Glutathione S-Transferases: Structure, Function and Clinical Implications / Edition 1

Glutathione S-Transferases: Structure, Function and Clinical Implications / Edition 1

by Gerard J. Mulder, W.H. M. Peters, H. Nieuwenhuyse, G. J. Mulder
     
 

Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzymeSee more details below

Overview

Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme

Product Details

ISBN-13:
9780748403318
Publisher:
Taylor & Francis
Publication date:
05/23/1996
Edition description:
New Edition
Pages:
250
Product dimensions:
6.90(w) x 9.90(h) x 0.79(d)

Related Subjects

Meet the Author

Table of Contents

List of Senior Authors
Preface
Acknowledgements
A Fortunate Life
1Glutathione Transferases with Novel Properties Generated by Protein Engineering and Phage Display
2Structure, Mechanism and Evolution of Class Mu and Sigma Glutathione Transferases13
3A Substrate and Protein Model for Rat Class Mu Glutathione S-Transferase 4-423
4Crystallographic Studies of Pi- and Theta-Class Glutathione Transferases39
5Microsomal Glutathione Transferase Dimensions
6Class Theta Glutathione S-Transferases in Rats, Mice and Guinea Pigs57
7Regulation of Rat Class Alpha Glutathione S-Transferases and the Contribution of GST Yc[subscript 2] to Resistance to Aflatoxin B[subscript 1]73
8Regulation of Glutathione Transferase P-Expression during Hepatocarcinogenesis of the Rat89
9Regulation of Glutathione S-Transferases: Clues from a Worm, a Virus, and a Mouse with Hepatitis
10A New Group of Glutathione S-Transferases with a Protective Role against Lipid Peroxidation
11Modulation of Glutathione Transferase P1-1 Activity125
12Transcriptional Regulation of the Human Pi-Class Glutathione S-Transferase Gene133
13Irreversible Inhibition of Cytosolic Glutathione S-Transferases143
14Molecular Genetic Characterization of Human Glutathione Synthetase153
15Glutathione Conjugation in vivo in Rat and Man: Glutathione Dependence and Selective Inhibition of Conjugation163
16The Relationship and Regulation of Glutathione in Cancer Cells Resistant to Chemotherapy173
17GST-Targeted Drug Candidates187
18Transport of Glutathione S-Conjugates from Cancer Cells: Function and Structure of the GS-X Pump199
19Effects of Glutathione S-Transferase Inhibitors on Detoxification Gene Expression213
20Characterization of the Polymorphic Human Class-mu GSTM1-0 Deletion227
21Glutathione S-Transferases and Cancer Susceptibility239
22Glutathione S-Transferases as Biomarkers of Organ Viability and Damage249
Subject Index259

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