Handbook of Pharmacogenomics and Stratified Medicine by Elsevier Science | Hardcover | Barnes & Noble
Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine

by Elsevier Science
     
 

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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand the rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The

Overview

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand the rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To cater to the widest range of readers, the clinical application section introduces the disease process, the existing therapies and explains the pharmacogenomic aspects against this background.

Medicine isthe cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and identifying the genetic basis of disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

  • Provides clinical and non-clinical researchers with practical information normally beyond their areas of research or expertise
  • Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics
  • Covers newer technologies- next generation sequencing, proteomics, metabolomics
  • Provides information on animal models, lymphoblastoid cell lines, stem cells
  • Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues
  • Includes chapters on the global implications of pharmacogenomics

Editorial Reviews

Doody's Review Service
Reviewer: Rachel R Chennault, PhD (American College of Clinical Pharmacy)
Description: Innovation in the field of pharmacogenomics over the last decade has spanned the entire spectrum of medicine. This is a comprehensive review of the basic scientific principles that drive innovation in this rapidly progressing field, and the implementation of these principles in the development and clinical use of strategically-tailored therapeutic approaches.
Purpose: Due to the influx of pharmacogenetic information into the drug development process and its expanding application in clinical practice, the purpose of this book is met, serving as an accessible resource describing the founding principles and disease domains specifically impacted by pharmacogenomics discoveries.
Audience: This handbook is intended for a broad audience from clinical and nonclinical backgrounds, including those in basic science, pharmacology, clinical trials, industry, and clinical practice. The chapters are authored by highly qualified experts in their fields and address all aspects of the achievements, setbacks, and remaining challenges in the field.
Features: The 46 chapters are divided into distinct domains that begin with an in-depth and comprehensive review of basic genetics, experimental animal and cell models, state-of-the-art discovery platforms, and bioinformatics. The authors next focus attention on fundamental pharmacogenomics and clinical trials and end with the application of pharmacogenomics principles in modern therapeutics, the regulatory environment, and across the globe. Each section devoted to practical clinical examples starts by explaining a disease's background and epidemiology before addressing the impact of pharmacogenomics on the disease.
Assessment: This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. Although readers may find similar concepts and alternative disease domains covered in other books, such as Principles of Pharmacogenetics and Pharmacogenomics, Altman et al. (Cambridge University Press, 2012), this handbook offers more depth in its review of the underpinning science and gives unique and careful consideration to the global implications of pharmacogenomics.
From the Publisher

"…a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time."--Anticancer Research, January 2015

"This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. - Rating: 5 Stars"--Doody's.com, 03-Oct-14

Product Details

ISBN-13:
9780123868824
Publisher:
Elsevier Science
Publication date:
05/20/2014
Pages:
1118
Product dimensions:
8.80(w) x 11.00(h) x 2.20(d)

Meet the Author

Dr Sandosh Padmanabhan is a Reader and Honorary Consultant Physician at the Institute of Cardiovascular and Medical Sciences, University of Glasgow. His research spans the genetics of cardiovascular traits, pharmacogenomics and stratified medicines and hypertension epidemiology.

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