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Doody's Review ServiceReviewer: Dara W. Frank, PhD (Medical College of Wisconsin)
Description: This is the latest in a series of books describing the structure, function, and biogenesis of bacterial toxins with ADP-ribosyltransferase activity. The comparison of several toxin crystal structures has lead to new insights that are summarized in well-documented detail.
Purpose: The purpose is to provide detailed and up-to-date information of the structure and function of toxins relative to bacterial pathogenesis and virulence. This important and timely review summarizes in concise and well-illustrated chapters the molecular mechanisms involved in binding, entry, and intoxication of eukaryotic cells.
Audience: The book is intended as a comprehensive review for students and scientists involved in studying eukaryotic cellular signaling and metabolism, bacterial pathogenesis, protein structure and function, and ADP-ribosylating enzymes.
Features: Important features include several illustrations of toxin structure, tables comparing and aligning protein sequences, and models for catalysis and intoxication. This gives the reader an up-to-date perspective on domain structure and its relevance to cellular toxicity.
Assessment: This useful collection of chapters summarizes the most current information about an important family of bacterial proteins. The emphasis on structure and function provides a good framework for students and scientists interested in cell biology, bacterial pathogenesis, protein translocation, and the therapeutic uses of toxic molecules.