Glutathione S-Transferases: Structure, Function and Clinical Implications / Edition 1

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Overview

Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme

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Product Details

  • ISBN-13: 9780748403318
  • Publisher: CRC Press
  • Publication date: 5/23/1996
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 250
  • Product dimensions: 6.90 (w) x 9.90 (h) x 0.79 (d)

Table of Contents

List of Senior Authors
Preface
Acknowledgements
A Fortunate Life
1 Glutathione Transferases with Novel Properties Generated by Protein Engineering and Phage Display
2 Structure, Mechanism and Evolution of Class Mu and Sigma Glutathione Transferases 13
3 A Substrate and Protein Model for Rat Class Mu Glutathione S-Transferase 4-4 23
4 Crystallographic Studies of Pi- and Theta-Class Glutathione Transferases 39
5 Microsomal Glutathione Transferase Dimensions
6 Class Theta Glutathione S-Transferases in Rats, Mice and Guinea Pigs 57
7 Regulation of Rat Class Alpha Glutathione S-Transferases and the Contribution of GST Yc[subscript 2] to Resistance to Aflatoxin B[subscript 1] 73
8 Regulation of Glutathione Transferase P-Expression during Hepatocarcinogenesis of the Rat 89
9 Regulation of Glutathione S-Transferases: Clues from a Worm, a Virus, and a Mouse with Hepatitis
10 A New Group of Glutathione S-Transferases with a Protective Role against Lipid Peroxidation
11 Modulation of Glutathione Transferase P1-1 Activity 125
12 Transcriptional Regulation of the Human Pi-Class Glutathione S-Transferase Gene 133
13 Irreversible Inhibition of Cytosolic Glutathione S-Transferases 143
14 Molecular Genetic Characterization of Human Glutathione Synthetase 153
15 Glutathione Conjugation in vivo in Rat and Man: Glutathione Dependence and Selective Inhibition of Conjugation 163
16 The Relationship and Regulation of Glutathione in Cancer Cells Resistant to Chemotherapy 173
17 GST-Targeted Drug Candidates 187
18 Transport of Glutathione S-Conjugates from Cancer Cells: Function and Structure of the GS-X Pump 199
19 Effects of Glutathione S-Transferase Inhibitors on Detoxification Gene Expression 213
20 Characterization of the Polymorphic Human Class-mu GSTM1-0 Deletion 227
21 Glutathione S-Transferases and Cancer Susceptibility 239
22 Glutathione S-Transferases as Biomarkers of Organ Viability and Damage 249
Subject Index 259
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