Description: Innovation in the field of pharmacogenomics over the last decade has spanned the entire spectrum of medicine. This is a comprehensive review of the basic scientific principles that drive innovation in this rapidly progressing field, and the implementation of these principles in the development and clinical use of strategically-tailored therapeutic approaches.
Purpose: Due to the influx of pharmacogenetic information into the drug development process and its expanding application in clinical practice, the purpose of this book is met, serving as an accessible resource describing the founding principles and disease domains specifically impacted by pharmacogenomics discoveries.
Audience: This handbook is intended for a broad audience from clinical and nonclinical backgrounds, including those in basic science, pharmacology, clinical trials, industry, and clinical practice. The chapters are authored by highly qualified experts in their fields and address all aspects of the achievements, setbacks, and remaining challenges in the field.
Features: The 46 chapters are divided into distinct domains that begin with an in-depth and comprehensive review of basic genetics, experimental animal and cell models, state-of-the-art discovery platforms, and bioinformatics. The authors next focus attention on fundamental pharmacogenomics and clinical trials and end with the application of pharmacogenomics principles in modern therapeutics, the regulatory environment, and across the globe. Each section devoted to practical clinical examples starts by explaining a disease's background and epidemiology before addressing the impact of pharmacogenomics on the disease.
Assessment: This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. Although readers may find similar concepts and alternative disease domains covered in other books, such as Principles of Pharmacogenetics and Pharmacogenomics, Altman et al. (Cambridge University Press, 2012), this handbook offers more depth in its review of the underpinning science and gives unique and careful consideration to the global implications of pharmacogenomics.