    22. Ghrelin And Gastrointestinal Movement
    23. Ghrelin Acylation By Ingestion Of Medium-Chain Fatty Acids
    24. Islet ß-cell Ghrelin Signaling For Inhibition Of Insulin Secretion
    25. Rikkunshito As A Ghrelin Enhancer
    26. Tg and KO mice of ghrelin

    27. Thermogenic Characterization Of Ghrelin Receptor Null Mice
    28. Transgenic Mice Over-Expressing Ghrelin Or Ghrelin Analog
    29. Clinical application of ghrelin

    30. Therapeutic Potential Of Ghrelin In Restricting-Type Anorexia Nervosa
    31. Clinical Application Of Ghrelin For Chronic Respiratory Diseases
    32. Clinical Trial Of Ghrelin Synthesis Administration For Upper Gi Surgery
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