A Handbook of Mouse Models of Cardiovascular Disease / Edition 1

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The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories.

A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model.

A Handbook of Mouse Models of Cardiovascular Disease:

  • Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis
  • Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure
  • Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems
  • Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology

This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

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Product Details

  • ISBN-13: 9780470016107
  • Publisher: Wiley
  • Publication date: 8/18/2006
  • Edition number: 1
  • Pages: 402
  • Product dimensions: 6.91 (w) x 9.90 (h) x 1.22 (d)

Meet the Author

Qingbo Xu. John Parker Professor of Vascular Biology,Department of Cardiac and Vascular Sciences, St George's HospitalMedical School.

Professor Xu has an excellent standing in the field ofatherosclerosis with an outstanding scientific track record. He ispart of a European Network of Excellence on vascular biology, whichis a large consortium of experts. He is an expert in mouse modelsand in microsurgery. His group pioneers the study of heat shockproteins in atherogenesis and has established the first mouse modelof vein graft atherosclerosis, which is proven to be powerful instudying the mechanisms of progenitor cells participating inatherosclerosis. Professor Xu’s group also generated thefirst PKC knockout mice and analysed protein profiles ofcardiovascular cells in these mice.

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Table of Contents



1 general information (Hermann Dietrich).

2 Naturally occurring variation among mouse strains(Weibin Shi and Aldons J. Lusis).

3 Transgenic and Gene-targeted Mice of Hyperlipidemia(Yadong Huang).

4 Bone Marrow Transplantation: the methodology and itsapplication in atherosclerosis research Menno (P.J. deWinter and Marten H. Hofker Introduction).

5 Hyperlipidemia-induced Atherosclerosis (AlanDaugherty and Debra L. Rateri).

6 Magnetic Resonance Imaging Evaluation of AtheroscleroticPlaque (Martina A McAteer, Jurgen E. Schneider and Robin P.Choudhury).

7 Plaque Rupture (Christopher Jackson).

8 Perivascular Cuff-, Electronic- and Chemical Injury-inducedStenosis Nuno (M.M. Pires, Margreet R. de Vries, AbbeySchepers, Daniel Eefting, Jan-Willem H.P. Lardenoye and Paul H.A.Quax).

9 Flow-induced Vascular Remodeling (Vycheslav A.Korshunov and Bradford C. Berk).

10 Vein Graft Atherosclerosis (Yanhua Hu and QingboXu).

11 Angiotensin II-induced aortic aneurysms (Yi-XinWang, Lisa A. Cassis and Alan Daugherty).

12 Carotidojugular Fistula (Yves Castier, Alain Tedguiand Stéphanie Lehoux).

13 Applications to the Study of Stroke (Jaques Seylazand Elisabeth Pinard).

14 Identifying Congenital Heart Defects in Embryos UsingHigh-resolution Magnetic Resonance Imaging (Jürgen E.Schneider and Shoumo Bhattacharya).

15 Allograft Arteriopathy: Heterotopic Heart Transplantationand Aortic Interposition Grafts (Koichi Shimizu and RichardN. Mitchell).

16 Heart Preconditioning Analysis (Guang-Wu Wang,David A. Liem, Steven Le and Peipei Ping).

17 Myocardial Ischemia–Reperfusion (BernhardMetzler, Elisabetta Conci and Omar Pachinger).

18 Cardiac Hypertrophy (David J. Grieve, Alison C.Cave and Ajay M. Shah).

19 The Retrogradely Perfused Isolated Heart Model(Mihaela M. Mocanu and Derek M. Yellon).

20 Measurement of Pulse Wave Velocity (Yi-XinWang).

21 Gene Transfer to Dyslipidemic Mice (Kazuhiro Oka,Andrew H. Baker and Lawrence Chan).

22 Hypertension (Daiana Weiss and W. RobertTaylor).

23 Ischemia-induced Neovascularisation (Ken-ichiroSasaki, Christopher Heeschen, Alexandra Aicher and StefanieDimmeler).

24 Angiogenesis in Biomatrices and Artificial Materials(Pieter Koolwijk and Victor W.M. van Hinsburgh).

25 Venous Thrombosis (Alberto Smith, James Gossage andBijan Moderai).

26 Virus-induced Vasculitis (Phillippe Krebs andBurkhard Ludewig).

27 Surgically induced Chronic Heart Failure (Craig A.Lygate and Stefan Neubauer).

28 Atrial Fibrillation (Sander Verheule, Toshiako Satoand Jeffrey E. Olgin).

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