GTPases / Edition 1

GTPases / Edition 1

by Alan Hall
     
 

ISBN-10: 0199637458

ISBN-13: 9780199637454

Pub. Date: 03/28/2000

Publisher: Oxford University Press, USA

GTPases are molecular switches that are used to control biochemical pathways. This book describes the properties and cellular roles of all the major families of GTPases. All cells use GTPases to regulate the delivery of amino acids to the ribosome during protein synthesis, but eukaryotes, with their complex and compartmentalized environment, have exploited the

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Overview

GTPases are molecular switches that are used to control biochemical pathways. This book describes the properties and cellular roles of all the major families of GTPases. All cells use GTPases to regulate the delivery of amino acids to the ribosome during protein synthesis, but eukaryotes, with their complex and compartmentalized environment, have exploited the versatility of GTPases to a much greater extent. In particular, GTPases play a central role in regulating signal transduction pathways activated by extracellular signals and in regulating the trafficking of proteins beetween different organelles. It is not surprising, therefore, that GTPases have become a center of attention for those studying the control of proliferation, differentiation, cell polarity, cell movement, and vesicle and protein trafficking. This book provides a complete guide to this area and should be essential reading for cell and molecular biologists, biochemists and geneticists interested in these contemporary problems.

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Product Details

ISBN-13:
9780199637454
Publisher:
Oxford University Press, USA
Publication date:
03/28/2000
Series:
Frontiers in Molecular Biology Series, #24
Pages:
360
Product dimensions:
9.70(w) x 7.20(h) x 1.00(d)

Table of Contents

List of contributors
Abbreviations
1A genomics approach to cytokine discovery1
2Cytokine signal transduction20
3Cytokine networks49
4Cytokines and the Th1/Th2 paradigm71
5Chemokines103
6Cytokines and cytokine receptors encoded by viruses126
7Genetic variation in cytokines and relevance to inflammation and disease152
8Therapeutic manipulation of the cytokine network174
Index191

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