Handbook of the Biology of Aging / Edition 6

Handbook of the Biology of Aging / Edition 6

by Edward J. Masoro
     
 

ISBN-10: 0120883872

ISBN-13: 9780120883875

Pub. Date: 12/01/2005

Publisher: Elsevier Science

The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses.

The Sixth Edition is 20% larger than the Fifth Edition, with 21

Overview

The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses.

The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship.

The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging.

The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.

Product Details

ISBN-13:
9780120883875
Publisher:
Elsevier Science
Publication date:
12/01/2005
Series:
Handbooks of Aging Series
Edition description:
Older Edition
Pages:
682
Product dimensions:
1.50(w) x 10.00(h) x 7.00(d)

Table of Contents

Contributors vii

Foreword ix

Preface xi

About the Editors xiii

Part 1 Basic Aging Processes

1 The Genetic Network of Life-Span Extension by Dietary Restriction Eric Greer Anne Brunet 3

2 Role of the Somatotropic Axis in Mammalian Aging Holly M. Brown-Borg 25

3 Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process Casey L. Quinlan Jason R. Treberg Martin D. Brand 47

4 Aging and Apoptosis in Muscle Stephen E. Alway Michael R. Morissette Parco M. Siu 63

5 Aging and Adipose Tissue Roberta Florido Tamara Tchkonia James L. Kirkland 119

6 Aging of Stem Cells: Intrinsic Changes and Environmental Influences Ling Liu Thomas A. Rando 141

7 Leukocyte Telomere Dynamics, Human Aging, and Life Span Abraham Aviv 163

8 An Objective Appraisal of the Free Radical Theory of Aging Michael Lustgarten Florian L. Muller Holly Van Remmen 177

9 TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species Pankaj Kapahi Lutz Kockel 203

10 Comparative Genetics of Aging George L. Sutphin Matt Kaeberlein 215

11 Sirtuins in Aging and Age-Related Diseases Marcia C. Haigis David A. Sinclair 243

12 Inflammation in Aging Processes: An Integrative and Ecological Perspective Caleb E. Finch 275

13 Protein Homeostasis and Aging Susmita Kaushik Ana Maria Cuervo 297

Part 2 Medical Physiology of Aging

14 Terminal Weight Loss, Frailty, and Mortality Edward J. Masoro 321

15 Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction Jonathan E. Sherin George Bartzokis 333

16 Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions Farzaneh A. Sorond Lewis A. Lipsitz 347

17 Aging and Insulin Secretion Jeffrey B. Halter 373

18 Cardiovascular Effects of Aging in Primates-Gender Differences Hongyu Qiu Christophe Depre Dorothy E. Vatner Stephen F. Vatner 385

19 Cerebral Vascular Dysfunction with Aging Frank M. Faraci 405

20 Pulmonary Function in Aging Humans Nigel A.S. Taylor 421

21 Calorie Restriction in Nonhuman and Human Primates Luigi Fontana Ricki J. Colman John O. Holloszy Richard Weindruch 447

22 Age-Related Changes in Thermoreception and Thermoregulation Eus J.W. Van Someren 463

23 Sex Differences in Longevity and Aging Steven N. Austad 479

Author Index 497

Subject Index 565

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