Handbook of Extemporaneous Preparation: A Guide to Pharmceutical Compounding / Edition 1

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More About This Textbook

Overview

A comprehensive and easy-to-follow guide to good practice in extemporaneous compounding. It incorporates the key findings and outputs from the UK National Advisory Board study, including advice on purchasing unlicensed medicines. It will be adopted as the standard for extemporaneous dispensing for NHS patients. Although the standards set out in this book are primarily written for implementation in NHS hospitals, the principles should be equally applied across the profession internationally. Written in two parts, this book provides: standards for extemporaneous dispensing stability summaries for the 50 most commonly prepared extemporaneously prepared medicines in NHS hospitals. Compounding of pharmaceutical formulations remains a core skill of pharmacists and is taught at undergraduate level. Written by experts in the field with input from the UK NHS Pharmaceutical Quality Assurance Committee, this book will be an invaluable reference for any clinical or procurement pharmacist, pharmacy technician or student involved with extemporaneous preparation.

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Product Details

  • ISBN-13: 9780853699019
  • Publisher: Pharmaceutical Press
  • Publication date: 5/1/2010
  • Edition number: 1
  • Pages: 464
  • Sales rank: 355,717
  • Product dimensions: 6.10 (w) x 9.10 (h) x 1.10 (d)

Table of Contents

Preface viii

About the editors xi

Membership of the editorial board xiii

Acknowledgements xiv

Part A Standards 1

1 Introduction 3

2 Risk management 11

3 Quality management 23

4 Personnel and training 27

5 Premises and equipment 31

6 Documentation 35

7 Preparation 41

8 Formulation and stability 47

9 Quality control 55

10 Complaints, product recalls and adverse events 59

11 Procurement and quality assessment of extemporaneously prepared medicines 61

12 Audit and monitoring 65

Part B Extemporaneous preparation formulary 67

13 Introduction 69

14 Formulary of extemporaneous preparations 87

Acetazolamide oral liquid 89

Allopurinol oral liquid 96

Amiodarone hydrochloride oral liquid 103

L-Arginine hydrochloride oral liquid 110

Azathioprine oral liquid 113

Bendroflumethiazide oral liquid 120

Captopril oral liquid 125

Clobazam oral liquid 134

Clonazepam oral liquid 138

Clonidine hydrochloride oral liquid 144

Clozapine oral liquid 150

Co-careldopa oral liquid (levodopa and carbidopa) 158

Co-enzyme Q10 oral liquid 166

Dexamethasone oral liquid and dexamethasone sodium phosphate oral liquid 171

Diazoxide oral liquid 178

Dinoprostone (prostaglandin E2) oral liquid 183

Ergocalciferol oral liquid 189

Ethambutol hydrochloride oral liquid 194

Gabapentin oral liquid 200

Gliclazide oral liquid 205

Hydrocortisone oral liquid 209

Indometacin (indomethacin) oral liquid 217

Isosorbide mononitrate oral liquid 227

Joulie's solution (oral phosphate supplement) 231

Knox mouthwash 237

Levothyroxine sodium oral liquid 243

Lorazepam oral liquid 255

Magnesium glycerophosphate oral liquid 264

Menadiol sodium phosphate oral liquid 268

Metformin hydrochloride oral liquid 272

Midazolam hydrochloride oral liquid 276

Morphine sulfate oral liquid 288

Omeprazole oral liquid 300

Phenobarbital and phenobarbital sodium oral liquid 315

Phenoxybenzamine hydrochloride oral liquid 329

Potassium acid phosphate oral liquid 336

Primidone oral liquid 339

Pyrazinamide oral liquid 344

Pyridoxine hydrochloride (vitamin B6) oral liquid 351

Quinine sulfate oral liquid 357

Sildenafil citrate oral liquid 363

Sodium bicarbonate oral liquid 368

Sodium chloride oral solution 373

Sodium phenylbutyrate oral liquid 377

St Mark's solution 380

Tacrolimus oral mouthwash 383

Tacrolimus oral suspension 387

Thiamine hydrochloride oral liquid 396

Tranexamic acid oral mouthwash 404

Vancomycin hydrochloride oral liquid 408

Warfarin sodium oral liquid 417

Appendix 1 Change control request form 425

Appendix 2 Deviation reporting form 427

Appendix 3 Example raw material specification 429

Appendix 4 Example worksheet 431

Appendix 5 Technical agreement for commissioning of extemporaneous product preparation service 433

Appendix 6 Audit tool for extemporaneous preparation 437

Appendix 7 Suspending agents 445

Glossary 447

Index 449

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