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Handbook of Synthetic Antioxidants / Edition 1

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Overview

Emphasizes the efficacy of synthetically occurring compounds in the management of free radical-mediated illnesses. The text details the design, development and delivery of therapeutic antioxidants used in the treatment of pathophysiological disorders, from amylotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) to Alzheimer's disease.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Papasani V. Subbaiah, PhD (Rush University Medical Center)
Description: This multiauthored book presents the rationale behind the use of various synthetic antioxidants in preventive medicine. It provides the structures and properties of various antioxidants presently under investigation. The book has sufficiently up-to-date information and is well organized into subsections for easy reference.
Purpose: The purpose is to summarize the available information on synthetic antioxidants that are presently in use in experimental conditions.
Audience: The primary audience are scientists working in the antioxidant field. These include chemists, biochemists, and pharmacologists working in academic institutions and pharmaceutical industry. Other potential readers are investigators in food science, nutritionists, and pathologists.
Features: The book features up-to-date articles by experts in antioxidant field. It provides chemical structures, physicochemical properties, and biological effects of various antioxidants designed for specific functions.
Assessment: I found the background material provided in most articles quite useful. The compilation of articles on chemically and pharmacologically unrelated compounds in one volume is especially useful for scientists working in their respective specialized fields. The potential use of the described compounds in preventive medicine makes the book timely and useful for clinical investigators as well.
Papasani V. Subbaiah
This multiauthored book presents the rationale behind the use of various synthetic antioxidants in preventive medicine. It provides the structures and properties of various antioxidants presently under investigation. The book has sufficiently up-to-date information and is well organized into subsections for easy reference. The purpose is to summarize the available information on synthetic antioxidants that are presently in use in experimental conditions. The primary audience are scientists working in the antioxidant field. These include chemists, biochemists, and pharmacologists working in academic institutions and pharmaceutical industry. Other potential readers are investigators in food science, nutritionists, and pathologists. The book features up-to-date articles by experts in antioxidant field. It provides chemical structures, physicochemical properties, and biological effects of various antioxidants designed for specific functions. I found the background material provided in most articles quite useful. The compilation of articles on chemically and pharmacologically unrelated compounds in one volume is especially useful for scientists working in their respective specialized fields. The potential use of the described compounds in preventive medicine makes the book timely and useful for clinical investigators as well.
Booknews
Covers chemical, biological, medical, and industrial aspects of synthetic antioxidants. Contains sections on general concepts, synthetic derivatives of natural antioxidants, phenolic antioxidants, 21-aminosteroids or lazaroids, sulfhydryl- and selenium-containing, nitrones and nitroxides, SOD mimics, and metal chelators, surveying physicochemical properties of compounds and their applications in clinical medicine and the food industry. Of interest to pharmacologists, physiologists, biochemists, and cell biologists. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824798109
  • Publisher: CRC Press
  • Publication date: 2/14/1997
  • Series: Antioxidants in Health and Disease Series , #3
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 464
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.25 (d)

Table of Contents

General concepts: approach and rationale for the design of synthetic derivatives of natural antioxidants as therapeutic agents. Synthetic derivatives of natural antioxidants: design and biological evaluation of tissue-directed alpha-tocopherol analogs; physical and chemical mechanisms of the antioxidant action of tirilazad mesylate; anionic tocopherol esters as antioxidants and cytoprotectants. Phenolic antioxidants: phenolic antioxidants - physiological and toxicological aspects; antioxidant properties of probucol; antioxidant properties of the catechol derivative nitecapone. Twenty-one aminosteroids or lazaroids: neuroprotective efficacy and mechanisms of the lazaroids. Sulfhydryl and selenium-containing compounds: antioxidant properties of ebselen; the development of diaryl chalcogenides and alpha-(phenylselenenyl) ketones with antioxidant and glutathione peroxidase-mimetic properties; modulation of glutathione. Nitrones and nitroxides: nitrones radical traps as protectors of oxidative damage in the central nervous system; antioxidant properties of nitroxides and nitroxide SOD mimics. SOD mimics: mimics of superoxide dismutase. Metal chelators: antioxidant properties of synthetic iron chelators.

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