Handbook of Hypertension / Edition 1

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Save precious time and improve patient care by consulting this impartial, evidence-based guide to hypertension and associated disease.

Handbook of Hypertension gives you fast access to specific information on the vast array of available drugs so you can identify the most appropriate medication and use it as part of an integrated care plan. Tables, figures, charts, and summaries of principal findings from clinical studies on hypertension put vital information within reach.

After a through introduction to hypertension, the book addresses

What is Hypertension

Treatment of Hypertension

Associated Problems with Hypertension The Clinical Trials of Hypertension

Special Considerations in the Management of Hypertension Based on the Hypertension Clinical Trials

A final section on The Antihypertensive Drugs provides a comprehensive and current review of all antihypertensive drug classes. Dr. Houston draws on his years of practice to offer sensible advice on the relative merits of the many drug classes, from diuretics and beta-blockers to selected combination antihypertensive drugs and new antihypertensive drug classes.

The perfect blend of evidence and experience, Handbook of Hypertension should be in close reach for frequent consultations by every clinician who treats patients with high blood pressure.

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Product Details

  • ISBN-13: 9781405182508
  • Publisher: Wiley
  • Publication date: 5/5/2009
  • Edition number: 1
  • Pages: 412
  • Product dimensions: 5.50 (w) x 8.40 (h) x 1.00 (d)

Meet the Author

Mark C. Houston, MD, MSc, FACP, FAHA
Associate Clinical Professor of Medicine
Vanderbilt University School of Medicine
ASH Specialist in Clinical Hypertension
Director, Hypertension Institute and Vascular Biology, Nashville, Tennessee
Section Chief, Division of Nutrition and Clinical Research
Staff Physician, Vascular Institute
Saint Thomas Hospital
Nashville, Tennessee
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Table of Contents

Abbreviations ix

Part 1 General Introduction to Hypertension

Hypertension Prevalence and Consequences 3

Hypertension Syndrome 4

Subsets of Hypertension Approach to Treatment 5

Clinical Hypertension Trials: A Perspective 6

Vascular Biology and Hypertension 8

Blood Vessel Structure 11

Endothelial Function and Dysfunction 12

New Treatment Approach to Hypertension Based on Concepts of Endothelial Dysfunction and Vascular Biology 14

Treatment of Impaired Endothelial Function: A Global CV Approach 16

Part 2 What is Hypertension

Hypothesis: Essential Hypertension and End-Organ Damage 19

Hypertension Classification and Guidelines Worldwide 21

Hypertension Guidelines 24

Global CV Risk Calculation 41

Secondary Hypertension 50

BP Measurement 52

Hypertension-Atherosclerotic Syndrome 54

Normotensive Hypertension and Hypertension Syndromes 57

Prehypertension 58

Part 3 Treatment of Hypertension

Nonpharmacologic Treatment of Hypertension 61

Nutrition, Vitamins, Minerals, Antioxidants, Dietary, and Nutraceutical Supplements in the Prevention and Treatment of Hypertension 63

Nutritional Intervention, Prevention, and Treatment of Hypertension Trials and Consensus Reports 71

Further Reading on Nutrition and Dietary Supplements 72

The DASH Diets: DASH-I and DASH-II Sodium 75

The Premier Clinical Trial 78

Obesity 80

Exercise Activities and Kilocalories Used 81

Approaches to Selection of Antihypertensive Therapy 82

Hemodynamics in Hypertension 83

Hemodynamic Effects of Antihypertensive Drugs 85

Part 4 Problems Associated with Hypertension

Hypertension-Related End-Organ Damage 89

Life Expectancy and Blood Pressure (Man, 35Years Old) 90

Systolic, Diastolic, and Pulse Pressure Concepts 91

Part 5 The Clinical Trials of Hypertension

Clinical Hypertension Trials and Antihypertensive Drug Therapy 97

Treatment of Hypertension: Questions Posed 106

Clinical Hypertension Trials: Important Clinical Points 107

Diuretic/BB Clinical Trials in Mild-to-Moderate Hypertension and CHD: Summary 110

Meta-Analysis of Randomized Controlled Clinical Hypertension Trials with Antihypertensive Drug Therapy 112

Meta-Analysis by BP Lowering Treatment Trialists Collaboration 131

Staessen, Wang, and This Meta-Analysis: Summary of Clinical Trials in Hypertension and Clinical Outcomes 132

Further Reading: Health Outcomes Analysis for Clinical Hypertension Trials 133

Combination Meta-Analysis of 354 Randomized Trials 139

Prospective Clinical Trials in Hypertension Comparing CCBs to Other Antihypertensive Therapy: Total of 29 Trials 140

Clinical Hypertension Trials with CCBs 141

SYST-EUR Results 143

Conclusions of SYST-EUR Study 144

SYST-CHINA Results 146

HOT Trial 2 Results 147

Results 148

Insight 149

Nordil 151

Convince 153

Prevent 156

Vhas 157

Pate 158

Incidence of Fatal and Nonfatal CV Events 159

Allhat 160

Stop-2 170

Idnt 173

Aask 174

Abcd 175

Elsa 176

Invest 177

Shell 178

Midas 179

Glant 180

Facet 181

Action 182

Ascot Clinical Trials: LLA, BPLA, and LLA 2 x 2 183

Ascot LLA 188

Ascot BPLA 189

Ascot LLA 2 x 2 190

Value 191

Benedict 192

Phyllis 195

Quiet 196

Scat 197

Advance 198

Protect 199

Anbp-2 200

Diab-Hycar 201

Europa 202

HDS 203

Hyvet 204

Part-2 205

Peace 206

Cappp 207

Hope (Heart Outcomes Prevention Evalution Study) 209

Progress 211

Valsartan Antihypertension Long-Term Use Evaluation Trial (Value) 219

Clinical Hypertension Trials in Hypertension with ARBs: Summary 222

Scope 223

Part 6 Special Considerations in the Management of Hypertension Based on the Hypertension Clinical Trials

CHD Risk Factor and Effects of Antihypertensive Drug Therapy 227

CHD: More Potential Risk Factors 228

CHD Risk Factors: Influence of Diuretic and BB Therapy 230

Antihypertensive Drugs and CHD Risk Factors: Summary 236

Hypertension and Renal Disease 238

DM and Hypertension Summary 250

Selection of Therapy Based on Subsets of Hypertension 275

Demographics and Antihypertensive Drugs 281

Resistant Hypertension 282

ISH in the Elderly 284

Hypertensive Urgencies and Emergencies 286

Hypertensive in Pregnancy 291

Part 7 The Antihypertensive Drugs

General Review of Antihypertensive Drug Classes 295

Specific Review of All Antihypertensive Drug Classes 302

Arterial Compliance: Structure/Function: Treatment Considerations 365

Selected Combination Antihypertensive Drugs 366

Hypertension Drug Selection: Summary 368

Subset Selection of Antihypertensive Therapy 371

Conclusions 373

References 375

Index 393

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