Handbook on the Toxicology of Metals / Edition 3

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Overview

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more.

Volume I covers “General Considerations” and Volume II is devoted to “Specific Metals.” A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

  • Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems
  • Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health
  • Covers the toxicology of metallic nanomaterials in a new comprehensive chapter
  • Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste”
  • Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium
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Editorial Reviews

Doody's Review Service
Reviewer: Beth A Baker, MD, MPH (HealthPartners)
Description: This handbook provides a useful and comprehensive review of metal toxicity.
Purpose: The purpose is to comprehensively cover the effects of metals on biological systems.
Audience: This will be useful for physician toxicologists, nonphysician toxicologists, and anyone else interested in the health effects of metals. The authors, who include many international experts, state it will be a standard reference for physicians, toxicologists, and engineers.
Features: The initial chapters include in-depth reviews of metals chemistry and analytical detection, routes or exposure and metabolism, and methods for biological monitoring and biomarkers. Mechanisms of toxicity are discussed, including interference with the function of essential metals by toxic metals, metal binding molecules, and mutagenic and geotaxis effects. Dose response and dose effect relationships are extensively discussed. Risk assessment for metal toxicity is also covered, including assessment of exposures to a mixture of metals. The effect of essential metals deficiency and toxicity is covered extensively. Carcinogenicity, immunotoxicology, and reproductive effect of metals are also discussed. A very interesting and detailed discussion of the ecotoxicology of metals includes the sources, transport, and effect of metals on the ecosystem. The last half of the handbook contains chapters on specific metals such as lead or arsenic. These chapters include specific metal physical and chemical properties, uses, environmental levels and exposure, kinetics, biological monitoring, animal and human effects, dose response relationship, and appropriate treatment.
Assessment: This is an excellent resource for toxicologists on the myriad effects of metals on animals, humans and the environment. This third edition does a wonderful job of updating the previous edition.
Doody's Review Service
Reviewer: Beth A Baker, MD, MPH (HealthPartners)
Description: This handbook provides a useful and comprehensive review of metal toxicity.
Purpose: The purpose is to comprehensively cover the effects of metals on biological systems.
Audience: This will be useful for physician toxicologists, nonphysician toxicologists, and anyone else interested in the health effects of metals. The authors, who include many international experts, state it will be a standard reference for physicians, toxicologists, and engineers.
Features: The initial chapters include in-depth reviews of metals chemistry and analytical detection, routes or exposure and metabolism, and methods for biological monitoring and biomarkers. Mechanisms of toxicity are discussed, including interference with the function of essential metals by toxic metals, metal binding molecules, and mutagenic and geotaxis effects. Dose response and dose effect relationships are extensively discussed. Risk assessment for metal toxicity is also covered, including assessment of exposures to a mixture of metals. The effect of essential metals deficiency and toxicity is covered extensively. Carcinogenicity, immunotoxicology, and reproductive effect of metals are also discussed. A very interesting and detailed discussion of the ecotoxicology of metals includes the sources, transport, and effect of metals on the ecosystem. The last half of the handbook contains chapters on specific metals such as lead or arsenic. These chapters include specific metal physical and chemical properties, uses, environmental levels and exposure, kinetics, biological monitoring, animal and human effects, dose response relationship, and appropriate treatment.
Assessment: This is an excellent resource for toxicologists on the myriad effects of metals on animals, humans and the environment. This third edition does a wonderful job of updating the previous edition.
From the Publisher
"It will find its way to many bookshelves at hospitals, industrial and governmental libraries and several research institutes in every part of the world."
-SCIENCE OF THE TOTAL ENVIRONMENT
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Product Details

  • ISBN-13: 9780123694133
  • Publisher: Elsevier Science
  • Publication date: 5/1/2007
  • Edition number: 3
  • Pages: 1024
  • Product dimensions: 2.06 (w) x 8.50 (h) x 11.00 (d)

Meet the Author

Bruce A. Fowler, PhD, A.T.S, Senior Fellow of ICF International, Fairfax, VA
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Table of Contents

VOLUME I General Considerations VOLUME II Specific Metals

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