Handbook of the Biology of Aging / Edition 7

Handbook of the Biology of Aging / Edition 7

by Edward J. Masoro, Steven N. Austad
     
 

View All Available Formats & Editions

ISBN-10: 012378638X

ISBN-13: 9780123786388

Pub. Date: 12/02/2010

Publisher: Elsevier Science

Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences.
The book is organized into two parts. Part 1 covers basic aging processes. It

Overview

Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences.
The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature.
The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians.

  • Contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans
  • Covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc.
  • Edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology

Product Details

ISBN-13:
9780123786388
Publisher:
Elsevier Science
Publication date:
12/02/2010
Series:
Handbooks of Aging Series
Edition description:
New Edition
Pages:
520
Product dimensions:
6.90(w) x 9.90(h) x 1.30(d)

Related Subjects

Table of Contents

Contributors vii

Foreword ix

Preface xi

About the Editors xiii

Part 1 Basic Aging Processes

1 The Genetic Network of Life-Span Extension by Dietary Restriction Eric Greer Anne Brunet 3

2 Role of the Somatotropic Axis in Mammalian Aging Holly M. Brown-Borg 25

3 Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process Casey L. Quinlan Jason R. Treberg Martin D. Brand 47

4 Aging and Apoptosis in Muscle Stephen E. Alway Michael R. Morissette Parco M. Siu 63

5 Aging and Adipose Tissue Roberta Florido Tamara Tchkonia James L. Kirkland 119

6 Aging of Stem Cells: Intrinsic Changes and Environmental Influences Ling Liu Thomas A. Rando 141

7 Leukocyte Telomere Dynamics, Human Aging, and Life Span Abraham Aviv 163

8 An Objective Appraisal of the Free Radical Theory of Aging Michael Lustgarten Florian L. Muller Holly Van Remmen 177

9 TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species Pankaj Kapahi Lutz Kockel 203

10 Comparative Genetics of Aging George L. Sutphin Matt Kaeberlein 215

11 Sirtuins in Aging and Age-Related Diseases Marcia C. Haigis David A. Sinclair 243

12 Inflammation in Aging Processes: An Integrative and Ecological Perspective Caleb E. Finch 275

13 Protein Homeostasis and Aging Susmita Kaushik Ana Maria Cuervo 297

Part 2 Medical Physiology of Aging

14 Terminal Weight Loss, Frailty, and Mortality Edward J. Masoro 321

15 Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction Jonathan E. Sherin George Bartzokis 333

16 Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions Farzaneh A. Sorond Lewis A. Lipsitz 347

17 Aging and Insulin Secretion Jeffrey B. Halter 373

18 Cardiovascular Effects of Aging in Primates-Gender Differences Hongyu Qiu Christophe Depre Dorothy E. Vatner Stephen F. Vatner 385

19 Cerebral Vascular Dysfunction with Aging Frank M. Faraci 405

20 Pulmonary Function in Aging Humans Nigel A.S. Taylor 421

21 Calorie Restriction in Nonhuman and Human Primates Luigi Fontana Ricki J. Colman John O. Holloszy Richard Weindruch 447

22 Age-Related Changes in Thermoreception and Thermoregulation Eus J.W. Van Someren 463

23 Sex Differences in Longevity and Aging Steven N. Austad 479

Author Index 497

Subject Index 565

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >