A Handbook of Mouse Models of Cardiovascular Disease / Edition 1

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The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories.

A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model.

A Handbook of Mouse Models of Cardiovascular Disease:

  • Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis
  • Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure
  • Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems
  • Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology

This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

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Product Details

  • ISBN-13: 9780470016107
  • Publisher: Wiley
  • Publication date: 8/18/2006
  • Edition number: 1
  • Pages: 402
  • Product dimensions: 6.91 (w) x 9.90 (h) x 1.22 (d)

Meet the Author

Qingbo Xu. John Parker Professor of Vascular Biology, Department of Cardiac and Vascular Sciences, St George's Hospital Medical School.

Professor Xu has an excellent standing in the field of atherosclerosis with an outstanding scientific track record. He is part of a European Network of Excellence on vascular biology, which is a large consortium of experts. He is an expert in mouse models and in microsurgery. His group pioneers the study of heat shock proteins in atherogenesis and has established the first mouse model of vein graft atherosclerosis, which is proven to be powerful in studying the mechanisms of progenitor cells participating in atherosclerosis. Professor Xu’s group also generated the first PKC knockout mice and analysed protein profiles of cardiovascular cells in these mice.

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Table of Contents



1 general information (Hermann Dietrich).

2 Naturally occurring variation among mouse strains (Weibin Shi and Aldons J. Lusis).

3 Transgenic and Gene-targeted Mice of Hyperlipidemia (Yadong Huang).

4 Bone Marrow Transplantation: the methodology and its application in atherosclerosis research Menno (P.J. de Winter and Marten H. Hofker Introduction).

5 Hyperlipidemia-induced Atherosclerosis (Alan Daugherty and Debra L. Rateri).

6 Magnetic Resonance Imaging Evaluation of Atherosclerotic Plaque (Martina A McAteer, Jurgen E. Schneider and Robin P. Choudhury).

7 Plaque Rupture (Christopher Jackson).

8 Perivascular Cuff-, Electronic- and Chemical Injury-induced Stenosis Nuno (M.M. Pires, Margreet R. de Vries, Abbey Schepers, Daniel Eefting, Jan-Willem H.P. Lardenoye and Paul H.A. Quax).

9 Flow-induced Vascular Remodeling (Vycheslav A. Korshunov and Bradford C. Berk).

10 Vein Graft Atherosclerosis (Yanhua Hu and Qingbo Xu).

11 Angiotensin II-induced aortic aneurysms (Yi-Xin Wang, Lisa A. Cassis and Alan Daugherty).

12 Carotidojugular Fistula (Yves Castier, Alain Tedgui and Stéphanie Lehoux).

13 Applications to the Study of Stroke (Jaques Seylaz and Elisabeth Pinard).

14 Identifying Congenital Heart Defects in Embryos Using High-resolution Magnetic Resonance Imaging (Jürgen E. Schneider and Shoumo Bhattacharya).

15 Allograft Arteriopathy: Heterotopic Heart Transplantation and Aortic Interposition Grafts (Koichi Shimizu and Richard N. Mitchell).

16 Heart Preconditioning Analysis (Guang-Wu Wang, David A. Liem, Steven Le and Peipei Ping).

17 Myocardial Ischemia–Reperfusion (Bernhard Metzler, Elisabetta Conci and Omar Pachinger).

18 Cardiac Hypertrophy (David J. Grieve, Alison C. Cave and Ajay M. Shah).

19 The Retrogradely Perfused Isolated Heart Model (Mihaela M. Mocanu and Derek M. Yellon).

20 Measurement of Pulse Wave Velocity (Yi-Xin Wang).

21 Gene Transfer to Dyslipidemic Mice (Kazuhiro Oka, Andrew H. Baker and Lawrence Chan).

22 Hypertension (Daiana Weiss and W. Robert Taylor).

23 Ischemia-induced Neovascularisation (Ken-ichiro Sasaki, Christopher Heeschen, Alexandra Aicher and Stefanie Dimmeler).

24 Angiogenesis in Biomatrices and Artificial Materials (Pieter Koolwijk and Victor W.M. van Hinsburgh).

25 Venous Thrombosis (Alberto Smith, James Gossage and Bijan Moderai).

26 Virus-induced Vasculitis (Phillippe Krebs and Burkhard Ludewig).

27 Surgically induced Chronic Heart Failure (Craig A. Lygate and Stefan Neubauer).

28 Atrial Fibrillation (Sander Verheule, Toshiako Sato and Jeffrey E. Olgin).

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