Handbook of Nanoindentation: With Biological Applications

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Nanoindentation is ideal for the characterization of inhomogeneous biological materials, but its use in biological systems is associated with some distinct challenges. For example, engineering materials used in the microelectronics industry (e.g., ceramics and metals) are relatively stiff and exhibit time-independent mechanical responses, whereas biological materials exhibit time-dependent behavior and can span a range of stiffness regimes. Therefore, there are differences in the selection of instrumentation, tip geometry, and data analysis in comparison with the "black box" nanoindentation techniques as sold by commercial manufacturers. The use of scanning probe equipment (atomic force microscopy) is also common for small-scale indentation of soft materials in biology.

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Product Details

  • ISBN-13: 9789814241892
  • Publisher: Taylor & Francis
  • Publication date: 11/1/2010
  • Pages: 358
  • Product dimensions: 6.70 (w) x 9.80 (h) x 0.90 (d)

Meet the Author

Michelle L. Oyen is a Lecturer in Mechanics of Biological Materials in the Mechanics and Materials Division and the Engineering for the Life Sciences group in the Cambridge University Engineering Department. She holds a BS degree in Materials Science and Engineering and an MS Degree in Engineering Mechanics, both from Michigan State University, and a PhD degree in Biophysical Sciences and Medical Physics from the University of Minnesota. She joined Cambridge Engineering in 2006 following an appointment as Research Scientist at the University of Virginia Center for Applied Biomechanics. She is a member of the Materials Research Society and the ASME Bioengineering Division, a principal editor for the Journal of Materials Research, a moderator of iMechanica and a founding committee member for the new UK-based bioengineering society.

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Table of Contents

Preface v

Chapter 1 Introduction Tamaryn A. V. Shean Michelle L. Oyen Michael F. Ashby 1

Chapter 2 Indentation and Adhesion at Small Length Scales Robert F. Cook 23

Chapter 3 Instrumentation and Experimentation Kryslyn J. Van Vliet 39

Chapter 4 Mechanics of Adhesion Robert F. Cook 77

Chapter 5 Mechanics of Indentation Michelle L. Oyen 123

Chapter 6 Computational Modeling of Indentation Xi Chen 153

Chapter 7 Nanoindentation of Bone Virginia L. Ferguson Sara E. Olesiak 185

Chapter 8 Nanoindentation of Tooth Tissues Li-Hong He Michael V. Swain 239

Chapter 9 Nanoindentation of Soft Tissues and Other Biological Materials Donna M. Ebenstein 279

Chapter 10 Cells and Membranes Kuo-Kang Liu Kai-Tak Wan 325

Chapter 11 Conclusions and Outlook Michelle L. Oyen 351

Index 357

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