Handbook of Drug Monitoring Methods: Therapeutics and Drugs of Abuse / Edition 1

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In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is a comprehensive handbook on all aspects of drug monitoring.
Purpose: The purpose of this book is twofold. The first is to provide a quick and handy technology reference for the bench technologist performing drug testing. The second is to provide a reference which clinical users of drug test results can use to interpret the results. Both of these worthy objectives are well met by this book.
Audience: This has broad appeal. Of course it would appeal to anyone actively measuring drug levels (i.e., clinical laboratory scientists, toxicologists, clinical chemists). It would also appeal to anyone interested in how such testing is performed and the pitfalls in interpreting results (students or practitioners in any medical discipline or allied health field, poison control centers, concerned parents, etc.). The editor is internationally recognized for his expertise in this area, and all authors are very credible authorities.
Features: This book packs more information than you would think possible in a 7 x 10 x 1 inch book. The 22 chapters cover pretty much anything you might ever want to know about drug monitoring. Early chapters discuss basic introductory matters (i.e., methods, when to measure free versus bound drug, etc.) followed by chapters focusing on drug classes (e.g., digoxin, antidepressants, immunosuppresives). Then a group of chapters discusses issues commonly encountered with drug testing - interferents (lipis, hemolysis, bilirubin), herb interactions, different specimen types (blood versus urine versus saliva versus hair), specimen adulterants and interpretation of results. I especially appreciated the chapter on clinical false positive drug test results, which was full of useful information. Where else could you learn that use of Vicks inhalers can potentially yield a false positive amphetamine result? Or what adulterants are frequently used to obscure evidence of drug abuse? Or what do you need to be mindful of when testifying about drug levels you measured for legal cases? You've got to buy the book to get these answers. These are exactly the questions I get most frequently, and the answers are all here in one convenient location. Of note, this book would be a nice cornerstone to a small group of specialty books collectively covering the majority of toxicology and drugs of abuse testing: Narayan and Young's Effects of Herbs and Natural Products on Clinical Laboratory Tests (AACC Press, 2007), Hammett-Stabler and DasGupta's Therapeutic Drug Monitoring Data, 3rd edition (AACC Press, 2007), Jenkins and Goldberger's On-Site Drug Testing (Humana Press, 2002), and Wong and Tse's Drugs of Abuse: Body Fluid Testing (Humana Press, 2005).
Assessment: This is a very nice addition to the field of drug testing and monitoring. If for nothing else, get it to impress your colleagues when you can definitively answer the frequent question, "How many poppy seed bagels can I eat without having my urine test positive for drugs of abuse?"
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Product Details

  • ISBN-13: 9781588297808
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/28/2007
  • Edition description: 2008
  • Edition number: 1
  • Pages: 446
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.60 (d)

Table of Contents

Preface     v
Contributors     ix
Introduction to Therapeutic Drug Monitoring   Amitava Dasgupta     1
Monitoring Free Drug Concentration   Amitava Dasgupta     41
Analytical Techniques for Measuring Concentrations of Therapeutic Drugs in Biological Fluids   Amitava Dasgupta   Pradip Datta     67
The Pre-Analytical Phase of Drug Testing: From Specimen Collection to Analysis   Catherine A. Hammett-Stabler     87
Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins, and System Factors on Therapeutic Drug Monitoring   Pradip Datta     97
Digoxin: So Many Interferences and How to Eliminate Them   Amitava Dasgupta     111
Interferences with Measurement of Anticonvulsants   William Clarke     133
Pitfalls in Measuring Antidepressant Drugs   Uttam Garg     149
Immunosuppressive Drugs: Pharmacokinetics, Preanalytic Variables, and Analytical Considerations   Anthony W. Butch     165
Therapeutic Drug Monitoring in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome   Steven J. Soldin     201
Pharmacogenomics and Personalized Medicine: Issues and Methodology   Steven H. Y. Wong     211
Interference of Heterophilic and Other Antibodies inMeasurement of Therapeutic Drugs by Immunoassays   Pradip Datta     225
Drug-Herb and Drug-Food Interactions: Impact on Therapeutic Drug Monitoring   Amitava Dasgupta     235
Toxic Element Testing with Clinical Specimens   Gwendolyn A. McMillin   Joshua A. Bornhorst     263
Alcohol Testing   Steve C. Kazmierczak   Hassan M. E. Azzazy     283
Introduction to Drugs of Abuse Testing   Tai C. Kwong     297
Urinary Adulterants and Drugs of Abuse Testing   Amitava Dasgupta     317
Hair, Oral Fluid, Sweat, and Meconium Testing for Drugs of Abuse: Advantages and Pitfalls   Uttam Garg     337
Abused and Designer Drugs and How They Escape Detection   Barry Levine   Rebecca Jufer-Phipps     365
Interpretation of Amphetamines Screening and Confirmation Testing   Larry Broussard     379
Clinical False-Positive Drug Test Results   Tai C. Kwong     395
Providing Expert Witness for Alcohol and Positive Drugs of Abuse Test Results   Andrea Terrell   William Clarke   Michael Evans   Jennifer Collins     407
Index     421
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