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GTPases / Edition 1

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Overview

GTPases are molecular switches that are used to control biochemical pathways. This book describes the properties and cellular roles of all the major families of GTPases. All cells use GTPases to regulate the delivery of amino acids to the ribosome during protein synthesis, but eukaryotes, with their complex and compartmentalized environment, have exploited the versatility of GTPases to a much greater extent. In particular, GTPases play a central role in regulating signal transduction pathways activated by extracellular signals and in regulating the trafficking of proteins beetween different organelles. It is not surprising, therefore, that GTPases have become a center of attention for those studying the control of proliferation, differentiation, cell polarity, cell movement, and vesicle and protein trafficking. This book provides a complete guide to this area and should be essential reading for cell and molecular biologists, biochemists and geneticists interested in these contemporary problems.

The book contains black-and-white illustrations.

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Editorial Reviews

Eugene A. Davidson
Signaling between cells is a critical function in many areas of biology. The agents involved (several hundred), many of which are cytokines, represent a growing class of molecules with multiple bioactivities. This volume contains timely reviews of the current status of the field. The purpose is to provide an overview of the current status of the role of cytokines. This objective is largely met by the editor. This book will be of interest to investigators working in the general areas of signal transduction, immunology, malignant disease, and regulation. In an initial chapter genomic approaches to cytokine identification are described, and material on cytokine signaling and networks follows. The relationship of cytokines to Th1/Th2 cells is discussed which leads to several chapters on cytokine receptors encoded by viruses, therapeutic approaches, and relationships to disease states including malignancy. Each chapter is accompanied by a thorough bibliography of considerable value to those wishing primary sources. Given the large increase in cytokine numbers and the complexities of their interrelationships, this volume fills a useful need.
From The Critics
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: Signaling between cells is a critical function in many areas of biology. The agents involved (several hundred), many of which are cytokines, represent a growing class of molecules with multiple bioactivities. This volume contains timely reviews of the current status of the field.
Purpose: The purpose is to provide an overview of the current status of the role of cytokines. This objective is largely met by the editor.
Audience: This book will be of interest to investigators working in the general areas of signal transduction, immunology, malignant disease, and regulation.
Features: In an initial chapter genomic approaches to cytokine identification are described, and material on cytokine signaling and networks follows. The relationship of cytokines to Th1/Th2 cells is discussed which leads to several chapters on cytokine receptors encoded by viruses, therapeutic approaches, and relationships to disease states including malignancy. Each chapter is accompanied by a thorough bibliography of considerable value to those wishing primary sources.
Assessment: Given the large increase in cytokine numbers and the complexities of their interrelationships, this volume fills a useful need.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780199637454
  • Publisher: Oxford University Press, USA
  • Publication date: 3/28/2000
  • Series: Frontiers in Molecular Biology Series , #24
  • Edition number: 1
  • Pages: 360
  • Product dimensions: 9.70 (w) x 7.20 (h) x 1.00 (d)

Table of Contents

List of contributors
Abbreviations
1 A genomics approach to cytokine discovery 1
2 Cytokine signal transduction 20
3 Cytokine networks 49
4 Cytokines and the Th1/Th2 paradigm 71
5 Chemokines 103
6 Cytokines and cytokine receptors encoded by viruses 126
7 Genetic variation in cytokines and relevance to inflammation and disease 152
8 Therapeutic manipulation of the cytokine network 174
Index 191
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