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Doody's Review ServiceReviewer: Rachel R Chennault, PhD (American College of Clinical Pharmacy)
Description: This book examines the various properties and functions of G protein-coupled receptors (GPCRs) that make them useful targets for therapeutic intervention and addresses advances in screening approaches to identify potential drug candidates that modulate cellular events upon activation of G protein-coupled receptors.
Purpose: Because our understanding of how G protein-coupled receptors mediate cellular responses is constantly evolving, the purpose of this book is to update readers on recent advances in the field, particularly with respect to the utility of GPCRs as a target class in molecular pharmacology. This book details recent developments in GPCR research and lays the necessary foundation upon which the discovery of new drug products involving GPCRs may proceed.
Audience: The intended audience of scientists includes chemists, pharmacologists, and biologists in both the academic and industrial sectors. Additionally, the presentation of the fundamental concepts of GPCR biology by the authors, who are recognized experts in the GPCR field, is likely to be appreciated by students of pharmacology.
Features: The book begins with a historical perspective on the concept of drug receptors, detailing the processes by which new theories about GPCR functions evolved. Subsequent chapters discuss the appropriateness of both traditional and high-throughput screening techniques to discover modulators of G protein-coupled receptors as a means to develop novel therapeutics. Color illustrations pertaining to these methods and GPCR function are particularly instructive.
Assessment: This is a unique resource for navigating the field of GPCR research. Although other books nay have detailed descriptions of GPCR function, screening methodology, and pharmacology (e.g., G Protein-coupled Receptors: Molecular Pharmacology, Vauquelin and von Mentzer (John Wiley & Sons, 2007), this one devotes an entire chapter to examining hereditary human diseases that arise by GPCR inactivating mutations, expanding the context of GPCR research into potential therapies involving pharmacological chaperones.