Growth Factors and the Cardiovascular System / Edition 1

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This book is the first to cover the growing area of research in growth factors and which devotes itself completely to the role of the growth factors in the cardiovascular system. It contains contributions by the leading experts in the field with an emphasis on the effects of growth factors on the cardiac myocyte, angiogenesis and atherosclerosis. Clinical and therapeutic implications of growth factors in cardiovascular disease are reviewed. Growth Factors and Cardiovascular System provides a comprehensive review together with new information that should be valuable to investigators and clinicians alike.

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Product Details

  • ISBN-13: 9780792324010
  • Publisher: Springer US
  • Publication date: 3/5/1999
  • Series: Developments in Cardiovascular Medicine Series, #147
  • Edition description: 1993
  • Edition number: 1
  • Pages: 370
  • Product dimensions: 0.94 (w) x 9.21 (h) x 6.14 (d)

Table of Contents

Foreword; B. Swynghedauw. Preface; P. Cummins. Introduction. 1. Growth factors: in vivo function and mechanism of action; C.-H. Heldin, L. Claesson-Welsh, K. Miyazono, B. Westermark. Section one: Growth Factors in the Heart. 2. Fibroblast and transforming growth factors in the heart: a role for cardiac growth? P. Cummins, A.K. El Amrani, F. El Amrani. 3. Growth factors and the cardiac extra-cellular matrix; L. Rappaport, J.L. Samuel. Section two: Growth Factors and the Cardiac Myocyte. 4. Transforming growth factor beta: Localisation and possible functional roles in cardiac myocytes; A.B. Roberts, M.B. Sporn. 5. Basic fibroblast growth factor in cardiac myocytes: expression and effects; E. Kardami, R.R. Padua, K.B.S. Pasumarthi, Lei Liu, B.W. Doble, S.E. Davey, P.A. Cattini. 6. Growth factor signal transduction in the cardiac myocyte: Functions of the serum response element; M.D. Schneider, T. Brand, R.J. Schwartz, W.R. MacLellan. 7. Effects of growth factors on human cardiac myocytes; B.I. Goldman, J. Wurzel. Section three: Growth Factors and Angiogenesis. 8. Growth factors and development of coronary collaterals; H.H. Sharma, R. Zimmerman. 9. The role of growth factors in angiogenesis; R.J. Schott, L.A. Morrow. Section four: Growth Factors and Atherosclerosis. 10. Atherosclerosis and platelet-derived growth factors; G.A.A. Ferns, C. Rutherford. 11. Effects of transforming growth factor beta on vascular smooth muscle cell growth; P.I. Weissberg, D.J. Grainger, J.C. Metcalfe. 12. Some aspects of growth factor signal transduction in vascular smooth muscle cells; A.C. Newby, N.P.J. Brindle. 13. Basic FGFs role in smooth muscle cell proliferation: A basis for molecular atherectomy; W. Casscells, D.A. Lappi, A. Baird. Section five: Growth Factors and Cardiovascular Disease: Clinical and Therapeutic Implications. 14. Role of transforming growth factor &bgr; in cardioprotection of the ischemic-reperfused myocardium; A.M. Lefer. 15. Platelet-derived growth factor release after angioplasty; P. Macke Consigny. 16. Platelet-derived growth factor receptor activity induced by vascular injury; G.E. Bilder. 17. Growth factors and hypertension: Implications of growth factor function in vascular remodelling; A.K. El Amrani, F. El Amrani, P. Cummins. 18. Transforming growth factor &bgr; and carcinoid heart disease; J. Waltenberger. Section six: Growth Factor Effects on the Myocardium. 19. Adrenergic stimulation and growth factor activity; C.S. Long, P.C. Simpson. 20. Effects of transforming growth factor &bgr; on cardiac fibroblasts; M. Eghbali. 21. Transforming growth factor &bgr;'s and cardiac development; R.J. Akhurst, M. Dickson, F.A. Millan. Index.

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