Greene's Protective Groups in Organic Synthesis / Edition 4

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Overview

An indispensable reference for any practicing synthetic organic or medicinal chemist, this book continues the tradition of Greene’s as comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology.
• Presents valuable material, on the application of protective groups in organic chemistry, that is not easily found by casual searching
• Helps chemists to plan, investigate, and carry out organic syntheses in an efficient manner
• Adds over 2800 new references to update since the publication of the last edition
• Reviews of the prior edition: "An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007) "...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007) "...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)
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Editorial Reviews

From the Publisher
"An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007)

"...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007)

"...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

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Product Details

  • ISBN-13: 9780471697541
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 11/3/2006
  • Edition description: Revised Edition
  • Edition number: 4
  • Pages: 1110
  • Sales rank: 1,470,695
  • Product dimensions: 6.48 (w) x 9.21 (h) x 2.23 (d)

Meet the Author

Peter G.M. Wuts is a Distinguished Scientist at Kalexsyn, Inc. in Kalamazoo, Michigan.

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Table of Contents

Preface to the Fifth Edition

Preface to the Fourth Edition

Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition

Abbreviations

1. The Role of Protective Groups in Organic Synthesis

2. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

Ethers

Esters

Protection for 1,2- and 1,3-Diols

3. Protection for Phenols and Catechols

Protection for Phenols

Protection for Catechols

Protection for 2-Hydroxybenzenethiols

4. Protection for the Carbonyl Group

Acetals and Ketals

Miscellaneous Derivatives

Monoprotection of Dicarbonyl Compounds

5. Protection for the Carboxyl Group

Esters

Amides and Hydrazides

6. Protection for the Thiol Group

Thioethers

Thioesters

Miscellaneous Derivatives

7. Protection for the Amino Group

Carbamates

Amides

Special -NH Protective Groups

Protection for Imidazoles, Pyrroles, and Indoles

Protection for Amides

8. Protection for the Alkyne -CH

9. Protection for the Phosphate Group

Some General Methods of Phosphate Ester Formation

Removal of Protective Groups from Phosphorous

Alkyl Phosphates

Phosphates Cleaved by Cyclodesesterification

Benzyl Phosphates

Phenyl Phosphates

Photochemically Cleaved Phosphate Protective Groups

Amidates

Miscellaneous Derivatives

10. Reactivities, Reagents, and Reactivity Charts

Reactivities

Reagents

Reactivity Charts

Index

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