Guidebook to the Secretory Pathway / Edition 1

Guidebook to the Secretory Pathway / Edition 1

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by J. Rothblatt
     
 

The late 1970s and early 1980s saw a boom in research establishing molecular details related to secretory protein modifications such as signal peptide processing, proenzyme proteolytic maturation, glycosylation, and oligosaccharide modification. This timely new resource compiles what is known about the secretory pathway. The book charts how much of the current

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Overview

The late 1970s and early 1980s saw a boom in research establishing molecular details related to secretory protein modifications such as signal peptide processing, proenzyme proteolytic maturation, glycosylation, and oligosaccharide modification. This timely new resource compiles what is known about the secretory pathway. The book charts how much of the current progress in the field derives from the development of cell-free systems that reproduce individual transport steps, the identification of proteins associated with vesicular carriers, and the isolation of mutants and characterization of gene products that mediate protein translocation and secretion. Guidebook to the Secretory Pathway will be invaluable to researchers and students of cell and molecular biology.

Product Details

ISBN-13:
9780198599418
Publisher:
A Sambrook and Tooze Publication at Oxford University Press
Publication date:
03/28/2002
Series:
Guidebook Series
Edition description:
New Edition
Pages:
320
Product dimensions:
7.50(w) x 9.13(h) x 0.72(d)

Table of Contents

Foreword, R. Schekman
Entering the Secretory Pathway, J. Rothblatt
PART I: Protein Secretion in E. Coli
PART II: Translocation and Maturation of Newly-Synthesized Polypeptides in the ER of Eukaryotic Cells
Introduction, J. Rothblatt
A: Protein Translocation and Maturation in the Yeast ER
B: Protein Translocation and Maturation in the Mammalian ER
PART III: Protein Machines Catalyzing ER to Golgi Transport
Introduction, W.E. Balch
A: ER to Golgi Transport in Yeast
B: ER to Golgi Transport in Mammalian Cells
PART IV: Membrane Traffic in the Golgi and to the Cell Surface
Introduction, Peter Novick
A: Yeast Proteins Involved in Membara Traffic in the Golgi and to the Cell Surface
B: Mammalian Proteins Involved in Membrane Traffic in the Golgi and to the Cell Surface
PART V: Membrane Traffic to the Lysome/Vacuole
Introduction, T.H. Stevens
A: Membrane Traffic to the Yeast Vacuole
B: Membrane Traffic to the Mammalian Lyosome

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