Handbook of the Biology of Aging / Edition 5

Handbook of the Biology of Aging / Edition 5

by Edward J. Masoro, Edward J. Masoro, Steven N. Austad
     
 

ISBN-10: 0124782604

ISBN-13: 9780124782600

Pub. Date: 05/04/2001

Publisher: Elsevier Science & Technology Books

The Fifth Edition of the Handbook of the Biology of Aging continues the tradition of providing a comprehensive overview of some of the most important topics in biomedical gerontology. Beginning with an introduction to concepts and theories of aging, the book is then divided into three main sections covering cellular processes in organismic aging,

Overview

The Fifth Edition of the Handbook of the Biology of Aging continues the tradition of providing a comprehensive overview of some of the most important topics in biomedical gerontology. Beginning with an introduction to concepts and theories of aging, the book is then divided into three main sections covering cellular processes in organismic aging, systemic factors in organismic aging, and models of retarded aging. The book closes with a look at the future of biomedical research as it relates to aging, health, and longevity.
The Handbook will be of interest to biologists involved in aging research, gerontologists, medical researchers, psychologists, sociologists, and practitioners dealing with an aging population.
The Fifth Edition:

* opens with a broad introduction to theories and concepts of aging

* provides new insight into the cellular and systemic aspects of aging

* features new chapters on cellular proliferation, apoptosis, and environment-gene interactions

Product Details

ISBN-13:
9780124782600
Publisher:
Elsevier Science & Technology Books
Publication date:
05/04/2001
Series:
Handbooks of Aging
Edition description:
REV
Pages:
534
Product dimensions:
6.90(w) x 9.98(h) x 1.07(d)

Table of Contents

Contributors vii

Foreword ix

Preface xi

About the Editors xiii

Part 1 Basic Aging Processes

1 The Genetic Network of Life-Span Extension by Dietary Restriction Eric Greer Anne Brunet 3

2 Role of the Somatotropic Axis in Mammalian Aging Holly M. Brown-Borg 25

3 Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process Casey L. Quinlan Jason R. Treberg Martin D. Brand 47

4 Aging and Apoptosis in Muscle Stephen E. Alway Michael R. Morissette Parco M. Siu 63

5 Aging and Adipose Tissue Roberta Florido Tamara Tchkonia James L. Kirkland 119

6 Aging of Stem Cells: Intrinsic Changes and Environmental Influences Ling Liu Thomas A. Rando 141

7 Leukocyte Telomere Dynamics, Human Aging, and Life Span Abraham Aviv 163

8 An Objective Appraisal of the Free Radical Theory of Aging Michael Lustgarten Florian L. Muller Holly Van Remmen 177

9 TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species Pankaj Kapahi Lutz Kockel 203

10 Comparative Genetics of Aging George L. Sutphin Matt Kaeberlein 215

11 Sirtuins in Aging and Age-Related Diseases Marcia C. Haigis David A. Sinclair 243

12 Inflammation in Aging Processes: An Integrative and Ecological Perspective Caleb E. Finch 275

13 Protein Homeostasis and Aging Susmita Kaushik Ana Maria Cuervo 297

Part 2 Medical Physiology of Aging

14 Terminal Weight Loss, Frailty, and Mortality Edward J. Masoro 321

15 Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction Jonathan E. Sherin George Bartzokis 333

16 Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions Farzaneh A. Sorond Lewis A. Lipsitz 347

17 Aging and Insulin Secretion Jeffrey B. Halter 373

18 Cardiovascular Effects of Aging in Primates-Gender Differences Hongyu Qiu Christophe Depre Dorothy E. Vatner Stephen F. Vatner 385

19 Cerebral Vascular Dysfunction with Aging Frank M. Faraci 405

20 Pulmonary Function in Aging Humans Nigel A.S. Taylor 421

21 Calorie Restriction in Nonhuman and Human Primates Luigi Fontana Ricki J. Colman John O. Holloszy Richard Weindruch 447

22 Age-Related Changes in Thermoreception and Thermoregulation Eus J.W. Van Someren 463

23 Sex Differences in Longevity and Aging Steven N. Austad 479

Author Index 497

Subject Index 565

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