Glycobiology and the Brain

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Editorial Reviews

Brings together contributions from carbohydrate research in the areas of neurobiology, neuropathology, and neuropharmacology, highlighting the importance of carbohydrates in the understanding of neurobiology, the development of neuropathology, and the commercialization of neuropharmacological agents. Chapters focus on aspects of the present and future application of the study of glycobiology to brain biochemistry, from basic research on glycoconjugates to practical identification of carbohydrates in neuropathological studies and the relevance of structural studies in a pharmacological perspective. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780080422831
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 2/28/1994
  • Series: Studies in Neurosciences Ser., #10
  • Edition description: 1st ed
  • Pages: 304

Table of Contents

Preface: Glycobiology and Neuropharmaceuticals
1 Lectins in Human Brain 3
2 Gangliosides and Brain Development 19
3 Glycoconjugates and Anionic Sites in the Blood-Brain Barrier 37
4 N-CAM and L1: Role of Glycoproteins of the Immunoglobulin Superfamily in Nervous System Development 63
5 Control by Glycosphingolipids of Cell Growth, Cell Adhesion, and Transmembrane Signaling 83
6 Glycoprotein Specificity and Diversity 97
7 Glycolipids in Alzheimer Disease 125
8 Lectin Histochemistry of the Brain Cortex in Alzheimer's Disease 141
9 The Role of Glycosphingolipids in Peripheral Neuropathies and Related Disorders 155
10 Extracellular Matrix Constituents in Alzheimer's Amyloid Deposits 179
11 Carbohydrate Histochemistry of Amyloid Plaques in Alzheimer's Disease 197
12 Exogenous Gangliosides in Neuronal Repair Processes: Interaction with Neurotrophic Factors 213
13 Brain and Hyaluronic Acid 229
14 Recent Developments in the MS and NMR Analysis of Gangliosides 245
15 Gangliosides of the Vertebrate Nervous System - An Overview of the Chemical Structures 275
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