Handbook on Injectable Drugs / Edition 16

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Nearly every field has its touchstone.

In the ever-changing, data-intense, split-second decision world of parenteral drugs, that touchstone, that premier resource, is the Handbook on Injectable Drugs, 16th Edition.

It is the leading injectable drug guide, trusted, turned to and touted the world over for its intuitive, easy to use layout, and its accessible organization and presentation of data.

The 16th edition of the Handbook on Injectable Drugs brings together a wealth of information on 349 parenteral drugs commercially available in the United States and in other countries.

Compatibility, stability, storage and preparation data for each have been painstakingly referenced and clearly presented. There are 64 new references, for a total of 2,788.

Once again, the book is edited by Lawrence A. Trissel, FASHP, as has been the case for over 30 years of continuous publication. And once again, Mr. Trissel and the Handbook on Injectable Drugs set the standard for comprehensiveness, speed, and trustworthiness.

The Handbook is also available in a CD-ROM format, which can be bought as a package with the print version. The CD allows you to screen up to five drugs/solutions for compatibility simultaneously, access original research through PubMed, and search concise table summaries of compatibility results.


The book contains no figures.

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Editorial Reviews

From The Critics
Reviewer: Christopher Widdick, PharmD Student(Temple University School of Pharmacy)
Description: This is the sixteenth edition of a guide to the stability and compatibility of intravenous medications that is updated every two to three years.
Purpose: It is intended as a reference for the safe administration of parenteral medications to patients, covering stability, osmolality, pH, and compatibility of parenteral drugs. Lawrence Trissel does an astonishing job of gathering a colossal amount of drug data and organizing it for quick retrieval in this one-stop resource.
Audience: This book is specifically targeted at healthcare professionals who practice in either inpatient or ambulatory settings where parenteral drugs will be administered frequently. It is published by the American Society of Health-System Pharmacists, as credible a source as there is.
Features: Based on the generic name, each parenteral drug is listed in alphabetical order by sections. The brand name, if the drug is still available as such, is listed under the primary heading "Products" in each monograph as well as the index. Each drug section is broken up into four sets of tables. Table 1 covers "Solution Compatibility," such as the referenced drug placed into sodium chloride 0.9% or dextrose 5%. Table 2 describes the "Additive Compatibility" and evaluates the referenced drug in addition to a second independent drug (example: acyclovir and hydromorphone in one IV bag). Table 3, "Drugs in Syringe Compatibility," discusses whether two drugs drawn up into the same syringe are physically stable. Finally, Table 4, "Y-Site Injection Compatibility," states whether two drugs can be administered safely without precipitation into an intravenous access port. Each of the tables describing compatibility lists the drug, manufacturer, reference source number, and concentration, with additional remarks concerning time and temperature stability. This user-friendly format provides a wealth of data in a layout that makes it easy to retrieve.
Assessment: Any practicing pharmacists who frequently deal with injectable drugs would be hard pressed to find this amount of information on drug stability/compatibility in one easily retrievable resource without this book. It is the gold standard for this type of information. As healthcare practice changes all the time with the discovery of new drugs and the emergence of new data on existing drugs, references like this must be kept up to date, which justifies this new edition.
Cheryl Lynn Nunn-Thompson
This book contains summaries of information (in both narrative and tabular formats) derived from published literature on the clinical pharmaceutics of parenteral medications. This edition replaces the 10th edition published in 1998. The purpose is to facilitate the use of clinical pharmaceutics research by knowledgeable healthcare professionals for the benefit of patients. This book is an important reference tool for pharmacists involved in the preparation and administration of parenteral medications. This well-respected and unique text has been meeting this objective since the publication of the first edition over 23 years ago. The handbook is intended to supplement the practice of pharmacists, pharmacy students, and other healthcare professionals who can correctly interpret and apply the clinical pharmaceutics information contained in this text to specific patient concerns, so as to assure the safe and effective use of parenteral medications. This text continues to be authored by a highly respected and well-known expert in the field of clinical pharmaceutics. It contains a collection of up-to-date monographs on 300 drugs commercially available in the U.S., plus monographs on 25 drugs available outside the U.S., but for which there exists a substantial quantity of clinical pharmaceutics information. Each monograph is organized in a concise, standardized format; information such as product description (including pH, osmotic values, and dilution information), administration, and stability are provided in narrative format. Drug compatibility information is provided in a tabular format; four tables summarize information regarding solution, additive, syringe and Y-site compatibility. Thetext is well referenced, and truly represents a summation of the currently published literature in clinical pharmaceutics. A unique feature is a brief instructional chapter that reviews the important principles of drug stability and compatibility as it relates to drug delivery. This provides essential and concisely summarized information regarding the compatibility and stability (physical and chemical) of approximately 300 parenteral medications. In comparison to Catania's King Guide to Parenteral Admixtures 2000 - 4 Volume Set (King Guide Publications, Inc., 2000), this handbook offers 25 percent fewer drug monographs and is updated less frequently; yet it provides more complete and comprehensive information on the drugs presented. This is an important core text for any practicing pharmacist involved in the safe and effective administration of parenteral medications.
Linda Grider
This vital reference text on parenteral medications is now available in its expanded eighth edition. This book provides essential information on the compatibility/stability issues encountered in parenteral drug therapy. It additionally provides product information, routes, and rates of administration, and appropriate dosages. Pharmacists in patient care settings will utilize this indispensable text on a daily basis. It also provides an invaluable reference source for pharmacy students and other health care professionals. This latest edition provides almost 200 pages of additional integral information. Contained in the text are new monographs, a section on investigational drugs, an expanded section on parenterals available outside of the United States, and an update on all previous parenteral information and references. The presentation format is as organized and exacting as it has been in previous editions. Given the rapid influx of new agents and the availability of added compatibility/stability data, this new edition is a very welcome sight. This text represents a major reference source in the area of parenteral medications. It is imperative that practitioners have access to this type of information for the provision of quality pharmaceutical care. This book provides current information to address any number of patient care issues that may arise due to parenteral drug therapy concerns. The quantity and quality of information contained in this one text provides a very strong foundation for a reference source.
Laurence A. Goldberg
Handbook on Injectable Drugs 17th Edition 
By Lawrence A. Trissel

By Laurence A. Goldberg
Final edition on injectables from Trissel does not disappointThis 17th edition brings together information on 332 parenteral drugs available commercially in the US and other countries. The sources of this information are accumulated from 2,830 references, including 42 new to this edition. As in each of the previous editions, the monographs have been completely updated. In addition, some monographs have been reorganised and redundant material pruned to make the book easier to use, especially in the electronic form.
The book is designed for ease of use in clinical situations. Monographs are listed alphabetically by non-proprietary name. The names of the drugs follow the style of the USP Dictionary of Drug Names. American Hospital Formulary Service drug information reference codes are conveniently located at the top of each monograph to refer the reader to more detailed information.  
The aim of this book has remained unchanged over the years: to organise and summarise, in a concise and standardised format, the results of the primary research into drug stability and compatibility and to facilitate the use of parenteral drugs in clinical practice for the benefit of patients. This edition, like the previous 16, achieves this aim. It is an essential reference source for those professionals involved in the preparation or clinical use of injectable drugs. The author has spent tens of thousands of hours preparing the 17 editions of this book. The sacrifice of his time was made in the knowledge that his efforts were providing useful and valuable information in patient care. He has now decided that this edition will be his last and his cherished work will be passed on to others.
Laurence A. Goldberg is a pharmaceutical consultant from Bury, Lancashire

5 Stars! from Doody
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Product Details

  • ISBN-13: 9781585282487
  • Publisher: American Society of Health-System Pharmacists
  • Publication date: 10/1/2010
  • Series: Handbook of Injectable Drugs Series
  • Edition number: 16
  • Pages: 1661
  • Product dimensions: 8.70 (w) x 11.10 (h) x 2.80 (d)

Meet the Author

Lawrence A. Trissel, B.S. Pharm., FASHP

Lawrence Trissel has served as Director of Clinical Pharmaceutics Research, Division of Pharmacy at the University of Texas, M.D. Anderson Cancer Center, where he managed the development and compounding of specialty investigational drug products. Trissel has also been the Senior Research Products Manager, Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment at the National Cancer Institute, within the National Institutes of Health.

Mr. Trissel is now an independent author and research consultant. Mr. Trissel is best known as the author of Handbook on Injectable Drugs, a core pharmacy reference work found in nearly every hospital and home care pharmacy in the United States and throughout the world. In addition, he has authored several other reference books currently in print Mr. Trissel is the author or co-author of more than 195 original articles, book chapters, and editorials, including 160 original research contributions.

Mr. Trissel is a member of numerous professional organizations, including the American Society of Health-System Pharmacists and the American Pharmacy Association. He has served as a member of two United States Pharmacopeia Expert Committees on Pharmacy Compounding for both nonsterile and sterile preparations. Mr. Trissel has been the recipient of several awards and honors throughout his career, including the American Pharmacy Association Distinguished Achievement Award in 2002 and the Award for Sustained Contributions to the Published Literature from the American Society of Health-System Pharmacists in 1996. He was recently selected as a Distinguished Alumnus of Butler University in its inaugural class.


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Table of Contents


Acknowledgments............................................. VII

Preface ............................................................. IX

How to Use the Handbook................................... XI

Commercial Drug Monographs.............................. 1

Appendix I: Parenteral Nutrition Formula............... 1565

References......................................................... 1585

Index.............................................................. 1655

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