Growth Factors and Psychiatric Disorders / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$159.00
Used and New from Other Sellers
Used and New from Other Sellers
from $132.01
Usually ships in 1-2 business days
(Save 37%)
Other sellers (Hardcover)
  • All (8) from $132.01   
  • New (6) from $158.99   
  • Used (2) from $132.01   

Overview

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.

Read More Show Less

Product Details

  • ISBN-13: 9780470516041
  • Publisher: Wiley
  • Publication date: 5/13/2008
  • Series: Novartis Foundation Symposia Series , #692
  • Edition number: 1
  • Pages: 258
  • Product dimensions: 6.00 (w) x 9.20 (h) x 0.70 (d)

Meet the Author

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Chair: MOSES V CHAO, Skirball Institute of Biomolecular Medicine, New York, USA

Read More Show Less

Table of Contents

Symposium on Growth factors and psychiatric disorders, held at the Novartis Foundation, London, 20–22 March 2007.

Editors: Derek J. Chadwick (Organizer) and Jamie Goode.

This symposium is based on a proposal made by Moses Chao.

Moses Chao Chair’s introduction.

Daniel C. Javitt Phenomenology, aetiology and treatment of  schizophrenia.

Discussion.

Jonathan Flint, Sagiv Shifman, Marcus Munafo and Richard Mott Genetic variants in major depression.

Discussion.

Eero Castrén and Tomi Rantamäki Neurotrophins in depression and antidepressant effects.

Discussion.

Jinbo Fan and Pamela Sklar Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism.

Discussion.

David A. Talmage Mechanisms of neuregulin action.

Discussion.

General discussion I.

H. Akil, S. J. Evans, C. A. Turner, J. Perez, R. M. Myers, W. E. Bunney, E. G. Jones, S. J. Watson and other members of the Pritzker Consortium The fibroblast growth factor family and mood disorders.

Discussion.

Jay N. Giedd, Rhoshel K. Lenroot, Philip Shaw, Francois Lalonde, Mark Celano, Samantha White, Julia Tossell, Anjene Addington and Nitin Gogtay Trajectories of anatomic brain development as a phenotype.

Discussion.

Bai Lu and Keri Martinowich Cell biology of BDNF and its relevance to schizophrenia.

Discussion.

Enrico Tongiorgi and Gabriele Baj Functions and mechanisms of BDNF mRNA trafficking.

Discussion.

Amar Sahay and René Hen Hippocampal neurogenesis and depression.

Discussion.

Andrés Buonanno, Oh-Bin Kwon, Leqin Yan, Carmen Gonzalez, Marines Longart, Dax Hoffman and Detlef Vullhorst Neuregulins and neuronal plasticity: possible relevance in schizophrenia.

Discussion.

Zhe-Yu Chen, Kevin Bath, Bruce McEwen, Barbara Hempstead and Francis Lee Impact of genetic variant BDNF (Val66Met) on brain structure and function.

Discussion.

General discussion II.

D. Malaspina, M. Perrin, K. R. Kleinhaus, M. Opler and S. Harlap Growth and schizophrenia: aetiology, epidemiology and epigenetics.

Discussion.

Luiz M. Camargo, Qi Wang and Nicholas J. Brandon What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?

Discussion.

Michael Spedding and Pierre Gressens Neurotrophins and cytokines in neuronal plasticity.

Discussion.

Moses Chao Closing remarks.

Index of contributors.

Subject index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)