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Doody's Review ServiceReviewer: Beth A Baker, MD, MPH (HealthPartners)
Description: This handbook provides a useful and comprehensive review of metal toxicity.
Purpose: The purpose is to comprehensively cover the effects of metals on biological systems.
Audience: This will be useful for physician toxicologists, nonphysician toxicologists, and anyone else interested in the health effects of metals. The authors, who include many international experts, state it will be a standard reference for physicians, toxicologists, and engineers.
Features: The initial chapters include in-depth reviews of metals chemistry and analytical detection, routes or exposure and metabolism, and methods for biological monitoring and biomarkers. Mechanisms of toxicity are discussed, including interference with the function of essential metals by toxic metals, metal binding molecules, and mutagenic and geotaxis effects. Dose response and dose effect relationships are extensively discussed. Risk assessment for metal toxicity is also covered, including assessment of exposures to a mixture of metals. The effect of essential metals deficiency and toxicity is covered extensively. Carcinogenicity, immunotoxicology, and reproductive effect of metals are also discussed. A very interesting and detailed discussion of the ecotoxicology of metals includes the sources, transport, and effect of metals on the ecosystem. The last half of the handbook contains chapters on specific metals such as lead or arsenic. These chapters include specific metal physical and chemical properties, uses, environmental levels and exposure, kinetics, biological monitoring, animal and human effects, dose response relationship, and appropriate treatment.
Assessment: This is an excellent resource for toxicologists on the myriad effects of metals on animals, humans and the environment. This third edition does a wonderful job of updating the previous edition.