Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists / Edition 1

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists / Edition 1

by Younggil Kwon
     
 

ISBN-10: 0306462346

ISBN-13: 9780306462344

Pub. Date: 12/01/2001

Publisher: Springer US

This volume is a handbook primarily designed for scientists and technicians without formal pharmacokinetics/pharmacodynamics (PK/PD) training, who work in an industrial setting. The book is a primary desktop reference and contains easy-to-understand guidance for PK/PD issues, study design, and data interpretation. PK/PD are integral aspects for investigating the…  See more details below

Overview

This volume is a handbook primarily designed for scientists and technicians without formal pharmacokinetics/pharmacodynamics (PK/PD) training, who work in an industrial setting. The book is a primary desktop reference and contains easy-to-understand guidance for PK/PD issues, study design, and data interpretation. PK/PD are integral aspects for investigating the disposition and pharmacological efficacy of drugs under various experimental and clinical conditions

Product Details

ISBN-13:
9780306462344
Publisher:
Springer US
Publication date:
12/01/2001
Edition description:
2002
Pages:
291
Product dimensions:
6.14(w) x 9.21(h) x 0.03(d)

Table of Contents

1Introduction1
2Pharmacokinetic Study Design and Data Interpretation3
3New Approaches for High Throughput In Vivo Exposure Screening29
4Absorption35
5Distribution73
6Clearance83
7Protein Binding105
8Metabolism121
9Biliary Excretion169
10Nonlinear Pharmacokinetics175
11Pharmacodynamics and Pharmacokinetic/Pharmacodynamic Relationships189
12Predicting Pharmacokinetics in Humans207
13Animal Physiology229
Glossary241
App. AImportant Pharmacokinetic Equations273
App. BTypical Pharmacokinetic Issues and Their Potential Causes278
App. CReferences for Laboratory Animal Experiments279
App. D: Abbreviations282
Index287

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