Glycopeptides and Related Compounds / Edition 1

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Overview

"Presents state-of-the-art methods for the synthesis, analysis, and conformational investigation of glycoproteins and glycopeptides. Discusses the history of glycopeptide synthesis, therapeutic applications, and the future of research."

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Warren Knudson, PhD (Rush Medical College of Rush University)
Description: As its name implies, this book is concerned with the synthesis, analysis, and application of small-sized glycans/glycopeptides. However, the primary focus (8 of 15 chapters) appears to be the review of current chemical methods for synthesis.
Purpose: One purpose of the book is to bolster interest and excitement in oligosaccharide-related chemistry, something that has been lacking in comparison to fields such as nucleic acid and protein/peptide-based chemistry. Although the book achieves its goal of convincing the reader that glycopeptide synthesis is now a feasible undertaking, the use of practical chemical approaches still appears difficult, with many parts of which are still best supplemented by or more efficiently completed via enzymatic reactions.
Audience: The audience described by the authors consists of glycobiologists, graduate students, practitioners in organic chemistry and biochemistry and, pharmaceutical scientists. Although the book is a mix, with certain chapters more relevant to particular audiences, the book would seem of particular importance to a more select group such as pharmaceutical scientists. A large emphasis is given to synthesis for practical applications. Although a practicing glycobiologist may be interested in obtaining a particular pure, synthetic glycan (analogous to obtaining pure synthetic oligonucleotide sequences), they might not be as interested in knowing of advances in the chemistry of its synthesis.
Features: The book has several useful features. Because of the considerable depth of technical details in some chapters, abbreviation tables have been included. All figures are black-and-white, but, given that most of the figures are chemical structures or pathways, color enhancement is not necessary. Precursor, intermediate, and product structures are clearly bold highlighted in figures and within the text.
Assessment: This book brings together in one text the successful approaches and problems in the field of glycopeptide synthesis and their practical application. Its fault is the narrow audience of those who will really appreciate its full value.
Journal of Medicinal Chemistry
This is a very special book... "Every school with a graduate program in organic chemistry should have this book in its library.
European Peptide Society Newsletter
...a valuable resource.
Biochemistry (Moscow)
...a valuable manual for specialists in the fields of biochemistry, bioorganic chemistry, synthetic chemistry, pharmacology, and interdisciplinary sciences.
Warren Knudson
As its name implies, this book is concerned with the synthesis, analysis, and application of small-sized glycans/glycopeptides. However, the primary focus (8 of 15 chapters) appears to be the review of current chemical methods for synthesis. One purpose of the book is to bolster interest and excitement in oligosaccharide-related chemistry, something that has been lacking in comparison to fields such as nucleic acid and protein/peptide-based chemistry. Although the book achieves its goal of convincing the reader that glycopeptide synthesis is now a feasible undertaking, the use of practical chemical approaches still appears difficult, with many parts of which are still best supplemented by or more efficiently completed via enzymatic reactions. The audience described by the authors consists of glycobiologists, graduate students, practitioners in organic chemistry and biochemistry and, pharmaceutical scientists. Although the book is a mix, with certain chapters more relevant to particular audiences, the book would seem of particular importance to a more select group such as pharmaceutical scientists. A large emphasis is given to synthesis for practical applications. Although a practicing glycobiologist may be interested in obtaining a particular pure, synthetic glycan (analogous to obtaining pure synthetic oligonucleotide sequences), they might not be as interested in knowing of advances in the chemistry of its synthesis. The book has several useful features. Because of the considerable depth of technical details in some chapters, abbreviation tables have been included. All figures are black-and-white, but, given that most of the figures are chemical structures or pathways,color enhancement is not necessary. Precursor, intermediate, and product structures are clearly bold highlighted in figures and within the text. This book brings together in one text the successful approaches and problems in the field of glycopeptide synthesis and their practical application. Its fault is the narrow audience of those who will really appreciate its full value.
Booknews
A review of the methodologies and history of glycopeptide synthesis, therapeutic applications, and future research featuring state-of-the-art investigational techniques. The 15 discussions examine enzymatic synthesis of oligosaccharides and glycopeptides, the applications of solid base technologies, strategies used in the synthesis of the peptide component of glycopeptides, the synthesis of glycosylphosphatidylinositol syltransferase inhibitors, the application of nuclear magnetic resonance methods to several classes of glycoconjugates, and how alterations in the structure of mucins elaborated by epithelial cells expose novel epitopes that can serve as a basis for vaccines against cancer. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824795313
  • Publisher: Taylor & Francis
  • Publication date: 5/28/1997
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 784
  • Product dimensions: 6.25 (w) x 9.25 (h) x 0.75 (d)

Table of Contents

Glycopeptides and glycoproteins - their past, present, and future; recent advances in the synthesis of glycopeptides; enzymatic synthesis of oligosaccharides and glycopeptides; chemical synthesis of glycoprotein glycans; synthesis of oligosaccharides and glycopeptides on insoluble and soluble supports; chemical synthesis of the peptide moiety of glycopeptides; synthesis of glycosylphosphatidylinositol anchors; analysis of GPI protein anchors and related glycolipids; synthesis of intermediates in the dolichol pathway of protein glycosylation; synthesis of inhibitors of the glycosidases and glycosyltransferases involved in the biosynthesis and degradation of glycoproteins; use of permethylation with GC-MS for linkage and sequence analysis of oligosaccharides historical perspectives and recent developments; structural determination of protein-bound oligosaccharides by mass spectrometry; approaches to the structural determination of oligosaccharides and glycopeptides by NMR; conformational studies of glycoprotein glycans using NMR and molecule dynamics; glycopeptides in the immunotherapy of cancer.

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