Goodman & Gilman's The Pharmacological Basis of Therapeutics, Eleventh Edition [NOOK Book]

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A Doody's Core Title ESSENTIAL PURCHASE!

5 STAR DOODY'S REVIEW!
"The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains...

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Goodman & Gilman's The Pharmacological Basis of Therapeutics, Eleventh Edition

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Overview

A Doody's Core Title ESSENTIAL PURCHASE!

5 STAR DOODY'S REVIEW!
"The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains the gold standard of pharmacology textbooks....The print version should be on the reference shelf and the digital version on the computer desktop of all practicing pharmacologists, pharmacists, and physicians."--Doody's Review Service

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Editorial Reviews

From The Critics
Reviewer: Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description: The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains the gold standard of pharmacology textbooks.
Purpose: The editors have done a remarkable job of condensing information from a rapidly expanding field to slightly reduce the number of pages from the previous edition while adhering to the principles of the original authors and retaining the completeness for which the book is known. The editors have standardized the organization to provide readers with essential physiology and basic pharmacology while providing the kinds of details a physician needs to know under easily identifiable headings. The editors have done a marvelous job in achieving the high standards expected by readers.
Audience: Although this publication may be too extensive for most students to read cover to cover while taking a pharmacology course, it should be a required resource for all who study, research, teach, or practice any facet of healthcare involving the use of medications.
Features: The 11th edition continues to provide the most comprehensive, current, and authoritative information on drugs. This latest version has new chapters on drug transporters, drug metabolism, and pharmacogenetics. The print version comes with a non-transferable subscription to an online digital version. Each drug in the digital version is hyperlinked to Gold Standards, Clinical Pharmacology Online, an online database. PDA downloads are available. In my view, this is by far the best electronic database available and includes information on FDA approval and black box warnings, mechanism of action, pharmacokinetics, chemical structure, pill photographs, indications, contraindications, adverse effects, dosages, patient education and much more. References in the digital version are also hyperlinked to PubMed.
Assessment: The print version should be on the reference shelf and the digital version on the computer desktop of all practicing pharmacologists, pharmacists, and physicians.
The Permanente Journal

There are few technical books that remain in a leadership position for 65 years. The Pharmacological Basis of Therapeutics is one. Physicians, teachers, and medical students have voted for Goodman & Gilman with their feet and with their pocketbooks for over six decades. The question is not whether this is an important and useful text, but why? ...While Goodman & Gilman is no quick-read, it is surprisingly clearly written, logical and interesting. It is also an awesome realization to see how much one never knew, added to what one knew but forgot.


4 Stars! from Doody
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Product Details

  • ISBN-13: 9780071608916
  • Publisher: McGraw-Hill Companies, The
  • Publication date: 8/23/2005
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 11
  • File size: 58 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Laurence L. Brunton, PhD

Professor of Pharmacology and Medicine

University of California, San Diego

Laurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers.

John S. Lazo, PhD

Professor and Chairman

Department of Pharmacology

University of Pittsburgh School of Medicine

Under John Lazo's leadership as Chairman, the Department of Pharmacology is regarded as one of the leading academic programs in the United States. He has published extensively in the field of cancer pharmacology.

Keith Parker, MD, PhD

Professor of Internal Medicine and Pharmacology

Division of Endocrinology

Department of Internal Medicine

University of Texas Southwestern School of Medicine

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Table of Contents

Sect. I General Principles 1
Introduction 1
1 Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination 3
2 Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect 31
3 Principles of Therapeutics 45
4 Principles of Toxicology and Treatment of Poisoning 67
5 Gene Therapy 81
Sect. II Drugs Acting at Synaptic and Neuroeffector Junctional Sites 113
6 Neurotransmission: The Autonomic and Somatic Motor Nervous Systems 115
7 Muscarinic Receptor Agonists and Antagonists 155
8 Anticholinesterase Agents 175
9 Agents Acting at the Neuromuscular Junction and Autonomic Ganglia 193
10 Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists 215
11 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists 269
Sect. III Drugs Acting on the Central Nervous System 291
12 Neurotransmission and the Central Nervous System 293
13 History and Principles of Anesthesiology 321
14 General Anesthetics 337
15 Local Anesthetics 367
16 Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium 385
17 Hypnotics and Sedatives 399
18 Ethanol 429
19 Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders 447
20 Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania 485
21 Drugs Effective in the Therapy of the Epilepsies 521
22 Treatment of Central Nervous System Degenerative Disorders 549
23 Opioid Analgesics 569
24 Drug Addiction and Drug Abuse 621
Sect. IV Autacoids; Drug Therapy of Inflammation 643
Introduction 643
25 Histamine, Bradykinin, and their Antagonists 645
26 Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor 669
27 Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout 687
28 Drugs Used in the Treatment of Asthma 733
Sect. V Drugs Affecting Renal and Cardiovascular Function 755
29 Diuretics 757
30 Vasopressin and Other Agents Affecting the Renal Conservation of Water 789
31 Renin and Angiotensin 809
32 Drugs Used for the Treatment of Myocardial Ischemia 843
33 Antihypertensive Agents and the Drug Therapy of Hypertension 871
34 Pharmacological Treatment of Heart Failure 901
35 Antiarrhythmic Drugs 933
36 Drug Therapy for Hypercholesterolemia and Dyslipidemia 971
Sect. VI Drugs Affecting Gastrointestinal Function 1003
37 Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease 1005
38 Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome 1021
39 Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease 1037
Sect. VII Chemotherapy of Parasitic Infections 1059
Introduction 1059
40 Drugs Used in the Chemotherapy of Protozoal Infections: Malaria 1069
41 Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections 1097
42 Drugs Used in the Chemotherapy of Helminthiasis 1121
Sect. VIII Chemotherapy of Microbial Diseases 1141
43 Antimicrobial Agents: General Considerations 1143
44 Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections 1171
45 Antimicrobial Agents: Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics 1189
46 Antimicrobial Agents: The Aminoglycosides 1219
47 Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents 1239
48 Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy 1273
49 Antimicrobial Agents: Antifungal Agents 1295
50 Antimicrobial Agents: Antiviral Agents (Nonretroviral) 1313
51 Antimicrobial Agents: Antiretroviral Agents 1349
Sect. IX Chemotherapy of Neoplastic Diseases 1381
Introduction 1381
52 Antineoplastic Agents 1389
Sect. X Drugs Used for Immunomodulation 1461
53 Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants 1463
Sect. XI Drugs Acting on the Blood and the Blood-Forming Organs 1485
54 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins 1487
55 Anticoagulant, Thrombolytic, and Antiplatelet Drugs 1519
Sect. XII Hormones and Hormone Antagonists 1539
56 Pituitary Hormones and Their Hypothalamic Releasing Factors 1541
57 Thyroid and Antithyroid Drugs 1563
58 Estrogens and Progestins 1597
59 Androgens 1635
60 Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones 1649
61 Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas 1679
62 Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds 1715
Sect. XIII The Vitamins 1745
Introduction 1745
63 Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid 1753
64 Fat-Soluble Vitamins: Vitamins A, K, and E 1773
Sect. XIV Dermatology 1793
65 Dermatological Pharmacology 1795
Sect. XV Ophthalmology 1819
66 Ocular Pharmacology 1821
Sect. XVI Toxicology 1849
67 Heavy Metals and Heavy-Metals Antagonists 1851
68 Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides 1877
App. I Principles of Prescription Order Writing and Patient Compliance 1903
App. II Design and Optimization of Dosage Regimens: Pharmacokinetic Data 1917
Index 2025
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