Handbook of the Aging Brain

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Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes...
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1998-08-04 Hardcover Very Good Clean copy. No marks or writing in it. Minor edge or corner wear. Every purchase will benefit global literacy. Expedited shipping recommended. ... Every purchase will benefit global literacy. Read more Show Less

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Overview

Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

Audience: Academics and researchers in gerontology, neurology, neuropsychology, cognitive psychology, psycholinguistics, neuroscience, and cell biology.

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Editorial Reviews

Doody's Review Service
Reviewer: Sean D. Ruland, DO (University of Illinois at Chicago College of Medicine)
Description: This is a relatively brief review of recent advances in the structural and neurochemical changes that occur in both normal aging and neurodegenerative processes.
Purpose: According to the editors, the purpose is to "exchange findings, discuss ideas, and assess what is currently known of the aging brain." I question, however, the need for this book, although I am writing this review from a clinician's perspective. Objectively speaking, the contributors do manage to voice their objectives despite this volume's lack of practical usefulness.
Audience: The stated evidence is quite vague, but appropriate, targeting anyone interested in this subject matter. I agree, since it cannot be stated that this is written for a specific audience such as the clinician, scientist, student, or post-graduate student.
Features: This is a review of neuroscience data, both human and animal, pertaining to neurodegeneration, both normal and pathologic. Much of the ideas provoked by this data are highly theoretical and have limited clinical application at this time. This book updates the reader on how far research has come and by no means underestimates how far we still have to go. Specific topics discussed (beyond normal aging) include, obviously, Alzheimer's disease, Parkinson's disease, and prion disease. This work probably raises more questions than provides answers. Visual aids are somewhat sparse and rather bland — perhaps consistent with the content.
Assessment: I realize this review has been critical of the lack of clinical usefulness of this book, but I cannot say that no one should read this work. It will not change the way medicine is practiced, but for those interested in the roots of the science that leads to clinical changes, this book may be of interest.
From the Publisher
"Brain structure and cognitive function in normal aging as well as in Alzheimer's disease is the focus of an excellent multi-authored volume, Handbook of the Aging Brain. An enormous amount of data is summarized leading to the overall conclusion that Alzheimer's disease is not simply a more serious or rapid extension of the normal aging process...[Handbook of the Aging Brain] is strongly recommended for those with considerable knowledge of neurobiology, Alzheimer's disease, aging, and brain disorders."
--CONTEMPORARY PSYCHOLOGY

"In conclusion, the book is a collection of reviews that offers the most recent advances in the field, and the cahpters are well-written, well-organized, and well-referenced. The book is a very good source for both clinicians and research workers."
--JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Sean D. Ruland
This is a relatively brief review of recent advances in the structural and neurochemical changes that occur in both normal aging and neurodegenerative processes. "According to the editors, the purpose is to exchange findings, discuss ideas, and assess what is currently known of the aging brain. I question, however, the need for this book, although I am writing this review from a clinician's perspective. Objectively speaking, the contributors do manage to voice their objectives despite this volume's lack of practical usefulness. "The stated evidence is quite vague, but appropriate, targeting anyone interested in this subject matter. I agree, since it cannot be stated that this is written for a specific audience such as the clinician, scientist, student, or post-graduate student. "This is a review of neuroscience data, both human and animal, pertaining to neurodegeneration, both normal and pathologic. Much of the ideas provoked by this data are highly theoretical and have limited clinical application at this time. This book updates the reader on how far research has come and by no means underestimates how far we still have to go. Specific topics discussed (beyond normal aging) include, obviously, Alzheimer's disease, Parkinson's disease, and prion disease. This work probably raises more questions than provides answers. Visual aids are somewhat sparse and rather bland — perhaps consistent with the content. "I realize this review has been critical of the lack of clinical usefulness of this book, but I cannot say that no one should read this work. It will not change the way medicine is practiced, but for those interested in the roots of the science that leads to clinical changes,this book may be of interest.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780127346106
  • Publisher: Elsevier Science
  • Publication date: 7/21/1998
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 263
  • Product dimensions: 6.27 (w) x 9.31 (h) x 0.88 (d)

Meet the Author

Eugenia Wang is Director of The Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research in Montreal, Canada. With a Ph.D. from Case Western Reserve University, Dr. Wang holds several current appointments including Associate Director, Division of Geriatric Medicine and Aging, Department of Medicine at McGill University, is a member of the National Advisory Council, National Institute of Aging, National Institutes of Health, and is Past Chairperson of the Biological Science Section of the Canadian Association on Gerontology.
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Table of Contents

M.S. Albert, Normal and Abnormal Memory: Aging and Alzheimer's Disease.
S.J. Lupien and M.J. Meaney, Stress, Glucocorticoids, and Hippocampal Aging in Rat and Human.
C.A. Barnes, Spatial Cognition and Functional Alterations of Aged Rat Hippocampus.
A.J. Silva, K.P. Giese, and P.W. Frankland, Identification of Molecular and Cellular Mechanisms of Learning and Memory: The Impact of Gene Targeting.
B.T. Hyman and T. Gomez-Isla, Normal Aging and Alzheimer's Disease.
J.-P. Julien, Transgenic Mouse Models with Neurofilament-Induced Pathologies.
P.C. Wong, D.R. Borchelt, M.K. Lee, G. Thinakaran, S.S. Sisodia, and D.L. Price, Transgenic Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease.
G.M. Martin, Toward a Genetic Analysis of Unusually Successful Neural Aging.
R.E. Tanzi, The Role of the Presenilins in Alzheimer's Disease.
J.Q. Trojanowski, J.E. Galvin, M.L. Schmidt, P.-H. Tu, T. Iwatsubo, and V.M.-Y. Lee, Mechanisms of Neuron Death in Neurodegenerative Diseases of the Elderly: Role of the Lewy Body.
S.-H. Yen, P. Nacharaju, L.-W. Ko, A. Kenessey, and W.-K. Liu, Microtubule-Associated Protein Tau: Biochemical Modifications, Degradation and Alzheimer's Disease.
K.S. Kosik, C. Ho, U. Liyange, C. Lemere, M. Medina, and J. Zhou, A Novel Gene in the Armadillo Family Interacts with Presenilin 1.
R. Quirion, D. Auld, U. Beffert, J. Poirier, and S. Kar, Putative Links Between Some of the Key Pathological Features of the Alzheimer's Brain.
A. LeBlanc, Unraveling the Controversy of Human Prion Protein Diseases.
E. Wang, Translational Control, Apoptosis, and the Aging Brain.
H.M. Schipper, Astrocyte Senescence and the Pathogenesis of Parkinson's Disease.
Index.
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