- Shopping Bag ( 0 items )
Doody's Review ServiceReviewer: Carlos E Figueroa Castro, MD (Medical College of Wisconsin)
Description: This second volume in the Handbook of Tuberculosis series covers the immunology and cell biology of Mycobacterium tuberculosis, the etiologic agent of tuberculosis.
Purpose: The main purpose of the series is to summarize the existing knowledge on tuberculosis and, as expected, this book successfully focuses on the immunology and cell biology aspects. The book and the series in general are an important tool to understand the relevance of the global emergency that tuberculosis represents.
Audience: The book is intended for a wide audience. It will be a source of up-to-date information for researchers in immunology, cellular, and molecular biology, biochemists, and infectious disease specialists. The authors, all experts in their respective fields, include investigators from Europe, the United States, and Australia.
Features: Multiple aspects of the cellular and humoral immune response against M. tuberculosis are covered. An interesting discussion covers the role of dendritic cells and the recently described Th17 T-cells and other unconventional cells in the pathogenesis of tuberculosis. A chapter on the host immune response on HIV/TB co-infection will be obligatory reading for HIV medicine practitioners, although more discussion of immune reconstitution inflammatory syndrome would have been a great addition. Some chapters would benefit from illustrations, especially with the increasing number of cytokines and signal transduction pathways involved. Some redundancy is inevitable, but it is related to the complexity of the issues.
Assessment: As with the other volumes in this series, this will become a reference for anyone interested in the immunology and cell biology of M. tuberculosis, regardless of their experience with these subjects.