Handbook of Epigenetics: The New Molecular and Medical Genetics

by Trygve O. Tollefsbol (Editor)

Overview

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging.

The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.

Product Details

ISBN-13:	9780128053881
Publisher:	Elsevier Science
Publication date:	08/07/2017
Edition description:	New Edition
Pages:	682
Product dimensions:	8.50(w) x 10.88(h) x (d)

About the Author

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O'Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Table of Contents

1. Epigenetics Overview

SECTION I: Molecular Mechanisms of Epigenetics
2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development
3. Mechanisms of Histone Modification
4. The Epigenetics of Non-coding RNA
5. Prions and Prion-like Phenomena in Epigenetic Inheritance
6. Higher-order Chromatin Organization in Diseases
7. Polycomb-group Proteins and Epigenetic Control of Gene Activity

SECTION II: Methods in Epigenetics
8. Methods for Assessing DNA Cytosine Modifications Genome-wide
9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome
10. Techniques for Genome-wide Expression of Non-coding RNA
11. Computational Epigenetics

SECTION III: Model Organisms of Epigenetics
12. Epigenetics of Lower Organisms
13. Drosophila Epigenetics
14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies
15. Plant Epigenomics

SECTION IV: Factors Influencing Epigenetic Changes
16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions
17. Epigenetic Biomarkers
18. Transposable elements shaping the epigenome 
19. Metabolic Regulation of DNA Methylation in Mammalian Cells
20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications
21. Epigenetics, Stem Cells and Cellular Differentiation
22. Regeneration Epigenetics
23. Epigenetics of X-chromosome Inactivation
24. Epigenetics of Memory Processes
25. Transgenerational Epigenetics
26. DNA Methylation Clocks in Age-related Disease

SECTION V: Evolutionary Epigenetics
27. Evolution of Epigenetic Mechanisms in Plants
28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation   
29. Adaptive Evolution and Epigenetics

SECTION VI: Epigenetic Epidemiology
30. Epigenetics of Livestock Breeding
31. Nutritional Epigenetics and Metabolic Syndrome
32. Epigenetics of Drug Addiction
33. Environmental Influence of Epigenetics
34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease
35. Population Pharmacoepigenomics

SECTION VII: Epigenetics and Human Disease
36. Cancer Epigenetics
37. The Role of Epigenetics in Autoimmune Disorders
38. Epigenetics of Brain Disorders
39. The Epigenetics of Metabolic Diseases
40. Imprinting Disorders in Humans

SECTION VIII: Epigenetic Therapy
41. DNA Demethylating Agents in Clinical Medicine
42. Clinical Applications of Histone Deacetylase Inhibitors
43. Combination Epigenetic Therapy

SECTION XI: The Future of Epigenetics
44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

What People are Saying About This

From the Publisher

A complete survey of the emerging field of epigenetics, from molecular research to therapeutic applications

Editorial Reviews

"The Handbook of Epigenetics contains an impressive collection of 37 articles, mainly dealing with the biology of epigenetics. Covered topics range from molecular marks and mechanism, over model systems, epidemiology, aging and the brain to diseases…. In summary, the Handbook of Epigenetics provides a unique and useful combination of information and it is a valuable addition to the bookshelf of scientists with experience in the field." —CHEMBIOCHEM

From the Publisher