A Handbook of Mouse Models of Cardiovascular Disease / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $194.76
Usually ships in 1-2 business days
(Save 24%)
Other sellers (Hardcover)
  • All (7) from $194.76   
  • New (6) from $194.76   
  • Used (1) from $243.80   

Overview

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories.

A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model.

A Handbook of Mouse Models of Cardiovascular Disease:

  • Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis
  • Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure
  • Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems
  • Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology

This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

Read More Show Less

Product Details

  • ISBN-13: 9780470016107
  • Publisher: Wiley
  • Publication date: 8/18/2006
  • Edition number: 1
  • Pages: 402
  • Product dimensions: 6.91 (w) x 9.90 (h) x 1.22 (d)

Meet the Author

Qingbo Xu. John Parker Professor of Vascular Biology,Department of Cardiac and Vascular Sciences, St George's HospitalMedical School.

Professor Xu has an excellent standing in the field ofatherosclerosis with an outstanding scientific track record. He ispart of a European Network of Excellence on vascular biology, whichis a large consortium of experts. He is an expert in mouse modelsand in microsurgery. His group pioneers the study of heat shockproteins in atherogenesis and has established the first mouse modelof vein graft atherosclerosis, which is proven to be powerful instudying the mechanisms of progenitor cells participating inatherosclerosis. Professor Xu’s group also generated thefirst PKC knockout mice and analysed protein profiles ofcardiovascular cells in these mice.

Read More Show Less

Table of Contents

Contributors.

Preface.

1 general information (Hermann Dietrich).

2 Naturally occurring variation among mouse strains(Weibin Shi and Aldons J. Lusis).

3 Transgenic and Gene-targeted Mice of Hyperlipidemia(Yadong Huang).

4 Bone Marrow Transplantation: the methodology and itsapplication in atherosclerosis research Menno (P.J. deWinter and Marten H. Hofker Introduction).

5 Hyperlipidemia-induced Atherosclerosis (AlanDaugherty and Debra L. Rateri).

6 Magnetic Resonance Imaging Evaluation of AtheroscleroticPlaque (Martina A McAteer, Jurgen E. Schneider and Robin P.Choudhury).

7 Plaque Rupture (Christopher Jackson).

8 Perivascular Cuff-, Electronic- and Chemical Injury-inducedStenosis Nuno (M.M. Pires, Margreet R. de Vries, AbbeySchepers, Daniel Eefting, Jan-Willem H.P. Lardenoye and Paul H.A.Quax).

9 Flow-induced Vascular Remodeling (Vycheslav A.Korshunov and Bradford C. Berk).

10 Vein Graft Atherosclerosis (Yanhua Hu and QingboXu).

11 Angiotensin II-induced aortic aneurysms (Yi-XinWang, Lisa A. Cassis and Alan Daugherty).

12 Carotidojugular Fistula (Yves Castier, Alain Tedguiand Stéphanie Lehoux).

13 Applications to the Study of Stroke (Jaques Seylazand Elisabeth Pinard).

14 Identifying Congenital Heart Defects in Embryos UsingHigh-resolution Magnetic Resonance Imaging (Jürgen E.Schneider and Shoumo Bhattacharya).

15 Allograft Arteriopathy: Heterotopic Heart Transplantationand Aortic Interposition Grafts (Koichi Shimizu and RichardN. Mitchell).

16 Heart Preconditioning Analysis (Guang-Wu Wang,David A. Liem, Steven Le and Peipei Ping).

17 Myocardial Ischemia–Reperfusion (BernhardMetzler, Elisabetta Conci and Omar Pachinger).

18 Cardiac Hypertrophy (David J. Grieve, Alison C.Cave and Ajay M. Shah).

19 The Retrogradely Perfused Isolated Heart Model(Mihaela M. Mocanu and Derek M. Yellon).

20 Measurement of Pulse Wave Velocity (Yi-XinWang).

21 Gene Transfer to Dyslipidemic Mice (Kazuhiro Oka,Andrew H. Baker and Lawrence Chan).

22 Hypertension (Daiana Weiss and W. RobertTaylor).

23 Ischemia-induced Neovascularisation (Ken-ichiroSasaki, Christopher Heeschen, Alexandra Aicher and StefanieDimmeler).

24 Angiogenesis in Biomatrices and Artificial Materials(Pieter Koolwijk and Victor W.M. van Hinsburgh).

25 Venous Thrombosis (Alberto Smith, James Gossage andBijan Moderai).

26 Virus-induced Vasculitis (Phillippe Krebs andBurkhard Ludewig).

27 Surgically induced Chronic Heart Failure (Craig A.Lygate and Stefan Neubauer).

28 Atrial Fibrillation (Sander Verheule, Toshiako Satoand Jeffrey E. Olgin).

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)