Handbook of Tuberculosis: Immunology and Cell Biology / Edition 1

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This second of the three-volume tuberculosis book series provides a comprehensive overview of immunological and cell biological aspects of tuberculosis. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of TB.

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Editorial Reviews

Doody's Review Service
Reviewer: Carlos E Figueroa Castro, MD (Medical College of Wisconsin)
Description: This second volume in the Handbook of Tuberculosis series covers the immunology and cell biology of Mycobacterium tuberculosis, the etiologic agent of tuberculosis.
Purpose: The main purpose of the series is to summarize the existing knowledge on tuberculosis and, as expected, this book successfully focuses on the immunology and cell biology aspects. The book and the series in general are an important tool to understand the relevance of the global emergency that tuberculosis represents.
Audience: The book is intended for a wide audience. It will be a source of up-to-date information for researchers in immunology, cellular, and molecular biology, biochemists, and infectious disease specialists. The authors, all experts in their respective fields, include investigators from Europe, the United States, and Australia.
Features: Multiple aspects of the cellular and humoral immune response against M. tuberculosis are covered. An interesting discussion covers the role of dendritic cells and the recently described Th17 T-cells and other unconventional cells in the pathogenesis of tuberculosis. A chapter on the host immune response on HIV/TB co-infection will be obligatory reading for HIV medicine practitioners, although more discussion of immune reconstitution inflammatory syndrome would have been a great addition. Some chapters would benefit from illustrations, especially with the increasing number of cytokines and signal transduction pathways involved. Some redundancy is inevitable, but it is related to the complexity of the issues.
Assessment: As with the other volumes in this series, this will become a reference for anyone interested in the immunology and cell biology of M. tuberculosis, regardless of their experience with these subjects.
From the Publisher
As with the other volumes in this series, this will become a reference for anyone interested in the immunology and cell biology of M. tuberculosis, regardless of their experience with these subjects. (Doody's, July 2008)
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Product Details

  • ISBN-13: 9783527318872
  • Publisher: Wiley
  • Publication date: 3/21/2008
  • Edition number: 1
  • Pages: 460
  • Product dimensions: 6.97 (w) x 9.69 (h) x 1.06 (d)

Meet the Author

Prof. Dr. Stefan H.E. Kaufmann is Founding Director of the Max Planck Institute for Infection Biology, Berlin. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e.g. current President of the European Federation of Immunological Societies, and Chair of the Immunology division of the American Society of Microbiology. He has won numerous prestigious awards including the Scientific Prize of Smith Kline Beecham and the Pettenkofer Prize.

Warwick Britton is Professor of Medicine at the University of Sydney, Australia. He serves as Chairman of the State Committee for the Australian Society of Clinical Immunology and Allergy.

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Table of Contents

Immunity to M. tuberculosis and BCG: Introduction
Recognition Receptors and Phagocytosis for M. tuberculosis
Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis
Dendritic Cells and Antigen Presentation
Killing Mechanisms of the Host Against M. tuberculosis
Manipulation of the Macrophage Response
Conventional T Cells and their Antigenic Repertoire
Unconventional T Cells
Cytokines in Tuberculosis
Antibodies in Tuberculosis
Maintenance of Latent Infection with Correlates of Protective Immunity
Genetics of Resistance (mouse and man)
HIV/TB Interactions
Novel Vaccination Strategies Against Tuberculosis
Experimental Animal Models of Tuberculosis

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