Hannah's Heirs: The Quest for the Genetic Origins of Alzheimer's Disease / Edition 1

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Overview

In the first edition of Hannah's Heirs, neurologist Dr. Daniel A. Pollen told the compelling story of Hannah's family and their monumental contributions to the fight against Alzheimer's. Now, this internationally acclaimed story resumes in this updated paperback edition with the discovery in June, 1995 of Hannah's gene -- now known to account for the majority of mutations causing early onset familial Alzheimer's disease -- and the equally important identification of the major genetic risk factor rendering increased susceptibility to the more frequently occurring late-onset Alzheimer's. With these recent discoveries, medical science is now poised to reach for an understanding of the causes of the various forms of Alzheimer's disease which, in turn, will inevitably lead to rational attempts to treat and prevent Alzheimer's. This fascinating medical detective story of modern science's promising assault on "the disease of the century" continues to unfold with suspense and to inform and inspire through the final word.

Written by a physician-scientist who has been a central figure in the study of familial Alzheimer's, this inspiring portrait tells of the efforts of a courageous family to confront and overcome Alzheimer's. An encouraging look at the advances in science that have created the basis for the eventual understanding and treatment of the disease.

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Product Details

  • ISBN-13: 9780195106527
  • Publisher: Oxford University Press, USA
  • Publication date: 7/28/1996
  • Edition description: ENL
  • Edition number: 1
  • Pages: 336
  • Product dimensions: 6.13 (w) x 9.19 (h) x 0.85 (d)

Meet the Author

About the Author: Daniel A. Pollen, M.D., is Professor of Neurology and Physiology at the University of Massachusetts Medical Center.

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Table of Contents

Prologue 3
Part I Founders
The Life and Death of Hannah 11
Gregor Mendel 17
Alois Alzheimer 21
Part II Into the Wilderness
The Descendants of Hannah and Shlomo 33
Mendel's Heirs 41
Alzheimer's Disease at Midcentury 55
Enter Genetics 59
New Seeds Are Sown 69
No Longer Alone 75
Twin Pillars of Hope 79
A Transmissible Virus? 87
Base Camp, Circa 1980 95
Part III The Ascent
The New Basis for Linkage Maps of the Human Genome 105
The Quest for the Huntington's Disease Gene 119
Charles 131
Peter St. George-Hyslop and the Link to Chromosome 21 135
A Gene for Amyloid 149
A Siege of the Soul 155
Elizabeth W. and the Second Family from Bobruisk 159
A Unity of Heart and Mind 163
Russia Once Again 171
The Twenty-one Pedigrees of Nina Ivanovna Voskresenskaya 175
How Many Genes? 181
The Third Dove Goes Forth 187
Part IV The Path Ahead
Lost Tribes 193
The First Abnormal Gene Is Found 205
New Sightings 219
Mutual Aid as a Factor in Evolution and in Genetic Research 227
Hannah's Heirs 237
Epilogue
Landfall 241
Hannah's Gene 259
Notes 269
References 287
Index 303
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