Handbook of Biotransformations of Aromatic Compounds

Handbook of Biotransformations of Aromatic Compounds

by B.L. Goodwin, B. L. Goodwin, Goodwin Goodwin
     
 

ISBN-10: 0415271762

ISBN-13: 9780415271769

Pub. Date: 11/28/2004

Publisher: Taylor & Francis

Aromatic compounds don't actually (necessarily) smell nice, they are, in fact, chemicals which contain a ring structure - compounds such as plant and animal hormones, enzymes, drugs, agricultural compounds, environmental contaminants etc. When these are taken into the body (human or animal) they are metabolised, ie., broken down. The resulting products of this

…  See more details below

Overview

Aromatic compounds don't actually (necessarily) smell nice, they are, in fact, chemicals which contain a ring structure - compounds such as plant and animal hormones, enzymes, drugs, agricultural compounds, environmental contaminants etc. When these are taken into the body (human or animal) they are metabolised, ie., broken down. The resulting products of this breakdown may themselves have effects in the body, which is why scientists across the range of life sciences need to know what happens to these compounds once they are inside us. The Handbook of Biotransformations of Aromatic Compounds examines 25,000 such compounds and describes their metabolism in humans and experimental animals. The author has brought together a staggering amount of data, citing all the major relevant references from 1972 till 2000.

Product Details

ISBN-13:
9780415271769
Publisher:
Taylor & Francis
Publication date:
11/28/2004
Pages:
2128
Product dimensions:
0.85(w) x 1.10(h) x 2.88(d)

Table of Contents

PART 1
Alphabetical Listing of Aromatic Compounds

PART 2
REACTIONS INVOLVING THE FORMATION AND DEGRADATION OF THE AROMATIC NUCLEUS
Aromatization of 6-membered carbon and heterocyclic rings
Formation of carbon ring systems
Formation of heterocyclic ring systems
Polymerization reactions
Reactions involving carbon ring fission
Reactions involving heterocyclic ring fission
Dearomatization
Ring expansion

OXIDATIONS AND REDUCTIONS INVOLVING THE AROMATIC NUCLEUS AND NON-ORGANIC SUBSTITUENTS
Hydroxylation of the aromatic nucleus
Formation of quinones and analogues from catechols, quinols and other precursors
Free radicals from phenols
Oxidation of nuclear amino groups and analogues
Oxidation of heterocyclic amines
Reduction of nitro groups and analogues
Oxidation and reduction of sulphur atoms
Reduction of quinones and analogues
Halogens and the aromatic nucleus
Epoxide formation and reduction
Deamination of arylamines without hydroxylation
Dehydroxylation of phenols
Nitro group addition and removal

OXIDATIONS AND REDUCTIONS OF SUBSTITUENT SIDE CHAINS AND NON-AROMATIC RING SYSTEMS (WITHOUT ALTERING CHAIN LENGTH)
Hydroxylation of the carbon side-chain
Alkyl oxidation to ketone
Oxidations and reductions of alcohols, aldehydes and ketones
Reductions of acids
Deamination
Oxidative removal of substituents on amino groups
Oxidations and reductions involving nitrogen atoms
O-Dealkylation
Oxidations and reductions of non-aromatic ring systems
Sulphur replacement
Dehydroxylation
Side chain halogenation
Oxidative rearrangement

FORMATION AND DEGRADATION OF SIDE-CHAINS
Side-Chain Formation
Decarboxylation of phenolic groups without hydroxylation
Decarboxylation reactions of side-chains
Other reactions involving side-chain shortening and removal
Chain lengthening reactions

CONJUGATION AND SUBSTITUTION REACTIONS
Ester formation
Sulphamate formation
Glycoside formation
Conjugation of thiols
Formation of amides and substituted amides
Phosphorylation reactions
Ether formation
N-alkylation
Silane anhydrides

ELIMINATION OF SUBSTITUENTS
Ester hydrolysis
Hydrolysis of glycosides
Hydrolysis of amides
Hydrolysis of phosphates
Miscellaneous reactions

TRANSFER REACTIONS
Transamination
Isomerization
Migrations
Racemization

FORMATION AND REACTIONS OF NON-ARYL DOUBLE AND TRIPLE BONDS
Double and triple bond formation
Reactions of double bonds

HYDRATION OF EPOXIDES

LIGHT-FORMING REACTIONS

INDEX

BIBLIOGRAPHY

Read More

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >