Handbook on the Toxicology of Metals / Edition 3

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Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds.

• Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter
• New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

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Editorial Reviews

From the Publisher
"It will find its way to many bookshelves at hospitals, industrial and governmental libraries and several research institutes in every part of the world."
Doody's Review Service
Reviewer: Beth A Baker, MD, MPH (HealthPartners)
Description: This handbook provides a useful and comprehensive review of metal toxicity.
Purpose: The purpose is to comprehensively cover the effects of metals on biological systems.
Audience: This will be useful for physician toxicologists, nonphysician toxicologists, and anyone else interested in the health effects of metals. The authors, who include many international experts, state it will be a standard reference for physicians, toxicologists, and engineers.
Features: The initial chapters include in-depth reviews of metals chemistry and analytical detection, routes or exposure and metabolism, and methods for biological monitoring and biomarkers. Mechanisms of toxicity are discussed, including interference with the function of essential metals by toxic metals, metal binding molecules, and mutagenic and geotaxis effects. Dose response and dose effect relationships are extensively discussed. Risk assessment for metal toxicity is also covered, including assessment of exposures to a mixture of metals. The effect of essential metals deficiency and toxicity is covered extensively. Carcinogenicity, immunotoxicology, and reproductive effect of metals are also discussed. A very interesting and detailed discussion of the ecotoxicology of metals includes the sources, transport, and effect of metals on the ecosystem. The last half of the handbook contains chapters on specific metals such as lead or arsenic. These chapters include specific metal physical and chemical properties, uses, environmental levels and exposure, kinetics, biological monitoring, animal and human effects, dose response relationship, and appropriate treatment.
Assessment: This is an excellent resource for toxicologists on the myriad effects of metals on animals, humans and the environment. This third edition does a wonderful job of updating the previous edition.
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Product Details

  • ISBN-13: 9780123694133
  • Publisher: Elsevier Science
  • Publication date: 5/1/2007
  • Edition number: 3
  • Pages: 1024
  • Product dimensions: 2.06 (w) x 8.50 (h) x 11.00 (d)

Meet the Author

Bruce A. Fowler, PhD, A.T.S, Senior Fellow of ICF International, Fairfax, VA
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Table of Contents

Introduction – General Considerations and International Perspectives
General Chemistry, Sampling, Analytical Methods and Speciation
Routes of Exposure, Dose, and Metabolism of Metals
Biological Monitoring and Biomarkers
Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity
General Considerations of Dose-Effect and Dose-Response Relationships
Interactions in Metal Toxicology
Epidemiological Methods for Assessing Dose-Response and Dose-Effect Relationships
Essential Metals: Assessing Risks from Deficiency and Toxicity
Carcinogenicity of Metal Compounds
Immunotoxicology of Metals
Reproductive and Developmental Toxicity of Metals
Ecotoxicology of Metals - Sources, Transport, and Effects in the Ecosystem
Risk Assessment
Diagnosis and Treatment of Metal Poisoning - General Aspects
Principles for Prevention of the Toxic Effects of Metals
Gallium and Semiconductor Compounds

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