Hannah's Heirs: The Quest for the Genetic Origins of Alzheimer's Disease / Edition 1

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In Hannah's Heirs, Dr. Pollen himself tells the compelling story of Ha nnah's family and their monumental contributions to the fight against Alzheimer's. We are there in 1985 when Charles presents Pollen with th ree decades' worth of family medical records as well as data from stud ies that even Pollen and his associates did not then know existed. We see the selfless acts of Hannah's descendants in their struggle agains t Alzheimer's: great-grandson Jeff's conviction that after his death h is brain be used for all possible research; great-granddaughter Lucy's decision to overcome her dread of flying in order to reach the resear ch center for testing; and Charles's continued research in the face of a disease that might strike him at any moment.

Written by a physician-scientist who has been a central figure in the study of familial Alzheimer's, this inspiring portrait tells of the efforts of a courageous family to confront and overcome Alzheimer's. An encouraging look at the advances in science that have created the basis for the eventual understanding and treatment of the disease.

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Product Details

  • ISBN-13: 9780195106527
  • Publisher: Oxford University Press, USA
  • Publication date: 7/28/1996
  • Edition description: ENL
  • Edition number: 1
  • Pages: 336
  • Product dimensions: 6.13 (w) x 9.19 (h) x 0.85 (d)

Meet the Author

About the Author: Daniel A. Pollen, M.D., is Professor of Neurology and Physiology at the University of Massachusetts Medical Center.

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Table of Contents

Prologue 3
Part I Founders
The Life and Death of Hannah 11
Gregor Mendel 17
Alois Alzheimer 21
Part II Into the Wilderness
The Descendants of Hannah and Shlomo 33
Mendel's Heirs 41
Alzheimer's Disease at Midcentury 55
Enter Genetics 59
New Seeds Are Sown 69
No Longer Alone 75
Twin Pillars of Hope 79
A Transmissible Virus? 87
Base Camp, Circa 1980 95
Part III The Ascent
The New Basis for Linkage Maps of the Human Genome 105
The Quest for the Huntington's Disease Gene 119
Charles 131
Peter St. George-Hyslop and the Link to Chromosome 21 135
A Gene for Amyloid 149
A Siege of the Soul 155
Elizabeth W. and the Second Family from Bobruisk 159
A Unity of Heart and Mind 163
Russia Once Again 171
The Twenty-one Pedigrees of Nina Ivanovna Voskresenskaya 175
How Many Genes? 181
The Third Dove Goes Forth 187
Part IV The Path Ahead
Lost Tribes 193
The First Abnormal Gene Is Found 205
New Sightings 219
Mutual Aid as a Factor in Evolution and in Genetic Research 227
Hannah's Heirs 237
Landfall 241
Hannah's Gene 259
Notes 269
References 287
Index 303
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