Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development / Edition 1

Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development / Edition 1

by Ana Martinez
     
 

ISBN-10: 0471770019

ISBN-13: 9780471770015

Pub. Date: 10/13/2006

Publisher: Wiley

Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with

Overview

Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It’s a great reference for researchers in drug design and development.

Product Details

ISBN-13:
9780471770015
Publisher:
Wiley
Publication date:
10/13/2006
Series:
Wiley Series in Drug Discovery and Development Series, #3
Pages:
354
Product dimensions:
6.44(w) x 9.33(h) x 0.94(d)

Table of Contents

Foreword: The Origins of GSK-3.

Preface.

Acknowledgments.

Contributors.

Abbreviations. 

PART I: CELLULAR FUNCTIONS OF GSK-3.

1. Glycogen Synthase Kinase-3 - an Introductory Synopsis  .

2. Glycogen-Synthase-Kinase-β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective.

3. Role of GSK3/Shaggy in neuronal cell biology.

4. The Crystal Structures of Glycogen Synthase Kinase 3.

5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3.

PART II: GSK3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY.

6. GSK-3, a Key Player in Alzheimer’s Disease.

7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments.

8. GSK3 and Stem Cells.

9. Glycogen Synthase Kinase-3: role in Neurodegeneration and Neuroprotection.

10. Protein Kinase Inhibitors. Assay Development.

11. Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies.

PART III: GSK-3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL.

12. Lithium, the Seminal GSK3 Inhibitor.

13. Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418.

14. TDZD’s: Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors.

15. 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors.

16. Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors.

Index.

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >