Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists / Edition 1

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Overview

This volume is a handbook primarily designed for scientists and technicians without formal pharmacokinetics/pharmacodynamics (PK/PD) training, who work in an industrial setting. The book is a primary desktop reference and contains easy-to-understand guidance for PK/PD issues, study design, and data interpretation. PK/PD are integral aspects for investigating the disposition and pharmacological efficacy of drugs under various experimental and clinical conditions
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Editorial Reviews

From The Critics
Kwon's guide to the industrial applications of pharmacokinetics, pharmacodynamics, and drug metabolism is intended primarily for industrial scientists, lab assistants, and managers in the discovery and development groups of pharmaceutical companies. Thirteen chapters deal with specific PK/PD/DM issues; the work also covers recent topics on higher-throughput in-vivo exposure screening and the prediction of pharmacokinetics in humans. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780306462344
  • Publisher: Springer US
  • Publication date: 12/1/2001
  • Edition description: 2002
  • Edition number: 1
  • Pages: 316
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.81 (d)

Table of Contents

1 Introduction 1
2 Pharmacokinetic Study Design and Data Interpretation 3
3 New Approaches for High Throughput In Vivo Exposure Screening 29
4 Absorption 35
5 Distribution 73
6 Clearance 83
7 Protein Binding 105
8 Metabolism 121
9 Biliary Excretion 169
10 Nonlinear Pharmacokinetics 175
11 Pharmacodynamics and Pharmacokinetic/Pharmacodynamic Relationships 189
12 Predicting Pharmacokinetics in Humans 207
13 Animal Physiology 229
Glossary 241
App. A Important Pharmacokinetic Equations 273
App. B Typical Pharmacokinetic Issues and Their Potential Causes 278
App. C References for Laboratory Animal Experiments 279
App. D: Abbreviations 282
Index 287
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